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ARS Home » Northeast Area » Beltsville, Maryland (BHNRC) » Beltsville Human Nutrition Research Center » Diet, Genomics and Immunology Laboratory » People & Locations » Thomas Wang (Tom)

Thomas Ty Wang (Tom)
Diet, Genomics and Immunology Laboratory
Research Leader

Phone: (301) 504-8459 ext. 239
Fax: (304) 504-9062
Room 132

10300 BALTIMORE AVE
BLDG 307-C BARC-EAST
BELTSVILLE, MD 207052350
Projects
Elucidating Phytonutrient Bioavailability, Health Promoting Effects and Mechanisms of Existing/Emerging Foods and Beverages
In-House Appropriated (D)
  Accession Number: 436279
Study of Nutrients Gene Interaction
Interagency Reimbursable Agreement (I)
  Accession Number: 437064
Study of Nutrients Gene Interaction
Interagency Reimbursable Agreement (I)
  Accession Number: 438563
Nutrient Gene Interaction in Prostate Cancer Cells: Effects of I3C/DIM on AhR-Mediated Pathway
Interagency Reimbursable Agreement (I)
  Accession Number: 431013
Immune-Preventive Effects of I3C/DIM in Citrobacter Rodentium-Infected Mouse Model
Interagency Reimbursable Agreement (I)
  Accession Number: 435344
Investigation on Phytochemical and Macronutrient Properties of Soybeans Grown in Romania
Non-Funded Cooperative Agreement (N)
  Accession Number: 429701
Research Partnership with Sichuan University, College of Light Industry, Textile and Food Engineering
Non-Funded Cooperative Agreement (N)
  Accession Number: 431530
Health Promoting Roles of Food Bio-Active Phenolic Compounds on Obesity-Altered Hearth, and Kidney Functions
Non-Assistance Cooperative Agreement (S)
  Accession Number: 431723
Health Promoting Roles of Food Bio-active Phenolic Compounds on Obesity-Altered Metabolic Functions and Physiology
Non-Assistance Cooperative Agreement (S)
  Accession Number: 433533
Studies on the Effects of I3C/DIM on AhR-mediated Pathway
Non-Assistance Cooperative Agreement (S)
  Accession Number: 431475
Cross-Kingdom Regulation Between Dietary Small RNAs and Human Gut Microbiome, and Its Influence on Human Health
Non-Assistance Cooperative Agreement (S)
  Accession Number: 428823
Studies on the Effects of Dietary Bioactive Components on Chronic Disease Prevention
Non-Assistance Cooperative Agreement (S)
  Accession Number: 429208
Study on Immune Modulatory Effects of Cruciferous Vegetable-Derived Bioactive Compounds
Non-Assistance Cooperative Agreement (S)
  Accession Number: 438819
Impact of Food and Particulates on Metabolic Risk
Non-Assistance Cooperative Agreement (S)
  Accession Number: 438888

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Molecular and microbial signatures predictive of prebiotic action of neoagarotetraose in a dextran sulfate sodium-induced murine colitis model Reprint Icon - (Peer Reviewed Journal)
Liu, F., Liu, J., Wang, T.T., Changhu, X., Ziangzhao, M., Qingjuan, T., Li, R.W. 2020. Molecular and microbial signatures predictive of prebiotic action of neoagarotetraose in a dextran sulfate sodium-induced murine colitis model. Microorganisms. 8(7):995. https://doi.org/10.3390/microorganisms8070995.
Javamide-II inhibits IL-6 without significant impact on TNF-alpha and IL-1beta in macrophage-like cells Reprint Icon - (Peer Reviewed Journal)
Park, J.B., Peters, R.C., Pham, Q., Wang, T.T. 2020. Javamide-II inhibits IL-6 without significant impact on TNF-alpha and IL-1beta in macrophage-like cells. BioMedical Journal. 8(6);138. https://doi.org/10.3390/biomedicines8060138.
Plant miRNAs in food alter gut microbiota in a rodent model - (Peer Reviewed Journal)
Mechanistic insights into the attenuation of intestinal inflammation and modulation of the gut microbiome by krill oil using in vitro and in vivo models Reprint Icon - (Peer Reviewed Journal)
Liu, F., Smith, A.D., Solano Aguilar, G., Wang, T.T., Pham, Q., Tang, Q., Urban Jr, J.F., Xue, C., Li, R.W. 2020. Mechanistic insights into the attenuation of intestinal inflammation and modulation of the gut microbiome by krill oil using in vitro and in vivo models. Microbiome. 8:83. https://doi.org/10.1186/s40168-020-00843-8.
Indole-3-carbinol inhibits Citrobacter rodentium infection through multiple pathways including reduction of bacterial adhesion and enhancement of cytotoxic T cell activity Reprint Icon - (Peer Reviewed Journal)
Wu, Y., He, Q., Yu, L., Pham, Q., Cheung, L., Kim, Y.S., Wang, T.T., Smith, A.D. 2020. Indole-3-carbinol inhibits Citrobacter rodentium infection through multiple pathways including reduction of bacterial adhesion and enhancement of cytotoxic T cell activity. Nutrients. 12(4):917. https://doi.org/doi: 10.3390/nu12040917.
