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United States Department of Agriculture

Agricultural Research Service

Related Topics

Jonathan Arzt
Foreign Animal Disease Research
Veterinary Medical Science

Phone: (631) 323-4421
Fax: (631) 323-3006

40550 ROUTE 25
ORIENT POINT , NY 11957

Projects
Foot-and-Mouth Disease Surveillance in Vietnam
Cooperative Agreement (A)
  Accession Number: 427390
Ecology and Pathogenesis of Re-Emerging Vesicular Stomatitis Virus (VSV) in North America (Bridge project)
In-House Appropriated (D)
  Accession Number: 431806
Countermeasures to Control and Eradicate Foreign Animal Diseases of Swine
In-House Appropriated (D)
  Accession Number: 431897
Intervention Strategies to Support the Global Control and Eradication of Foot-and-Mouth Disease Virus (FMDV)
In-House Appropriated (D)
  Accession Number: 431980
Foot-and-Mouth Disease Virus Ecology and Surviellance in Vietnam; Exploiting Asymptomatic Carriers to Monitor Field Strains
Interagency Reimbursable Agreement (I)
  Accession Number: 427370
Leveraging Clincal Studies at Plum Island Animal Disease Center to Improve Paramterization of Foreign Animal Disease Models
Interagency Reimbursable Agreement (I)
  Accession Number: 431065
Using Novel Experimental Data to Enhance Modeling of Foreign Animal Disease Threats to Livestock Within the US Homeland.
Interagency Reimbursable Agreement (I)
  Accession Number: 429449
Analysis of duration of immunity of cattle to Ad5-FMD vaccine, the newly licensed vaccine for FMDV
Interagency Reimbursable Agreement (I)
  Accession Number: 424819
Evaluating and Mitigating the Impact of FMDV Persistence in Cattle Subsequent to AD5FMD Vaccination
Interagency Reimbursable Agreement (I)
  Accession Number: 424833
Longitudinal Data and Modeling to Support the Global Control and Eradication of Foot-and-Mouth Disease Virus
Non-Funded Cooperative Agreement (N)
  Accession Number: 430633
Quantitative Analyses of Foot-and-Mouth Disease in Endemic Regions of Asia and Africa
Non-Assistance Cooperative Agreement (S)
  Accession Number: 430966
Longitudinal Study of FMD Vaccinated and Unvaccinated Cattle in Cameroon
Non-Assistance Cooperative Agreement (S)
  Accession Number: 428784
Determination of Duration of Immunity Conferred by Ad5FMDV Vaccination in Cattle
Non-Assistance Cooperative Agreement (S)
  Accession Number: 426604
IN VITRO EVALUATION OF THE CAPACITY OF FOOT-AND-MOUTH DISEASE VIRUS TO INITIATE T-INDEPENDENT HUMORAL RESPONSES IN A BOVINE MODEL
Non-Assistance Cooperative Agreement (S)
  Accession Number: 423165
UNDERSTANDING THE ECOLOGY OF FOOT-AND-MOUTH DISEASE VIRUSES CIRCULATING IN CAMEROON
Non-Assistance Cooperative Agreement (S)
  Accession Number: 423166

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Transcriptomic analysis of persistent infection with foot-and-mouth disease virus in cattle suggests impairment of cell-mediated immunity in the nasopharynx -
Infection dynamics of foot-and-mouth disease virus in cattle following intra-nasopharyngeal inoculation or contact exposure -
Selective factors associated with the evolution of codon usage in natural populations of arboviruses and their practical application to infer possible hosts for emerging viruses -
Velazquez-Salinas, L., Zarate, S., Eschbaumer, M., Lobo, F.P., Gladue, D.P., Arzt, J., Novella, I.S., Rodriguez, L.L. 2016. Selective factors associated with the evolution of codon usage in natural populations of arboviruses and their practical application to infer possible hosts for emerging viruses. PLoS One. PLoS ONE 11(7): e0159943. doi:10.1371/journal.pone.0159943.
The pathogenesis of Foot-and-Mouth Disease in pigs -
Stenfeldt, C., Diaz-San Segundo, F., De Los Santos, T.B., Rodriguez, L.L., Arzt, J. 2016. The pathogenesis of Foot-and-Mouth Disease in pigs. Frontiers in Veterinary Science. 3:41. doi: 10.3389/fvets.2016.00041.
