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ARS Home » Northeast Area » Orient Point, New York » Plum Island Animal Disease Center » Foreign Animal Disease Research » Research » Research Project #431980

Research Project: Intervention Strategies to Support the Global Control and Eradication of Foot-and-Mouth Disease Virus (FMDV)

Location: Foreign Animal Disease Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80 - (Peer Reviewed Journal)
Chen, X., Gaglione, R., Leong, T., Bednor, L., De los Santos, T.B., Luk, E., Airola, M., Hollingsworth, N.M. 2018. Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1007832.

FMDV leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation - (Peer Reviewed Journal)
Visser, L.J., Medina, G.N., Rabouw, H.H., De Groot, R.J., Langereis, M.A., De los Santos, T.B., Van Kuppeveld, F.J. 2018. FMDV leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation. Journal of Virology. https://doi.org/10.1128/JVI.00922-18.

The different tactics of foot-and-mouth disease virus to evade innate immunity - (Peer Reviewed Journal)
Medina, G.N., Diaz San-Segundo, F., Stenfeldt, C., Arzt, J., De los Santos, T.B. 2018. The different tactics of foot-and-mouth disease virus to evade innate immunity. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2018.02644.

The development and validation of a novel nanobody-based competitive ELISA for the detection of foot and mouth disease 3ABC antibodies in cattle - (Peer Reviewed Journal)
Gelkop, S., Sobarzo, A., Brangel, P., Vincke, C., Romao, E., Fedida-Metula, S., Strom, N., Ataliba, I., Mwiin, F.N., Ochwo, S., Velazquez-Salinas, L., McKendry, R.A., Muyldermans, S., Lutwama, J.J., Rieder, A.E., Yavelsky, V., Lobel, L. 2018. The development and validation of a novel nanobody-based competitive ELISA for the detection of foot and mouth disease 3ABC antibodies in cattle. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2018.00250.

Transmission of foot-and-mouth disease from persistently infected carrier cattle to naive cattle via transfer of oropharyngeal fluid - (Peer Reviewed Journal)
Arzt, J., Belsham, G.J., Lohse, L., Botner, A., Stenfeldt, C. 2018. Transmission of foot-and-mouth disease from persistently infected carrier cattle to naive cattle via transfer of oropharyngeal fluid. mSphere. 3(5):e00365-18. https://doi.org/10.1128/mSphere.00365-18.

Lack of transmission of foot-and-mouth disease virus from persistently infected cattle to naïve cattle under field conditions in Vietnam - (Peer Reviewed Journal)
Bertram, M.R., Vu, L.T., Pauszek, S.J., Brito, B.P., Hartwig, E.J., Smoliga, G.R., Hoang, B.H., Phuong, N.T., Stenfeldt, C., Fish, I.H., Hung, V.V., Delgado, A., VanderWaal, K., Rodriguez, L.L., Long, N.T., Dung, D.H., Arzt, J. 2018. Lack of transmission of foot-and-mouth disease virus from persistently infected cattle to naïve cattle under field conditions in Vietnam. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2018.00174.

Foot-and-mouth disease infection dynamics in contact-exposed pigs are determined by the estimated exposure dose - (Peer Reviewed Journal)
Moreno-Torres, K.I., Brito, B.P., Branan, M.A., Rodriguez, L.L., Delgado, A.H., Stenfeldt, C., Arzt, J. 2018. Foot-and-mouth disease infection dynamics in contact-exposed pigs are determined by the estimated exposure dose. Frontiers in Veterinary Science. 5:167. https://doi.org/10.3389/fvets.2018.00167.

Characterization of naturally occurring, acute and persistent subclinical foot-and-mouth disease virus infection in vaccinated Asian buffalo in Pakistan - (Peer Reviewed Journal)

A traditional evolutionary history of foot-and-mouth disease viruses in Southeast Asia challenged by analyses of non-structural protein coding sequences - (Peer Reviewed Journal)
Brito, B.P., Pauszek, S.J., Hartwig, E.J., Smoliga, G.R., Vu, L.T., Vu, P.P., Stenfeldt, C., Rodriguez, L.L., King, D.P., Knowles, N.J., Bachanek-Bankowska, K., Long, N.T., Dung, D.H., Arzt, J. 2018. A traditional evolutionary history of foot-and-mouth disease viruses in Southeast Asia challenged by analyses of non-structural protein coding sequences. Scientific Reports. 8:6472. https://doi.org/10.1038/s41598-018-24870-6.