Butyrate inhibits deoxycholic-acid-resistant colonic cell proliferation via cell cycle arrest and apoptosis Reprint Icon - (Peer Reviewed Journal)
Zeng, H., Safratowich, B.D., Wang, T.T., Hamlin, S., Johnson, L. 2020. Butyrate inhibits deoxycholic-acid-resistant colonic cell proliferation via cell cycle arrest and apoptosis. Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.201901014.
Chemical composition of cold-pressed blackberry seed flour extract and its potential health-beneficial properties Reprint Icon - (Peer Reviewed Journal)
Choe, U., Li, Y., Gao, B., Yu, L., Wang, T.T., Sun, J., Chen, P., Yu, L. 2020. Chemical composition of cold-pressed blackberry seed flour extract and its potential health-beneficial properties. Food Science and Nutrition. 8(2):1215-1225. https://doi.org/10.1002/fsn3.1410.
Dietary fiber isolated from sweet potato residues promotes healthy gut microbiome profile Reprint Icon - (Peer Reviewed Journal)
Lu, M., Li, X., Zhou, S., Wang, T.T., Zhou, S., Yang, K., Li, Y., Tian, J., Wang, J. 2020. Dietary fiber isolated from sweet potato residues promotes healthy gut microbiome profile. Food and Function. 11, 689-699. https://doi.org/10.1039/c9fo01009b.
Modulation of CXC-motif chemokine receptor 7, but not 4 expression, is related to migration of the human prostate cancer cell LNCaP: regulation by androgen and inflammatory stimuli Reprint Icon - (Peer Reviewed Journal)
Yu, L., Pham, Q., Yu, L., Wang, T.T. 2019. Modulation of CXC-motif chemokine receptor 7, but not 4 expression, is related to migration of the human prostate cancer cell LNCaP: regulation by androgen and inflammatory stimuli. Inflammation Research. 69, 167-178. https://doi.org/10.1007/s00011-019-01305-0.
Effects of rice with different amounts of resistant starch on mice fed a high-fat diet: attenuation of adipose weight gain Reprint Icon - (Peer Reviewed Journal)
Wan, J., Wu, Y., Pham, Q., Yu, L., Chen, M., Boue, S.M., Yokoyama, W.H., Li, B., Wang, T.T. 2019. Effects of rice with different amounts of resistant starch on mice fed a high-fat diet: attenuation of adipose weight gain. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.9b05505.
Malvidin 3-glucoside modulated gut microbial dysbiosis and global metabolome disrupted in a murine colitis model induced by dextran sulfate sodium Reprint Icon - (Peer Reviewed Journal)
Liu, F., Wang, T.T., Tang, Q., Xue, C., Li, R.W., Wu, V.C. 2019. Malvidin 3-glucoside modulated gut microbial dysbiosis and global metabolome disrupted in a murine colitis model induced by dextran sulfate sodium. Molecular Nutrition and Food Research. 1900455:1-14. https://doi.org/10.1002/mnfr.201900455.
The p53 mutation-site in prostate cancer determines its sensitivity to phenethyl isothiocyanate induced growth inhibition Reprint Icon - (Peer Reviewed Journal)
Aggarwal, M., Saxena, R., Asif, N., Sinclair, E., Tan, J., Cruz, I., Berry, D., Kallakury, B., Pham, Q., Wang, T.T., Fung-Lung, C. 2019. The p53 mutation-site in prostate cancer determines its sensitivity to phenethyl isothiocyanate induced growth inhibition. Journal of Experimental and Clinical Cancer Research. 38(1):307. https://doi.org/10.1186/s13046-019-1267-z.
Interactions between food and gut microbiota: Impact on human health Reprint Icon ()
Wu, Y., Wan, J., Choe, U., Pham, Q., Schoene, N., He, Q., Li, B., Yu, L., Wang, T.T. 2019. Interactions between food and gut microbiota: Impact on human health. Annual Review of Food Science & Technology. 10:389-408. https://doi.org/10.1146/annurev-food-032818-121303.
Selected lipid-based transfection reagents activate NF-kB and MAP kinases signaling pathways, induced cytokines mRNA expression in human THP-1 macrophage Reprint Icon - (Peer Reviewed Journal)
Choe, U., Yu, L., Wang, T.T. 2019. Selected lipid-based transfection reagents activate NF-kB and MAP kinases signaling pathways, induced cytokines mRNA expression in human THP-1 macrophage. Analytical Biochemistry: Methods in the Biological Sciences. 573:73-76. https://doi.org/10.1016/j.ab.2019.02.018.
Inhibition of tumor growth by indole-3-carbinol in a prostate cancer xenograft model may be associated with disrupted gut microbial interactions Reprint Icon - (Peer Reviewed Journal)
Wu, Y., Li, R.W., Huang, H., Fletcher, A., Yu, L., Pham, Q., Yu, L., He, Q., Wang, T.T. 2019. Inhibition of tumor growth by indole-3-carbinol in a prostate cancer xenograft model may be associated with disrupted gut microbial interactions. Nutrients. 11(2). pii.E467. https://doi.org/10.3390/nu11020467.
