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Title: PHYTOCHEMICALS AS MODULATOR OF APOPTOSIS PATHWAYS

Author
item WANG, THOMAS - Tom
item WANG, TIEN-CHUNG - 1235-05-00
item KIM, YOUNG - NCI/NIH,BETHESDA,MD
item HURSTING, STEVEN - NCI/NIH,BETHESDA,MD
item PERKINS, SUSAN - NCI/NIH,BETHESDA,MD
item LAVIGNE, JACKIE - NCI/NIH,BETHESDA,MD
item LEH, YEN - NAT'L FOOD RES.GRP,JAPAN
item TAKAHASHI, YOKO - NAT'L FOOD RES.GRP,JAPAN

Submitted to: UJNR Food & Agricultural Panel Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 11/1/2004
Publication Date: 12/20/2004
Citation: Wang, T.T., Wang, T., Kim, Y.S., Hursting, S.D., Perkins, S.N., Lavigne, J.A., Leh, Y., Takahashi, Y. 2004. Phytochemicals as modulator of apoptosis pathways. United Stats/Japan Nutrition Research (UJNR) Food and Agricultural Panel Proceedings. p.149-152.

Interpretive Summary: Interpretive summary not required for seminar proceedings.

Technical Abstract: A role for diet-derived phytochemicals in prevention of various forms of cancers including breast and prostate cancer have been suggested. However, the mechanisms underlying the beneficial effects of phytochemicals remain largely unclear. We hypothesize that phytochemicals can exert effects on multiple cellular pathways. We reason that an effect on the apoptosis pathways may contribute to cancer preventive effects of phytochemicals. Our current efforts focus on identifying molecular targets for phytochemicals within the apoptosis pathway that may support our hypothesis.