Effect of vaccination on cattle herds previously exposed to foot and mouth disease in Cameroon - (Peer Reviewed Journal)
Bertram, M.R., Delgado, A., Pauszek, S.J., Smoliga, G.R., Brito, B.P., Stenfeldt, C., Hartwig, E.J., Dickmu-Jumbo, S., Abdoulmoumini, M., Abona Olivia, A., Salhine, R., Rodriguez, L.L., Gerabed, R., Arzt, J. 2018. Effect of vaccination on cattle herds previously exposed to foot and mouth disease in Cameroon. Preventive Veterinary Medicine. 155:1-10. https://doi.org/10.1016/j.prevetmed.2018.04.003.

The need for improved vaccines against foot-and-mouth disease - (Peer Reviewed Journal)
De Los Santos, T.B., Diaz-San Segundo, F., Rodriguez, L.L. 2018. The need for improved vaccines against foot-and-mouth disease. Current Opinion in Virology. 29:16-25. https://doi.org/10.1016/j.coviro.2018.02.005.

The roles of picornavirus untranslated regions in infection and innate immunity - (Review Article)
Kloc, A., Rai, D.K., Rieder, A.E. 2018. The roles of picornavirus untranslated regions in infection and innate immunity. Frontiers in Microbiology. 20(9):485. https://doi.org/10.3389/fmicb.2018.00485.

An improved, rapid competitive ELISA using a novel conserved 3B epitope for the detection of serum antibodies to foot-and-mouth disease virus - (Peer Reviewed Journal)
Chung, C.J., Clavijo, A., Bounpheng, M., Uddowla, S., Sayed, A., Dancho, B., Olesen, I.C., Pacheco, J., Kamicker, B.J., Brake, D.A., Bandaranayaka-Mudiyanselage, C., Lee, S.S., Rai, D.K., Rieder, A.E. 2018. An improved, rapid competitive ELISA using a novel conserved 3B epitope for the detection of serum antibodies to foot-and-mouth disease virus. Journal of Veterinary Diagnostic Investigation. 30(5):699-707. https://doi.org/10.1177/1040638718779641.

A partial deletion within foot-and-mouth disease virus non-structural protein 3A causes clinical attenuation in cattle but does not prevent subclinical infection - (Peer Reviewed Journal)
Stenfeldt, C., Arzt, J., Pacheco, J., Gladue, D.P., Smoliga, G.R., Silva, E., Rodriguez, L.L., Borca, M.V. 2018. A partial deletion within foot-and-mouth disease virus non-structural protein 3A causes clinical attenuation in cattle but does not prevent subclinical infection. Virology. 516:115-126. https://doi.org/10.1016/j.virol.2018.01.008.

Clearance of a persistent Picornavirus infection is associated with enhanced pro-apoptotic and cellular immune responses - (Peer Reviewed Journal)
Stenfeldt, C., Eschbaumer, M., Smoliga, G.R., Rodriguez, L.L., Zhu, J.J., Arzt, J. 2017. Clearance of a persistent Picornavirus infection is associated with enhanced pro-apoptotic and cellular immune responses. Scientific Reports. 7:17800. https://doi.org/10.1038/s41598-017-18112-4.

Foot-and-mouth disease virus transmission dynamics and persistence in a herd of vaccinated dairy cattle in India - (Peer Reviewed Journal)
Hayder, S.S., VanderWaal, K., Ranjan, R., Biswal, J.K., Subramaniam, S., Mohapatra, J.K., Sharma, G.K., Rout, M., Dash, B., Das, B., Prusty, B., Sharma, A.K., Stenfeldt, C., Perez, A., Rodriguez, L.L., Arzt, J. 2017. Foot-and-mouth disease virus transmission dynamics and persistence in a herd of vaccinated dairy cattle in India. Transboundary and Emerging Diseases. 65(2):e404-e415. https://doi.org/10.1111/tbed.12774.