HPLC Quantification and MS/NMR confirmation of Javamide-I/-II in Arabica and Robusta coffee beans from different regions for finding better bean sources for Javamide-I/-II Reprint Icon - (Peer Reviewed Journal)
Park, J.B., Wang, T.T., Zhang, D., Vega, F.E., Meinhardt, L.W. 2019. HPLC Quantification and MS/NMR confirmation of Javamide-I/-II in Arabica and Robusta coffee beans from different regions for finding better bean sources for Javamide-I/-II. Austin Chromatography. 6(1):1051. https://doi.org/10.26420/austinchromatogrl.2019.1051.
The science behind microgreens as an exciting new food for the 21st century Reprint Icon ()
Choe, U., Yu, L., Wang, T.T.Y. 2018. The science behind microgreens as an exciting new food for the 21st century. Journal of Agricultural and Food Chemistry. 7:66(44). https://doi.org/10.1021/acs.jafc.8b03096.
Chemical compositions of cold-pressed broccoli, carrot and cucumber seed flours, and their in vitro gut microbiota modulatory, anti-inflammatory and free radical scavenging properties Reprint Icon - (Peer Reviewed Journal)
Choe, U., Li, Y., Gao, B., Yu, L., Wang, T.T., Sun, J., Chen, P., Liu, J., Yu, L. 2018. Chemical compositions of cold-pressed broccoli, carrot and cucumber seed flours, and their in vitro gut microbiota modulatory, anti-inflammatory and free radical scavenging properties. Journal of Agricultural and Food Chemistry. 66(35):9309-0317. https://doi.org/10.1021/acs.jafc.8b03343.
Suppression of T lymphocyte activation by 3-chloro-1,2-propanediol mono- and di-palmitate esters in vitro Reprint Icon - (Peer Reviewed Journal)
Huang, G., Xue, J., Sun, X., Wang, J., Wang, Y., Wang, T.T., Yu, L. 2018. Suppression of T lymphocyte activation by 3-chloro-1,2-propanediol mono- and di-palmitate esters in vitro. Toxicology In Vitro. 51:54-62. https://doi.org/10.1016/j.tiv.2018.05.002.
Extensive degradation and low bioavailability of orally consumed corn miRNAs in mice Reprint Icon - (Peer Reviewed Journal)
Huang, H., Davis, C., Wang, T.T. 2018. Extensive degradation and low bioavailability of orally consumed corn miRNAs in mice. Nutrients. 10(2)pii: E215. https://doi.org/10.3390/nu10020215.
Elucidating the role of CD84 and AHR in modulation of LPS-induced cytokines production by cruciferous vegetable-derived compounds indole-3-carbinol and 3,3'-diindolylmethane Reprint Icon - (Peer Reviewed Journal)
Wang, T.T., Pham, Q., Kim, Y.S. 2018. Elucidating the role of CD84 and AHR in modulation of LPS-induced cytokines production by cruciferous vegetable-derived compounds indole-3-carbinol and 3,3'-diindolylmethane. International Journal of Molecular Sciences. 19(2):pii:E339. https://doi.org/10.3390/ijms19020339.
Home food preparation techniques impacted the availability of natural antioxidants and bioactivities in kale and broccoli Reprint Icon - (Peer Reviewed Journal)
Yu, L., Gao, B., Li, Y., Wang, T.T., Luo, Y., Wang, J., Yu, L. 2018. Home food preparation techniques impacted the availability of natural antioxidants and bioactivities in kale and broccoli. Food & Function. 9(1):585-593. https://doi.org/10.1039/c7fo00948h.
Gypenosides reduced the risk of overweight and insulin resistance in C57BL/6J mice through modulating adipose thermogenesis and gut microbiota Reprint Icon - (Peer Reviewed Journal)
Liu, Jie, Li, Y., Yang, P., Wan, J., Chang, Q., Wang, T.T., Lu, W., Zhang, Y., Wang, Q., Yu, L. 2017. Gypenosides reduced the risk of overweight and insulin resistance in C57BL/6J mice through modulating adipose thermogenesis and gut microbiota. Journal of Agricultural and Food Chemistry. 65(42):9237-9246. https://doi.org/10.1021/acs.jafc.7b03382.
Gypenosides reduced the risk of overweight and Insulin Resistance in C57BL/6J mice through modulating Adipose Thermagenesis and Gut Microbiota Reprint Icon - (Peer Reviewed Journal)
Liu, J., Li, Y., Yang, P., Wan, J., Zhang, Y., Gao, B., Wang, Z., Wang, T.T., Yu, L. 2017. Gypenosides reduced the risk of overweight and Insulin Resistance in C57BL/6J mice through modulating Adipose Thermagenesis and Gut Microbiota. Journal of Food Science and Nutrition. 65(42)9237-9246. https://doi.org/doi: 10.1021/acs.jafc.7b03382.
Transcriptional and translational-uncoupling in regulation of the CXCL12 and its receptors CXCR4, 7 in THP-1 monocytes and macrophages Reprint Icon - (Peer Reviewed Journal)
Yu, L., Pham, Q., Yu, L., Wang, T.T. 2018. Transcriptional and translational disconnect in regulation of the CXCL12 and its receptors CXCR4, 7 in THP-1 monocytes and macrophages. Immunity, Inflammation and Disease Journal. 6(1):106-116. https://doi.org/10.1002/iid3.199.