The foot-and-mouth disease carrier state divergence in vaccinated and non-vaccinated cattle -
Stenfeldt, C., Eschbaumer, M., Rekant, S.I., Pacheco, J.M., Smoliga, G.R., Hartwig, E.J., Rodriguez, L.L., Arzt, J. 2016. The foot-and-mouth disease carrier state divergence in vaccinated and non-vaccinated cattle. Journal of Virology. DOI:10.1128/JVL00388-16.
Pathogenesis and micro-anatomic characterization of a cell-adapted mutant foot-and-mouth disease virus in cattle: impact of the Jumonji C-domain containing protein 6 (JMJD6) and route of innoculation -
Lawrence, P.J., Pacheco Tobin, J., Stenfeldt, C., Arzt, J., Rai, D., Rieder, A.E. 2016. Pathogenesis and micro-anatomic characterization of a cell-adapted mutant foot-and-mouth disease virus in cattle: impact of the Jumonji C-domain containing protein 6 (JMJD6) and route of innoculation. Journal of Virology. 492:108-117. doi: 10.1016/j.virol.2016.02.004.
Evaluation of infectivity, virulence and transmission of FDMV field strains of serotypes O and A isolated in 2010 from outbreaks in the Republic of Korea -
Pacheco Tobin, J., Lee, K., Bishop, E.A., Hartwig, E.J., Pauszek, S.J., Smoliga, G.R., Kim, S., Park, J., Ko, Y., Lee, H., Dongseob, T., Cho, I., Kim, B., Rodriguez, L.L., Arzt, J. 2016. Evaluation of infectivity, virulence and transmission of FDMV field strains of serotypes O and A isolated in 2010 from outbreaks in the Republic of Korea. PLoS One. 11(1): e0146445. doi: 10.1371/journal.pone.0146445.
Pathogenesis of primary foot-and-mouth disease virus infection in the nasopharynx of vaccinated and non-vaccinated cattle -
Stenfeldt, C., Eschbaumer, M., Rekant, S.I., Pacheco Tobin, J., Rodriguez, L.L., Arzt, J. 2015. Pathogenesis of primary foot-and-mouth disease virus infection in the nasopharynx of vaccinated and non-vaccinated cattle. PLoS One. 10(11): e0143666. doi: 10.1371/journal.pone.0143666.
An integrative analysis of foot-and-mouth disease virus carriers in Vietnam achieved through targeted surveillance and molecular epidemiology Reprint Icon -
De Carvalho Ferreira, H.C., Pauszek, S.J., Ludi, A., Huston, C.L., Pacheco Tobin, J., Dung, D., Thuy, N., Vu, L., Tho, N., Long, N., Rodriguez, L.L., Arzt, J. 2015. An integrative analysis of foot-and-mouth disease virus carriers in Vietnam achieved through targeted surveillance and molecular epidemiology. Transboundary and Emerging Diseases. doi: 10.1111/tbed.12403.
Subpopulations of bovine T lymphocytes collected during foot-and-mouth disease virus infection are affected by freezing, but are subsequently stable in frozen samples -
Early detection of foot-and-mouth disease virus from infected cattle using a dry filter air sampling system Reprint Icon -
Pacheco Tobin, J., Brito, B., Hartwig, E.J., Smoliga, G.R., Perez, A., Arzt, J., Rodriguez, L.L. 2015. Early detection of foot-and-mouth disease virus from infected cattle using a dry filter air sampling system. Transboundary and Emerging Diseases. doi: 10.1111/tbed.12404.
Deletion of African swine fever virus Georgia 2007 virulence-associated gene 9GL (B119L) leads to virus attenuation in swine at low doses while inducing an effective protection against homologous challenge -
O'Donnell, V., Holinka-Patterson, L.G., Krug, P.W., Gladue, D.P., Carlson, J., Sanford, B.J., Alfano, M., Kramer, E., Lu, Z., Arzt, J., Reese, B., Carrillo, C., Risatti, G., Borca, M.V. 2015. Deletion of African swine fever virus Georgia 2007 virulence-associated gene 9GL (B119L) leads to virus attenuation in swine at low doses while inducing an effective protection against homologous challenge. Journal of Virology. 89(16):8556-8566. DOI: 10.1128/JVI.00969-15.
Veterinary applications of infrared thermography -
Clinical and virological dynamics of a serotype O 2010 South East Asia lineage foot-and-mouth disease virus in sheep using natural and simulated natural inoculation and exposure systems Reprint Icon -
Stenfeldt, C., Pacheco Tobin, J., Singanallur, N.B., De Carvalho Ferreira, H.C., Howey, E.B., Vosloo, W., Rodriguez, L.L., Arzt, J. 2015. Clinical and virological dynamics of a serotype O 2010 South East Asia lineage foot-and-mouth disease virus in sheep using natural and simulated natural inoculation and exposure systems. Veterinary Microbiology. DOI:10.1016/j.vetmic.2015.04.004.