Genetic diversity and comparison of diagnostic tests for characterization of foot-and-mouth disease virus strains from Pakistan 2008-2012 - (Peer Reviewed Journal)
Ahmed, Z., Pauszek, S.J., Ludi, A., Larocco, M.A., Khan, E., Afzal, M., Arshed, M.J., Farooq, U., Arzt, J., Bertram, M., Brito, B., Naeem, K., Abubakar, M., Rodriguez, L.L. 2017. Genetic diversity and comparison of diagnostic tests for characterization of foot-and-mouth disease virus strains from Pakistan 2008-2012. Transboundary and Emerging Diseases. 65(2):534-546. https://doi.org/10.1111/tbed.12737.

Foot-and-mouth disease virus 5’-terminal S fragment is required for replication and modulation of the innate immune response in host cells - (Peer Reviewed Journal)
Kloc, A., Diaz-San Segundo, F., Schafer, E.A., Rai, D.K., Kenney, M.A., De Los Santos, T.B., Rieder, A.E. 2017. Foot-and-mouth disease virus 5’-terminal S fragment is required for replication and modulation of the innate immune response in host cells. Virology. 512:132-143.

Genome sequences of seven foot-and-mouth disease virus isolates collected from serial samples from one persistently infected carrier cow in Vietnam - (Peer Reviewed Journal)
Pauszek, S.J., Bertram, M.R., Vu, L.T., Hartwig, E.J., Smoliga, G.R., Brito, B., Stenfeldt, C., Hung, N.T., Hoang, B.H., Rodriguez, L.L., Dung, D.H., Arzt, J. 2017. Genome sequences of seven foot-and-mouth disease virus isolates collected from serial samples from one persistently infected carrier cow in Vietnam. Genome Announcements. 5:e00849-17. https://doi.org/10.1128/genomeA.00849-17.

Enhanced sensitivity in detection of antiviral antibody responses using biotinylation of foot-and-mouth disease virus (FMDV) capsids - (Peer Reviewed Journal)
Kenney, M.A., Waters, R.A., Rieder, A.E., Pega, J., Perez-Filguera, M., Golde, W.T. 2017. Enhanced sensitivity in detection of antiviral antibody responses using biotinylation of foot-and-mouth disease virus (FMDV) capsids. Journal of Immunological Methods. 450:1-9. https://doi.org/10.1016/j.jim.2017.07.001.

Differential replication of foot-and-mouth disease viruses in mice determine lethality - (Peer Reviewed Journal)
Cacciabue, M., Garcia-Nunez, M.S., Delgado, F., Curra, A., Marrero, R., Molinari, P., Rieder, A.E., Carrillo, E., Gismondi, M.I. 2017. Differential replication of foot-and-mouth disease viruses in mice determine lethality. Virology. 509:195-204. doi: 10.1016/j.virol.2017.06.012.

Oncolytic recombinant vesicular stomatitis virus (VSV) is nonpathogenic and non-transmissible in pigs, a natural host of VSV - (Peer Reviewed Journal)
Velazquez-Salinas, L., Niak, S., Peng, K., Pauszek, S.J., Rodriguez, L.L. 2017. Oncolytic recombinant vesicular stomatitis virus (VSV) is nonpathogenic and non-transmissible in pigs, a natural host of VSV. Human Gene Therapy. 28(2):108-115.

Attenuation of foot-and-mouth disease virus by engineered viral polymerase fidelity - (Peer Reviewed Journal)
Rai, D.K., Diaz-San Segundo, F., Campagnola, G., Schafer, E.A., Kloc, A., Keith, A., De Los Santos, T.B., Peersen, O., Rieder, A.E. 2017. Attenuation of foot-and-mouth disease virus by engineered viral polymerase fidelity. Journal of Virology. doi: 10.1128/JVI.00081-17.