Dose-dependent responses of I3C and DIM on T-cell activation in the human T lymphocyte Jurkat cell line Reprint Icon - (Peer Reviewed Journal)
Liu, M., Yasmeen, R., Fukagawa, N.K., Yu, L., Kim, Y.S., Wang, T.T. 2017. Dose-dependent responses of I3C and DIM on T-cell activation in the human T lymphocyte Jurkat cell line. International Journal of Molecular Sciences. 18(7). pii: E1409. https://doi.org/10.3390/ijms18071409.
Methyl (E)-(3,4-dihydroxyphenyl)acryloyl)tryptophanate can suppress MCP-1 expression by inhibiting p38 MAP kinase and NF-kB in LPS-stimulated differentiated THP-1 cells Reprint Icon - (Peer Reviewed Journal)
Park, J.B., Wang, T.T. 2017. Methyl (E)-(3,4-dihydroxyphenyl)acryloyl)tryptophanate can suppress MCP-1 expression by inhibiting p38 MAP kinase and NF-kB in LPS-stimulated differentiated THP-1 cells. European Journal of Pharmacology. 8(10):149-155.. https://doi.org/10.1016/j.ejphar.2017.07.006.
Inhibitory effect of piceatannol on TNF-a mediated inflammation and insulin resistance in 3T3-L1 adipocytes Reprint Icon - (Peer Reviewed Journal)
Li, Y., Yang, P., Chang, Q., Wang, J., Liu, J., Yuan, L., Wang, T.T., Gao, B., Yu, L. 2017. Inhibitory effect of piceatannol on TNF-a mediated inflammation and insulin resistance in 3T3-L1 adipocytes. Journal of Agricultural and Food Chemistry. 65(23). https://doi.org/10.1021/acs.jafc.7b01567.
An improved method to quantitate mature plant microRNA in biological matrices using periodate treatment and internal control - (Peer Reviewed Journal)
Huang, H, Roh, J., Davis, C., Wang, T.T. 2017. An improved method to quantitate mature plant microRNA in biological matrices using periodate treatment and internal control. PLoS One. 12(4):e0175429. doi: 10.1371/journal.pone.0175429.
Absorption, distribution, metabolism and excretion of 3-MCPD 1-monopalmitate after oral administration in rats Reprint Icon - (Peer Reviewed Journal)
Gao, B., Liu, M., Huang, G., Zhang, Z., Zhao, Y., Wang, T.T., Zhang, Y., Liu, J., Yu, L. 2018. Absorption, distribution, metabolism and excretion of 3-MCPD 1-monopalmitate after oral administration in rats. Journal of Agricultural and Food Chemistry. 65(12):2609-2614. https://doi.org/10.1021/acs.jafc.7b00639.
Home-based preparation approaches altered the availability of health beneficial components from carrot and blueberry Reprint Icon - (Peer Reviewed Journal)
Gao, B., Yu, L., Liu, J., Wang, T.T., Luo, Y., Yu, L., Zhang, H., Gong, L. 2017. Home-based preparation approaches altered the availability of health beneficial components from carrot and blueberry. Journal of Food Science and Nutrition. (42):9237-9246. https://doi.org/10.1002/fsn3.462.
Establishing health benefits of bioactive food components: a basic research scientist's perspective ()
Yasmeen, R., Fukagawa, N.K., Wang, T.T. 2017. Establishing health benefits of bioactive food components: a basic research scientist's perspective. Current Opinion in Biotechnology. 44:109-114. doi: 10.1016/j.copbio.2016.11.016.
Red cabbage microgreens lower circulating LDL, liver cholesterol and inflammatory cytokines in mice fed a high fat diet - (Peer Reviewed Journal)
Jiang, X., Huang, H., Xiao, Z., Yu, L., Pham, Q., Yokoyama, W.H., Yu, L., Luo, Y., Wang, T.T. 2016. Red cabbage microgreens lower circulating LDL, liver cholesterol and inflammatory cytokines in mice fed a high fat diet. Journal of Agricultural and Food Chemistry. 64(48):9161-9171.
Soy and gut microbiota: interaction and implication for human health - (Peer Reviewed Journal)
Huang, H., Krishnan, H.B., Pham, Q., Yu, L.L., Wang, T.T. 2016. Soy and gut microbiota: interaction and implication for human health. Journal of Agricultural and Food Chemistry. 64(46):8695-8709.
Reversible toxic effects of the dietary supplement Indole-3-Carbinol in an immune compromised rodent model: intestine as the main target - (Peer Reviewed Journal)
Fletcher, A.R., Huang, H., Yu, L., Pham, Q., Yu, L., Wang, T.T. 2017. Reversible toxic effects of the dietary supplement Indole-3-Carbinol in an immune compromised rodent model: Intestine as the main target. Journal of Dietary Supplement. 14:(3):303-322. doi: 10.1080/19390211.
Preparation of five 3-MCPD fatty acid esters and the effects of their chemical structures on acute oral toxicity in Swiss mice - (Peer Reviewed Journal)
Liu, M., Liu, J., Wu, Y., Gao, B., Wu, P., Shi, H., Sun, X., Huang, H., Wang, T.T., Yu, L. 2016. Preparation of five 3-MCPD fatty acid esters and the effects of their chemical structures on acute oral toxicity in Swiss mice. Journal of Food Chemistry. doi: 10.1002/jsfa.7805.
