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ARS Home » Northeast Area » Beltsville, Maryland (BHNRC) » Beltsville Human Nutrition Research Center » Diet, Genomics and Immunology Laboratory » Research » Publications at this Location » Publication #347011
Title: Gypenosides reduced the risk of overweight and insulin resistance in C57BL/6J mice through modulating adipose thermogenesis and gut microbiota

Author
item LIU, JIE - Beijing Advanced Innovation Center For Food Nutrition And Human Health, Beijing Technology & Busine
item LI, YANFANG - Shanghai Jiaotong University
item YANG, PUYU - Shanghai Jiaotong University
item WAN, JIANCHUN - Shanghai Jiaotong University
item CHANG, QIMENG - Fudan University
item Wang, Thomas - Tom
item LU, WEIYING - Shanghai Jiaotong University
item ZHANG, YAQIONG - Shanghai Jiaotong University
item WANG, QUNG - University Of Maryland
item YU, LIANGLI - University Of Maryland

Submitted to: Journal of Agricultural and Food Chemistry
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/4/2017
Publication Date: 10/4/2017
Citation: Liu, Jie, Li, Y., Yang, P., Wan, J., Chang, Q., Wang, T.T., Lu, W., Zhang, Y., Wang, Q., Yu, L. 2017. Gypenosides reduced the risk of overweight and insulin resistance in C57BL/6J mice through modulating adipose thermogenesis and gut microbiota. Journal of Agricultural and Food Chemistry. 65(42):9237-9246. https://doi.org/10.1021/acs.jafc.7b03382.
DOI: https://doi.org/10.1021/acs.jafc.7b03382

Interpretive Summary: Jiaogulan is a Chinese medicinal plant, often consumed as tea, that contains bioactive phytochemicals such as gypenosides. This study investigated whether and how gypenosides from jiaogulan tea at 100 and 300 mg/kg/d levels could reduce the development of overweight and insulin resistance in C57 BL/6J mice fed a high-fat diet in 12 weeks. The 300 mg/kg/d gypenosides supplement significantly reduced final body weight, plasma total cholesterol and homeostasis model assessment-estimated insulin resistance (HOMA-IR) index by 19.9, 40 and 36%, respectively, compared with the high-fat diet control group. Gypenosides also increased brown adipocyte tissue activity and white adipose tissue browning. The expression of genes involved in mitochondrial activity and fatty acid ß-oxidation were also increased in both brown and white adipocyte tissues. In addition, gypenosides at 100 and 300 mg/kg/d levels decreased the ratio of Firmicutes to Bacteroidetes by 20% and 58.6%, respectively, and increased Akkermansia muciniphila abundance in the gut microbiota. This study provides information about the health promoting effects of plant-derived compounds and their effects on gut microbiome. The work provides information that can benefit basic, as well as translation scientists working on diet, gut microbiome and health promotion.

Technical Abstract: This study investigated whether and how gypenosides from jiaogulan tea at 100 and 300 mg/kg/d levels could reduce the development of overweight and insulin resistance in C57 BL/6J mice fed a high-fat diet in 12 weeks. The 300 mg/kg/d gypenosides supplement significantly reduced final body weight, plasma total cholesterol and homeostasis model assessment-estimated insulin resistance (HOMA-IR) index by 19.9, 40 and 36%, respectively, compared with the high-fat diet control group. Gypenosides also increased brown adipocyte tissue activity and white adipose tissue browning. The expression of genes involved in mitochondrial activity and fatty acid ß-oxidation were also increased in both brown and white adipocyte tissues. In addition, gypenosides at 100 and 300 mg/kg/d levels decreased the ratio of Firmicutes to Bacteroidetes by 20% and 58.6%, respectively, and increased Akkermansia muciniphila abundance in the gut microbiota.