Genome sequences of seven foot-and-mouth disease virus isolates collected from serial samples from one persistently infected carrier cow in Vietnam

Authors: Pauszek, Steven; BERTRAM, MIRANDA - Oak Ridge Institute For Science And Education (ORISE); VU, LE - Ministry Of Agriculture And Rural Development (MARD); Hartwig, Ethan; Smoliga, George; BRITO, BARBARA - Oak Ridge Institute For Science And Education (ORISE); STENFELDT, CAROLINA - Oak Ridge Institute For Science And Education (ORISE); HUNG, NGO - Ministry Of Agriculture And Rural Development (MARD); HOANG, BUI - Ministry Of Agriculture And Rural Development (MARD); Rodriguez, Luis; DUNG, DO - Ministry Of Agriculture And Rural Development (MARD); Arzt, Jonathan

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/12/2017
Publication Date: 8/24/2017
Citation: Pauszek, S.J., Bertram, M.R., Vu, L.T., Hartwig, E.J., Smoliga, G.R., Brito, B., Stenfeldt, C., Hung, N.T., Hoang, B.H., Rodriguez, L.L., Dung, D.H., Arzt, J. 2017. Genome sequences of seven foot-and-mouth disease virus isolates collected from serial samples from one persistently infected carrier cow in Vietnam. Genome Announcements. 5:e00849-17. https://doi.org/10.1128/genomeA.00849-17.

Interpretive Summary: Foot-and-mouth disease (FMD) is an important livestock disease that causes substantial animal health problems in Africa and Asia. FMD virus (FMDV) is the pathogen that causes the disease. Following acute infection, some cattle become persistently infected carriers and shed low levels of the virus for several months to several years without showing any signs of disease. Transmission of FMDV from carrier cattle to healthy cattle has not been conclusively demonstrated. However, depopulation, quarantine, and trade restrictions are imposed following an FMD outbreak, due in part to the perceived risk of transmission from carriers, which have significant economic consequences for the affected region. This brief report contains the first near-complete genetic sequences of seven FMDV viruses obtained from sequential samples of a single carrier animal over the course of one year. These seven viruses show evolution of the virus within the carrier animal. Understanding how FMDV evolves within a carrier animal has important implications for FMDV control.

Technical Abstract: Several FMDV carrier cattle were identified in Vietnam by recovery of infectious virus from oropharyngeal fluid. This report contains the first near-complete genome sequences of seven viruses isolated from a single carrier animal over the course of one year. Understanding within-host viral evolution has implications for designing FMDV control strategies.