Components characterization of total tetraploid jiaogulan (Gynostemma pentaphylla) saponin and its cholesterol-lowering properties - (Peer Reviewed Journal)
Liu, J., Li, Y., Haiming, S., Wang, T.T., Wu, X., Sun, X., Yu, L. 2016. Components characterization of total tetraploid jiaogulan (Gynostemma pentaphylla) saponin and its cholesterol-lowering properties. Journal of Functional Foods. 23: 542-555.
3-MCPD 1-palmitate induced renal tubular cell apoptosis in vivo via JNK/p53 pathway - (Peer Reviewed Journal)
Liu, M., Huang, G., Wang, T.T., Sun, X., Yu, L. 2016. 3-MCPD 1-palmitate induced renal tubular cell apoptosis in vivo via JNK/p53 pathway. Toxicological Sciences. 151(1):181-92. doi: 10.1093/toxsci/lfw033.
Identification of liver CYP51 as a gene responsive to circulating cholesterol in a hamster model - (Peer Reviewed Journal)
Huang, H., Xie, Z., Yokoyama, W.H., Yu, L., Wang, T.T. 2016. Identification of liver CYP51 as a gene responsive to circulating cholesterol in a hamster model. Journal of Nutritional Science. doi: 10.1017/jns.2016.3eCollection2016.
An effective and simple procedure to isolate abundant quantities of biologically active chemopreventive lunasin-protease inhibitor concentrate (LPIC) from soybean Reprint Icon - (Peer Reviewed Journal)
Krishnan, H.B., Wang, T.T. 2015. An effective and simple procedure to isolate abundant quantities of biologically active chemopreventive lunasin-protease inhibitor concentrate (LPIC) from soybean. Food Chemistry. 177:120-126.
The cellular uptake and transport of zein nanoparticles: Effect of sodium caseinate - (Peer Reviewed Journal)
Luo, Y., Teng, Z., Wang, T.T., Wang, Q. 2013. The cellular uptake and transport of zein nanoparticles: Effect of sodium caseinate. Journal of Agricultural and Food Chemistry. 61(31):7621-9.
Feeding probiotic Lactobacillus paracasei to Ossabaw pigs on a high fat diet prevents cholesteryl-ester accumulation and LPS modulation of the Liver X receptor and inflammatory axis in alveolar macrophages - (Peer Reviewed Journal)
Trasino, S.E., Dawson, H.D., Urban Jr, J.F., Wang, T.T., Solano Aguilar, G. 2013. Feeding probiotic Lactobacillus paracasei to Ossabaw pigs on a high fat diet prevents cholesteryl-ester accumulation and LPS modulation of the Liver X receptor and inflammatory axis in alveolar macrophages. Journal of Nutritional Biochemistry. 24(11):1931-1939.
Cholesterol-lowering activity of soy-derived glyceollins in the golden Syrian hamster model - (Peer Reviewed Journal)
Huang, H., Xie, Z., Boue, S.M., Bhatnagar, D., Yokoyama, W.H., Yu, L.L., Wang, T.T. 2013. Cholesterol-lowering activity of soy-derived glyceollins in the golden Syrian hamster model. Journal of Agricultural and Food Chemistry. 61(24):35772-5782.
Indole-3-carbinol and 3’, 3’-diindolylmethane modulate androgen effect up-regulation on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells - (Peer Reviewed Journal)
Kim, E.K., Kim, Y.S., Milner, J.A., Wang, T.T. 2013. Indole-3-carbinol and 3’, 3’-diindolylmethane modulate androgen effect up-regulation on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells. Cancer Prevention Research. 6(6):519-529.
Development and application of nanoparticles synthesized with folic acid-conjugated soy protein - (Peer Reviewed Journal)
Teng, Z., Luo, Y., Wang, T.T., Zanh, B., Wang, Q. 2013. Development and application of nanoparticles synthesized with folic acid-conjugated soy protein. Journal of Agricultural and Food Chemistry. 61(10):2556-64.
Encapsulation of indole-3-carbinol and 3'3'-diindolylmethane in zein/carboxymethyl chitosan nanoparticles with controlled release property and improved stability - (Peer Reviewed Journal)
Lou, Y., Wang, T.T., Teng, Z., Chen, P., Sun, J., Wang, Q. 2013. Encapsulation of indole-3-carbinol and 3'3'-diindolylmethane in zein/carboxymethyl chitosan nanoparticles with controlled release property and improved stability. Food Chemistry. 139(1-4):224-30.
Strong and weak plasma response to dietary carotenoids identified by cluster analysis and linked to beta-carotene 15,15'-monooxygenase 1 single nucleotide polymorphisms - (Peer Reviewed Journal)
Wang, T.T., Edwards, A.J., Clevidence, B.A. 2013. Strong and weak plasma response to dietary carotenoids identified by cluster analysis and linked to beta-carotene 15,15'-monooxygenase 1 single nucleotide polymorphisms. Journal of Nutritional Biochemistry. 24(8):1538-1546.
Characterization of lipopolysaccharide-stimulated cytokine expression in macrophages and monocytes - (Peer Reviewed Journal)
Huang, H., Fletcher, A., Niu, Y., Wang, T.T., Yu, L. 2012. Characterization of lipopolysaccharide-stimulated cytokine expression in macrophages and monocytes. Inflammation Research. 61(12):1329-1338.