Pathogenesis of virulent and attenuated foot and mouth disease virus in cattle - (Peer Reviewed Journal)
Arzt, J., Pacheco Tobin, J., Stenfeldt, C., Rodriguez, L.L. 2017. Pathogenesis of virulent and attenuated foot and mouth disease virus in cattle. Virology. 14(1):89. doi: 10.1186/s12985-017-0758-9.

Disinfection of transboundary animal disease viruses on surfaces in pork packing plants - (Peer Reviewed Journal)
Krug, P.W., Davis, T., O'Brien, C.C., LaRocco, M.A., Rodriguez, L.L. 2018. Disinfection of transboundary animal disease viruses on surfaces in pork packing plants. Veterinary Microbiology. 219:219-225.

First detection of foot-and-mouth disease virus O/Ind-2001d in Vietnam - (Peer Reviewed Journal)
Vu, L.T., Long, N.T., Brito, B., Stenfeldt, C., Phuong, N.T., Hoang, B.H., Pauszek, S.J., Hartwig, E.J., Smoliga, G.R., Vu, P.P., Quang, L.T., Hung, V.V., Tho, N.D., Dong, P.V., Minh, P.Q., Bertram, M.R., Fish, I.H., Rodriguez, L.L., Dung, D.H., Arzt, J. 2017. First detection of foot-and-mouth disease virus O/Ind-2001d in Vietnam. PLoS One. 12(6):e0177361. https://doi.org/10.1371/journal.pone.0177361.

Insights into jumonji c-domain containing protein 6 (JMJD6): a multifactorial role in FMDV replication in cells - (Review Article)
Lawrence, P.J., Rieder, A.E. 2017. Insights into jumonji c-domain containing protein 6 (JMJD6): a multifactorial role in FMDV replication in cells. Virus Genes. 53(3):340-351.

Recombinant human adenovirus-5 expressing capsid proteins of Indian vaccine strains of foot-and-mouth disease virus elicits effective antibody response in cattle - (Peer Reviewed Journal)
Sreenivasa, B.P., Mohapatra, J.K., Pauszek, S.J., Koster, M.J., Dhanya, V.C., Tamil Selvan, R.P., Hosamani, M., Saravanan, P., Basagoudanavar, S.H., De Los Santos, T.B., Venkataramanan, R., Rodriguez, L.L., Grubman, M.J. 2017. Recombinant human adenovirus-5 expressing capsid proteins of Indian vaccine strains of foot-and-mouth disease virus elicits effective antibody response in cattle. Veterinary Microbiology. 203:196-201. doi: 10.1016/j.vetmic.2017.03.019.

Genome sequence of foot-and-mouth disease virus serotype O lineage ind-2001d collected in Vietnam in 2015 - (Peer Reviewed Journal)
Arzt, J., Brito, B.P., Pauszek, S.J., Hartwig, E.J., Smoliga, G.R., Vu, L.T., Vu, P.P., Stenfeldt, C., Rodriguez, L.L., Long, N.T., Dung, D.H. 2017. Genome sequence of foot-and-mouth disease virus serotype O lineage ind-2001d collected in Vietnam in 2015. Genome Announcements. 5(18):e00223-17. doi: 10.1128/genomeA.00223-17.

Interaction between FMDV Lpro and transcription factor ADNP is required for viral replication - (Peer Reviewed Journal)
Medina, G.N., Knudsen, G.M., Greninger, A.L., Kloc, A., Diaz-San Segundo, F., Rieder, A.E., Grubman, M., Derisi, J.L., De Los Santos, T.B. 2017. Interaction between FMDV Lpro and transcription factor ADNP is required for viral replication. Virology. 505:12-22. doi: 10.1016/j.virol.2017.02.010.

Host microRNA-203a is antagonistic to the progression of foot-and-mouth disease virus infection - (Peer Reviewed Journal)
Gutkoska, J., Larocco, M.A., Ramirez-Medina, E., De Los Santos, T.B., Lawrence, P.J. 2017. Host microRNA-203a is antagonistic to the progression of foot-and-mouth disease virus infection. Virology. doi: 10.1016/j.virol.2017.01.019.