Persistent foot-and-mouth disease virus infection in the nasopharynx of cattle: tissue-specific distribution and local cytokine expression -
Pacheco Tobin, J., Smoliga, G.R., O'Donnell, V., Brito-Rodriguez, B., Stenfeldt, C., Rodriguez, L.L., Arzt, J. 2015. Persistent foot-and-mouth disease virus infection in the nasopharynx of cattle: tissue-specific distribution and local cytokine expression. Virology. DOI:10.1371/journal.pone.0125698.
African swine fever virus Georgia isolate harboring deletions of MGF360 and MGF505 genes is attenuated in swine and confers protection against challenge with the virulent parental virus Reprint Icon -
O'Donnell, V., Holinka-Patterson, L.G., Gladue, D.P., Sanford, B.J., Krug, P.W., Lu, Z., Arzt, J., Reese, B., Carrillo, C., Risatti, G.R., Borca, M.V. 2015. African swine fever virus Georgia isolate harboring deletions of MGF360 and MGF505 genes is attenuated in swine and confers protection against challenge with the virulent parental virus. Journal of Virology. 89(11):6048-6056.
Progressive adaptation of a Georgian isolate of African swine fever virus to vero cells leads to a gradual attenuation of virulence in swine corresponding to major changes of the viral genome Reprint Icon -
Krug, P.W., Holinka-Patterson, L.G., O'Donnell, V., Reese, B., Sanford, B.J., Fernandez-Sainz, I., Gladue, D.P., Arzt, J., Rodriguez, L.L., Risatti, G.R., Borca, M.V. 2014. Progressive adaptation of a Georgian isolate of African swine fever virus to vero cells leads to a gradual attenuation of virulence in swine corresponding to major changes of the viral genome. Journal of Virology. 89(4):2324-2332.
Early events in the pathogenesis of foot-and-mouth disease in pigs; identification of oropharyngeal tonsils as sites of primary and sustained viral replication -
Stenfeldt, C., Pacheco Tobin, J., Rodriguez, L.L., Arzt, J. 2014. Early events in the pathogenesis of foot-and-mouth disease in pigs; identification of oropharyngeal tonsils as sites of primary and sustained viral replication. PLoS One. DOI:10.1371/journal.pone.0106859.
Morphologic and phenotypic characteristics of myocarditis in two pigs infected by foot-and mouth disease virus strains of serotypes O or A -
Stenfeldt, C., Pacheco Tobin, J., Borca, M.V., Rodriguez, L.L., Arzt, J. 2014. Morphologic and phenotypic characteristics of myocarditis in two pigs infected by foot-and mouth disease virus strains of serotypes O or A. Acta Veterinaria Scandinavica. 56(1):42.
Detection of Foot-and-Mouth Disease Virus RNA and capsid protein in lymphoid tissues of convalescent pigs does not indicate existence of a carrier state -
Stenfeldt, C., Pacheco Tobin, J., Smoliga, G.R., Bishop, E.A., Pauszek, S.J., Hartwig, E.J., Rodriguez, L.L., Arzt, J. 2014. Detection of Foot-and-Mouth Disease Virus RNA and capsid protein in lymphoid tissues of convalescent pigs does not indicate existence of a carrier state. Transboundary and Emerging Diseases. DOI: 10.1111/tbed.12235.
Infection dynamics of foot-and-mouth disease virus in pigs using two novel simulated natural inoculation methods Reprint Icon -
Stenfeldt, C., Pacheco Tobin, J., Rodriguez, L.L., Arzt, J. 2014. Infection dynamics of foot-and-mouth disease virus in pigs using two novel simulated natural inoculation methods. Research in Veterinary Science. 96:396-405.
Serotype diversity of Foot-and-Mouth-Disease virus in livestock without history of vaccination in the far north region of Cameroon -
Ludi, A., Ahmed, Z., Pomeroy, L.W., Pauszek, S.J., Smoliga, G.R., Moritz, M., Dickmu, S., Abdoulkadiri, S., Arzt, J., Garabed, R., Rodriguez, L.L. 2014. Serotype diversity of Foot-and-Mouth-Disease virus in livestock without history of vaccination in the far north region of Cameroon. Transboundary and Emerging Diseases. DOI: 10.1111/TBED.12227.