Safflomide increases the expression of adiponectin in vitro and in vivo: Implication for hypoadiponectemia, visceral obesity, and insulin resistance - (Peer Reviewed Journal)
Park, J.B., Wang, T.T. 2012. Safflomide increases the expression of adiponectin in vitro and in vivo: Implication for hypoadiponectemia, visceral obesity, and insulin resistance. Journal of Agricultural and Food Chemistry. 25(60):4048-52.
Inhibition of soybean seeds in warm water results in the release of copious amounts of Bowman-Birk protease inhibitor, a putative anticarcinogenic agent - (Peer Reviewed Journal)
Palavalli, M.H., Natarajan, S.S., Wang, T.T., Krishnan, H.B. 2012. Inhibition of soybean seeds in warm water results in the release of copious amounts of Bowman-Birk protease inhibitor, a putative anticarcinogenic agent. Journal of Agricultural and Food Chemistry. 60:3135-3143.
Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in the androgen-responsive prostate cancer cell LNCaP - (Peer Reviewed Journal)
Wang, T.T., Schoene, N.W., Kim, E.K., Kim, Y.S. 2012. Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in the androgen-responsive prostate cancer cell LNCaP. Molecular Carcinogenesis. DOI:10.1002/mc.21906.
Transcriptomic alterations in human prostate cancer cell LNCaP tumor xenograft modulated by dietary phenethyl isothiocyanate - (Peer Reviewed Journal)
Li, R.W., Li, C., Wang, T.T. 2012. Transcriptomic alterations in human prostate cancer cell LNCaP tumor xenograft modulated by dietary phenethyl isothiocyanate. Molecular Carcinogenesis. DOI: 10.1002/mc.21873.
The protective effect of soybean phytochemicals on androgen responsive human prostate cancer cells LNCaP is likely mediated through modulation of hormone/cytokine-dependent pathways - (Peer Reviewed Journal)
Wang, T.T., Boue, S.M., Krishnan, H.B. 2011. The protective effect of soybean phytochemicals on androgen responsive human prostate cancer cells LNCaP is likely mediated through modulation of hormone/cytokine-dependent pathways. Functional Foods in Health and Disease. 1(11):457-471.
Chemical composition, and anti-proliferative and anti-inflammatory effects of the leaf and wholeplant samples of diploid and tetraploid gynostemma pentaphyllum - (Peer Reviewed Journal)
Xie, Z., Huang, H., Zhao, Y., Shi,, H., Wang, S., Wang, T.T., Chen, P., Yu, L. 2011. Chemical composition, and anti-proliferative and anti-inflammatory effects of the leaf and wholeplant samples of diploid and tetraploid gynostemma pentaphyllum. Food Chemistry. 132:125-133.
A role for p53 in selenium-induced senescence - (Peer Reviewed Journal)
Wu, M., Wu, R., Wang, T.T., Cheng, W. 2011. A role for p53 in selenium-induced senescence. Journal of Agricultural and Food Chemistry. 591:1182-1187.
Dietary phenethyl isothiocyanate inhibition of androgen-responsive LNCaP prostate cancer cell tumor growth correlates with decreased angiogenesis - (Peer Reviewed Journal)
Hudson, T., Perkins, S., Hursting, S., Young, H., Kim, Y., Wang, T., Wang, T.T. 2011. Dietary phenethyl isothiocyanate inhibition of androgen-responsive LNCaP prostate cancer cell tumor growth correlates with decreased angiogenesis. International Journal of Oncology. 40:1113-1121.
Isolation and characterization of two flavonoids, engeletin and astilbin, from the leaves of Engelhardia roxburghiana, and their potential anti-inflammatory properties - (Peer Reviewed Journal)
Huang, H., Cheng, Z., Shi, H., Xin, W., Wang, T.T., Yu, L. 2011. Isolation and characterization of two flavonoids, engeletin and astilbin, from the leaves of Engelhardia roxburghiana, and their potential anti-inflammatory properties. Journal of Agricultural & Food Chemistry. 59(9):4562-9.
Broccoli-derived phytochemicals indole-3-carbinol and 3,3’-diindolylmethane exert concentration-dependent pleiotropic effects on prostate cancer cells: Comparison with other cancer preventive phytochemicals - (Peer Reviewed Journal)
Wang, T.T., Schoene, N.W., Milner, J.A., Kim, Y.S. 2011. Broccoli-derived phytochemicals indole-3-carbinol and 3,3’-diindolylmethane exert concentration-dependent pleiotropic effects on prostate cancer cells: Comparison with other cancer preventive phytochemicals. Molecular Carcinogenesis. DOI: 10.1002/mc.20774.
Chemical composition of five commercial gynostemma pentaphyllum samples and their radical scavenging, antiproliferative, and anti-inflammatory properties - (Peer Reviewed Journal)
Xie, Z., Liu, W., Huang, H., Slavin, M., Zhao, Y., Whent, M., Blackford, J., Lutterodt, H., Zhou, H., Chen, P., Wang, T.T., Liangli, Y. 2010. Chemical composition of five commercial gynostemma pentaphyllum samples and their radical scavenging, antiproliferative, and anti-inflammatory properties. Journal of Agricultural and Food Chemistry. 58(21):11243-11249.
