Submitted to: Symposium Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 3/25/2012
Publication Date: 1/1/2013
Citation: Arzt, J., Rodriguez, L.L. 2013. The early pathogenesis of foot-and-mouth disease. In: Tipics in Foot and Mouth Disease. Scientific Developments and Technical Challenges in the Progressive Control of Foot-and-Mouth Disease in South Asia, February 13-15, 2012, New Delhi, India. p. 24-36.
Technical Abstract: Understanding the early pathogenesis of foot-and-mouth disease (FMD) is of critical importance to ongoing and future efforts to decrease the impact of FMD in endemic regions and prevent incursions to disease-free territories. The importance of the early phase of virus-host interaction lies in two key facts: 1) it is the early events which determine if a susceptible host becomes infected and 2) successful abrogation of the early events is the logical goal of vaccines and biotherapeutic countermeasures. Ultimately, even population-level trends in movement of FMD viruses (FMDVs) are dependent upon the virus-host interactions which occur in the hours immediately subsequent to individual animals’ exposure to FMDV. In the pages which follow, the scientific literature describing the early pathogenesis of FMD in various host species will be reviewed in detail.