Foot and mouth disease virus virulence in cattle is co-determined by viral replication dynamics and route of infection Reprint Icon -
Arzt, J., Pacheco Tobin, J., Tucker, M.T., Smoliga, G.R., Bishop, E.A., Pauszek, S.J., Hartwig, E.J., De Los Santos, T.B., Rodriguez, L.L. 2014. Foot and mouth disease virus virulence in cattle is co-determined by viral replication dynamics and route of infection. Virology. 452-453:12-22.
Interaction of foot-and-mouth disease virus non-structural protein 3A with host protein DCTN3 is important for viral virulence in cattle -
Gladue, D.P., O'Donnell, V., Baker-Branstetter, R., Pacheco Tobin, J., Holinka-Patterson, L.G., Arzt, J., Pauszek, S.J., Fernandez-Sainz, I., Fletcher, P., Brocchi, E., Lu, Z., Rodriguez, L.L., Borca, M.V. 2014. Interaction of foot-and-mouth disease virus non-structural protein 3A with host protein DCTN3 is important for viral virulence in cattle. Journal of Virology. 88(5):2737-2747.
The pathogenesis of highly virulent African Swine Fever virus in domestic pigs exposed via intraoropharyngeal, intranasopharyngeal, and intramuscular inoculation, and by direct contact with infected pigs Reprint Icon -
Howey, E.B., O'Donnell, V., De Carvalho Ferreira, H.C., Borca, M.V., Arzt, J. 2013. The pathogenesis of highly virulent African Swine Fever virus in domestic pigs exposed via intraoropharyngeal, intranasopharyngeal, and intramuscular inoculation, and by direct contact with infected pigs. Virus Research. 178(2):328-339.
Characterization of a chimeric foot-and-mouth disease virus bearing bovine rhinitis B virus leader proteinase Reprint Icon -
Uddowla, S., Pacheco Tobin, J., Larson, C., Bishop, E.A., Rodriguez, L.L., Rai, D., Arzt, J., Rieder, A.E. 2013. Characterization of a chimeric foot-and-mouth disease virus bearing bovine rhinitis B virus leader proteinase. Virology. 447(1-2):172-180.
A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle Reprint Icon -
Pacheco Tobin, J., Gladue, D.P., Holinka-Patterson, L.G., Arzt, J., Bishop, E.A., Smoliga, G.R., Pauszek, S.J., Bracht, A.J., O'Donnell, V., Fernandez-Sainz, I., Fletcher, P., Piccone, M.E., Rodriguez, L.L., Borca, M.V. 2013. A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle. Virology. 446(1-2):260-267.
Mechanisms of foot-and-mouth disease virus tropism inferred from differential tissue gene expression Reprint Icon -
Zhu, J.J., Arzt, J., Puckette, M.C., Smoliga, G.R., Pacheco Tobin, J., Rodriguez, L.L. 2013. Mechanisms of foot-and-mouth disease virus tropism inferred from differential tissue gene expression. PLoS One. 8(5):e64119. DOI:10.1371/journal.pone.0064119.
Early adaptive immune responses in the respiratory tract of foot and mouth disease-infected cattle Reprint Icon -
Pega, J., Bucafusco, D., Di Giacomo, S., Malacari, D., Capozzo, A., Arzt, J., Perez-Beascoechea, C., Maradei, E., Rodriguez, L.L., Borca, M.V., Perez-Filgueira, M. 2012. Early adaptive immune responses in the respiratory tract of foot and mouth disease-infected cattle. Journal of Virology. 87(5):2489-2495.
Time-dependent biodistribution and transgene expression of a recombinant human adenovirus serotype 5-luciferase vector as a surrogate agent for rAd5-FMDV vaccines in cattle Reprint Icon -
Montiel, N.A., Smoliga, G.R., Arzt, J. 2012. Time-dependent biodistribution and transgene expression of a recombinant human adenovirus serotype 5-luciferase vector as a surrogate agent for rAd5-FMDV vaccines in cattle. Veterinary Immunology and Immunopathology. 151(1-2):37-48. DOI: 110.1016/j.vetimm.2012.10.003.
The early pathogenesis of foot-and-mouth disease -
Arzt, J., Rodriguez, L.L. 2013. The early pathogenesis of foot-and-mouth disease. In: Tipics in Foot and Mouth Disease. Scientific Developments and Technical Challenges in the Progressive Control of Foot-and-Mouth Disease in South Asia, February 13-15, 2012, New Delhi, India. p. 24-36.