Effect of resveratrol and zinc on intracellular zinc status in normal human prostate epithelial cells - (Peer Reviewed Journal)
Zhang, J., Wu, M., Schoene, N.W., Cheng, W., Wang, T.T., Alshatwi, A.A., Alsaif, M., Lei, K.Y. 2009. Effect of resveratrol and zinc on intracellular zinc status in normal human prostate epithelial cells. American Journal of Physiology - Cell Physiology. 297(3):C632-644.
Differential effects of resveratrol and its methylether analogs on cell cycle and apoptosis in human androgen-responsive LNCaP cancer cells - (Peer Reviewed Journal)
Wang, T.T., Schoene, N.W., Kim, Y.S., Mizuno, C.S., Rimando, A.M. 2010. Differential effects of resveratrol and its methylether analogs on cell cycle and apoptosis in human androgen-responsive LNCaP cancer cells. Molecular Nutrition and Food Research. 54(3):335-344.
Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells - (Peer Reviewed Journal)
Trasino, S.E., Kim, Y.S., Wang, T.T. 2009. Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells. Molecular Cancer Therapeutics. 8(7):1934-1945.
Selenoprotein W Modulates Control of Cell Cycle Entry - (Peer Reviewed Journal)
Hawkes, W.C., Wang, T.T., Alkan, Z., Richter, D., Dawson, K. 2009. Selenoprotein W Modulates Control of Cell Cycle Entry. Humana Press Inc, Biological Trace Element Research. 131:229-244.
Molecular effects of soy phytoalexin glyceollins in human prostate cancer cells LNCaP - (Peer Reviewed Journal)
Payton-Stewart, F., Schoene, N.W., Kim, Y.S., Burrow, M.E., Cleveland, T.E., Boue, S.M., Wang, T.T. 2009. Molecular effects of soy phytoalexin glyceollins in human prostate cancer cells LNCaP. Molecular Carcinogenesis. 48(9):862-871.
Differential effects of resveratrol on androgen-responsive LNCaP human prostrate cancer cells in vitro and in vivo. - (Peer Reviewed Journal)
Wang, T.T., Hudson, T.S., Wang, T.C., Remsberg, C.M., Davies, N.M., Takahashi, Y., Kim, Y.S., Seifried, H., Vinyard, B.T., Perkins, S.N., Hursting, S.D. 2008. Differential effects of resveratrol on androgen-responsive LNCaP human prostrate cancer cells in vitro and in vivo. Carcinogenesis. 29(10):2001-2010.
Concentration-dependent effects of genistein on global gene expression in MCF-7 breast cancer cells: an oligo microarray study. - (Peer Reviewed Journal)
Lavigne, J.A., Takahashi, Y., Chandramouli, G.V., Liu, H., Shih, J., Perkins, S.N., Hursting, S.D., Barrett, J., Wang, T.T. 2007. Concentration-dependent effects of genistein on global gene expression in MCF-7 breast cancer cells: an oligo microarray study. Breast Cancer Research and Treatment. [DOI 10.1007/s10549-007-9705-6].
Inhibition of prostate cancer growth by muscadine grapeskin extract and resveratrol through distinct mechanisms - (Peer Reviewed Journal)
Hudson, T.S., Hartle, D.K., Hursting, S.D., Nunez, N.P., Wang, T.T., Young, H.A., Arany, P., Green, J.E. 2007. Inhibition of prostate cancer growth by muscadine grapeskin extract and resveratrol through distinct mechanisms. Cancer Research. 67(17):8396-8405.
Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in androgen responsive human prostate cancer cell LNCaP. - (Peer Reviewed Journal)
Trasino, S.E., Harrison, E.H., Wang, T.T. 2007. Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in androgen responsive human prostate cancer cell LNCaP. Experimental Biology and Medicine (Maywood). 232(6):762-771.
MOLECULAR SIGNATURES OF SOY-DERIVED PHYTOCHEMICALS IN ANDROGEN-RESPONSIVE PROSTATE CANCER CELLS: A COMPARISON STUDY USING DNA MICROARRAY - (Peer Reviewed Journal)
Takahashi, Y., Lavigne, J.A., Hursting, S.D., Chandramouli, G.V., Perkins, S.N., Kim, Y.S., Wang, T.T. 2006. Molecular signatures of soy-derived phytochemicals in androgen-responsive prostate cancer cells: a comparison study using dna microarray. Molecular Carcinogenesis. 12:943-956.
ENHANCED ESTROGENIC RESPONSES AND SENSITIVITY TO AZOSYMETHANE FOLLOWING DIETARY SOY ISOFLAVONE SUPPLEMENTATION IN OLDER FEMALE RATS - (Peer Reviewed Journal)
Daly, K.T., Tracy, A.C., Malik, M., Wang, T.T., Francke-Carroll, S., Magnuson, B.A. 2007. Enhanced estrogenic responses and sensitivity to azosymethane following dietary soy isoflavone supplementation in older female rats. Food and Chemical Toxicology. 45(4):628-637.
17BETA-ESTRADIOL DIFFERENTIALLY REGULATES ANDROGEN-RESPONSIVE GENES THROUGH AN ESTROGEN RECEPTOR-BETA-DEPENDENT PATHWAY IN LNCAP HUMAN PROSTATE CANCER CELLS - (Peer Reviewed Journal)
Takahashi, Y., Hursting, S.D., Perkins, S.N., Wang, T.T. 2007. 17beta-estradiol differentially regulates androgen-responsive genes through an estrogen receptor-beta-dependent pathway in lncap human prostate cancer cells. Molecular Carcinogenesis. E-publication. 46(2):117-129.
DECIPHERING MOLECULAR SIGNATURES OF PHYTOCHEMICALS IN CELLS - (Proceedings)
Wang, T.T., Kim, Y.S., Hursting, S.D., Perkins, S.N., Gadisetti, C.R., Lavigne, J.A., Takahashi, Y. 2005. Deciphering molecular signatures of phytochemicals in cells. UJNR Food & Agricultural Panel Proceedings.
GENISTEIN AFFECTS ANDROGEN-RESPONSIVE GENES THROUGH BOTH ANDROGEN RECEPTOR- AND ESTROGEN RECEPTOR-MEDIATED PATHWAYS - (Peer Reviewed Journal)
Takahashi, Y., Hursting, S.D., Perkins, S.N., Wang, T.T. 2006. Genistein affects androgen-responsive genes through both androgen receptor- and estrogen receptor-mediated pathways. Molecular Carcinogenesis. 45:18-25.
PHYTOCHEMICALS AS MODULATOR OF APOPTOSIS PATHWAYS - (Proceedings)
Wang, T.T., Wang, T., Kim, Y.S., Hursting, S.D., Perkins, S.N., Lavigne, J.A., Leh, Y., Takahashi, Y. 2004. Phytochemicals as modulator of apoptosis pathways. United Stats/Japan Nutrition Research (UJNR) Food and Agricultural Panel Proceedings. p.149-152.
USING DNA MICROARRAY ANALYSES TO ELUCIDATE THE EFFECTS OF GENISTEIN IN ANDROGEN-DEPENDENT PROSTATE CANCER CELLS: IDENTIFICATION OF NOVEL TARGETS FOR CANCER PREVENTION - (Peer Reviewed Journal)
Takahashi, Y., Lavigne, J.A., Hursting, S.D., Chandramouli, G.V., Perkins, S.N., Barrett, C., Wang, T.T. 2004. Using dna microarray analyses to elucidate the effects of genistein in androgen-dependent prostate cancer cells: identification of novel targets for cancer prevention. Molecular Carcinogenesis, Vol. 1 (2), pp. 108-119.
NUMERICAL DECONVOLUTION OF CDNA MICROARRAY SIGNAL - (Peer Reviewed Journal)
Rosenfeld, S., Wang, T.T.Y., Young, K., and Milner, J. Numerical deconvolution of cDNA microarray signal, Ann. N.Y. Acad. Sci., 1020:110-123, 2004.
UTIITY OF MICROARRAY TECHNOLOGY IN STUDIES OF CANCER PREVENTIVE PHYTOCHEMICALS (ABSTRACT, US-JAPAN NATURAL RESOURCES PANEL MEETING, TSUKUBA, JAPAN, NOVEMBER 7-15, 2003) - (Abstract Only)
Wang, T.T., Lavigne, J.A., Hursting, D.S., Chandramouli, G.V.R., Takahashi, Y. 2003. Utillity of microarray technology in studies of cancer preventive phytochemicals. Proceedings of the 32nd Annual Meeting of the United States-Japan Natural Resources Food and Agriculture Panel Members Meeting, Tsukuba, Japan. 304-307.
SOY ISOFLAVONE GENISTEIN MODULATES EXPRESSION OF AN ANDROGEN-RESPONSIVE GENE SPAK IN HUMAN PROSTATE CANCER (US-JAPAN NATURAL RESOURCES PANEL MEETING, TSUKUBA, JAPAN, NOVEMBER 7-15, 2003) - (Abstract Only)
Takahashi, Y., Hursting, D.S., Wang, T.T. 2003. Soy isoflavone genistein modulates expression of an androgen-respnsive gene SPAK in human prostate cancer cells. Proceedings of the 32nd Annual Meeting of the United States-Japan Natural Resources Food and Agriculture Panel Members, Tsukuba, Japan. 313-315.
GENISTEIN-INDUCED APOPTOSIS IN MCF-7 CELLS INVOLVES CHANGES IN BAK AND BEL-X WITHOUT EVIDENCE OF ANTI-OESTROGENIC EFFECTS - (Peer Reviewed Journal)
BETA-NAPHTHOFLAVONE, AN INDUCER OF XENOBIOTIC METABOLIZING ENZYMES, I LUCIFERASE ACTIVITY - (Peer Reviewed Journal)
Wang, T.T. 2002. Beta-naphthoflavone, an inducer of xenobiotic metabolizing enzymes,inhibits luciferase activity. Analytical Biochemistry. 304:122-126.
LOW DOSE GENISTEIN INDUCES CYCLIN-DEPENDENT KINASE INHIBITORS AND G1 CELL CYCLE ARREST IN HUMAN PROSTATE CANCER CELLS - (Peer Reviewed Journal)
MODULATION OF CYCLOPHILIN GENE EXPRESSION BY N-4-(HYDROXYPHENYL) RETINAMIDEASSOCIATION WITH REACTIVE OXYGEN SPECIES GENERATION AND APOPTOSIS - (Peer Reviewed Journal)
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