Bovine type III interferon significantly delays and reduces the severity of foot-and-mouth disease in cattle Reprint Icon -
Perez-Martin, E., Weiss, M., Diaz San Segundo, F.C., Pacheco Tobin, J., Arzt, J., Grubman, M.J., De Los Santos, T.B. 2012. Bovine type III interferon significantly delays and reduces the severity of foot-and-mouth disease in cattle. Journal of Virology. 86(8):4477-4487.
Direct contact transmission of three different foot-and-mouth disease virus strains in swine demonstrates important strain-specific differences Reprint Icon -
Pacheco Tobin, J., Tucker, M.T., Hartwig, E.J., Bishop, E.A., Arzt, J., Rodriguez, L.L. 2012. Direct contact transmission of three different foot-and-mouth disease virus strains in swine demonstrates important strain-specific differences. The Veterinary Journal. 193(2):456-463.
Foot-and-mouth disease: global status and Indian perspective Reprint Icon -
Biswal, J.K., Sanyal, A., Rodriguez, L.L., Subramaniam, S., Arzt, J., Sharma, G.K., Hammond, J.M., Parida, S., Mohapatra, J.K., Mathapati, B.S., Dash, B.B., Ranjan, R., Rout, M., Venketaramanan, R., Misri, J., Krishna, L., Prasad, G., Pathak, K.M., Pattnaik, B. 2012. Foot-and-mouth disease: global status and Indian perspective. Indian Journal of Animal Sciences. 82(2):109-131.
Early detection and visualization of human adenovirus serotype 5-viral vectors carrying foot-and-mouth disease virus or luciferase transgenes in cell lines and bovine tissues Reprint Icon -
Montiel, N., Smoliga, G.R., Arzt, J. 2012. Early detection and visualization of human adenovirus serotype 5-viral vectors carrying foot-and-mouth disease virus or luciferase transgenes in cell lines and bovine tissues. Vaccine. 30(9):1690-1701.
The pathogenesis of foot-and-mouth disease II; viral pathways in swine, small ruminants, and wildlife, myotropism, chronic syndromes, and molecular virus-host interactions -
Arzt, J., Baxt, B., Grubman, M.J., Jackson, T., Juleff, N., Rhyan, J., Rieder, A.E., Waters, R., Rodriguez, L.L. 2011. The pathogenesis of foot-and-mouth disease II; viral pathways in swine, small ruminants, and wildlife, myotropism, chronic syndromes, and molecular virus-host interactions. Transboundary and Emerging Diseases. 58(4):305-326.
The pathogenesis of foot-and-mouth disease I; viral pathways in cattle -
Arzt, J., Juleff, N., Zhang, Z., Rodriguez, L.L. 2011. The pathogenesis of foot-and-mouth disease I; viral pathways in cattle. Transboundary and Emerging Diseases. 58(4):291-304.
The early pathogenesis of foot-and-mouth disease in cattle after aerosol inoculation -
Arzt, J. 2010. The early pathogenesis of foot-and-mouth disease in cattle after aerosol inoculation [Ph.D. Dissertation]. Ft. Collins, CO: Colorado State University: The Graduate School at Colorado State University. 155 p.
The early pathogenesis of foot-and-mouth disease in cattle after aerosol innoculation: identification of the nasopharynx as the primary site of infection -
Arzt, J., Pacheco Tobin, J., Rodriguez, L.L. 2010. The early pathogenesis of foot-and-mouth disease in cattle after aerosol innoculation: identification of the nasopharynx as the primary site of infection. Veterinary Pathology. 47(6):1048-1063.
Agricultural diseases on the move early in the third millennium -
Arzt, J., White, W.R., Thomsen, B.V., Brown, C.C. 2010. Agricultural diseases on the move early in the third millennium. Veterinary Pathology. 47(1):15-27.
Optimization of immunohistochemical and fluorescent antibody techniques for localization of foot-and-mouth disease virus in animal tissues -
Arzt, J., Gregg, D.A., Clavijo, A., Rodriguez, L.L. 2009. Optimization of immunohistochemical and fluorescent antibody techniques for localization of foot-and-mouth disease virus in animal tissues. Journal of Veterinary Diagnostic Investigation. 21(6):779-792.
Early Events in the Pathogenesis of Foot-and-Mouth Disease in Cattle After Controlled Aerosol Exposure -
Pacheco Tobin, J., Arzt, J., Rodriguez, L.L. 2008. Early Events in the Pathogenesis of Foot-and-Mouth Disease in Cattle After Controlled Aerosol Exposure. The Veterinary Journal. 183(1):46-53.
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Last Modified: 5/2/2016
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