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ARS Home » Plains Area » Clay Center, Nebraska » U.S. Meat Animal Research Center » Genetics, Breeding, and Animal Health Research » Research » Research Project #432111

Research Project: Genomic Intervention Strategies to Prevent and/or Treat Respiratory Diseases of Ruminants

Location: Genetics, Breeding, and Animal Health Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Longitudinal study of humoral immunity to bovine coronavirus, virus shedding, and treatment for bovine respiratory disease in pre-weaned beef calves - (Peer Reviewed Journal)
Workman, A.M., Kuehn, L.A., Mcdaneld, T.G., Clawson, M.L., Loy, J.D. 2019. Longitudinal study of humoral immunity to bovine coronavirus, virus shedding, and treatment for bovine respiratory disease in pre-weaned beef calves. BioMed Central (BMC) Veterinary Research. 15:161. https://doi.org/10.1186/s12917-019-1887-8.

Impact of CD46 knockout on bovine viral diarrhea virus (BVDV) replication in Madin-Darby bovine kidney cells - (Abstract Only)

A host-associated antimicrobial agent exhibits both immunoprotective and immunotherapeutic effects - (Abstract Only)

A bovine CD18 signal peptide variant with increased binding activity to Mannheimia hemolytica leukotoxin - (Peer Reviewed Journal)
Workman, A.M., Chitko-Mckown, C.G., Smith, T.P.L., Bennett, G.L., Kalbfleisch, T.S., Basnayake, V., Heaton, M.P. 2018. A bovine CD18 signal peptide variant with increased binding activity to Mannheimia hemolytica leukotoxin. F1000Research. 7:1985. https://doi.org/10.12688/f1000research.17187.1.

Whole genome sequencing of Moraxella bovoculi reveals high genetic diversity and evidence for interspecies recombination at multiple loci - (Peer Reviewed Journal)

Evaluation of EPAS1 variants for association with bovine congestive heart failure - (Abstract Only)

First complete genome sequence of a genotype A2, subgroup 4 small ruminant lentivirus - (Peer Reviewed Journal)
Workman, A.M., Clawson, M.L., Heaton, M.P., Dickey, A.M. 2018. First complete genome sequence of a genotype A2, subgroup 4 small ruminant lentivirus. MICROBIOLOGY RESOURCE ANNOUNCEMENTS. 7(19):e01337-18. https://doi.org/10.1128/MRA.01337-18.

Correlates of cross-protective immunity to porcine reproductive and respiratory syndrome virus - (Abstract Only)

Structure-guided identification of a non-human morbillivirus with zoonotic potential - (Peer Reviewed Journal)

Closed genome sequences and antibiograms of 16 pasteurella multocida isolates from bovine respiratory disease complex cases and apparently healthy controls - (Peer Reviewed Journal)
Harhay, G.P., Harhay, D.M., Bono, J.L., Smith, T.P.L., Capik, S.F., DeDonder, K.D., Apley, M.D., Lubbers, B.V., White, B.J., Larson, R.L. 2018. Closed genome sequences and antibiograms of 16 pasteurella multocida isolates from bovine respiratory disease complex cases and apparently healthy controls. MICROBIOLOGY RESOURCE ANNOUNCEMENTS. 7(11):e00976-18. https://doi.org/10.1128/MRA.00976-18.

Complete genome sequence of Moraxella bovis strain Epp63, an etiologic agent of infectious bovine keratoconjunctivitis - (Peer Reviewed Journal)
Loy, J.D., Dickey, A.M., Clawson, M.L. 2018. Complete genome sequence of Moraxella bovis strain Epp63, an etiologic agent of infectious bovine keratoconjunctivitis. Microbiology Resource Announcements. 7(8):1-2. https://doi.org/10.1128/MRA01004.18.

Cardiopulmonary remodeling in fattened beef cattle: A naturally occurring large animal model of obesity-associated pulmonary hypertension with left heart disease - (Peer Reviewed Journal)

Development of a multiplex real-time PCR assay using two thermocycling platforms for detection of major bacterial pathogens associated with bovine respiratory disease complex from clinical samples - (Peer Reviewed Journal)

Genomic signatures of a Mannheimia haemolytica lineage associated with bovine respiratory disease - (Abstract Only)

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry identification of Moraxella bovoculi and Moraxella bovis isolates from cattle - (Peer Reviewed Journal)
Robbins, K., Dickey, A.M., Clawson, M.L., Loy, J.D. 2018. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry identification of Moraxella bovoculi and Moraxella bovis isolates from cattle. Journal of Veterinary Diagnostic Investigation. p. 1-4. Available: jvdi.sagepub.com. https://doi.org/10.1177/1040638718789725.

A SNP resource for studying North American moose - (Peer Reviewed Journal)
Kalbfleisch, T.S., Murdoch, B.M., Smith, T.P.L., Murdoch, J.D., Heaton, M.P., Mckay, S.D. 2018. A SNP resource for studying North American moose. F1000Research. 7(40):1-17. https://doi.org/10.12688/f1000research.13501.1.

The Wnt signaling pathway is differentially expressed during the bovine herpesvirus 1 latency-reactivation cycle: evidence that two protein kinases associated with neuronal survival (Akt3 and bone morphogenetic protein.... - (Peer Reviewed Journal)
Workman, A.M., Zhu, L., Keel, B.N., Smith, T.P.L., Jones, C. 2018. The Wnt signaling pathway is differentially expressed during the bovine herpesvirus 1 latency-reactivation cycle: evidence that two protein kinases associated with neuronal survival (Akt3 and bone morphogenetic protein receptor 2) are expressed at higher levels during latency. Journal of Virology. 92:e01937-17. https//doi.org/10.1128/JVI.01937-17.

Development of a broadly protective modified-live virus vaccine candidate against porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)
Sun, H., Workman, A., Osorio, F.A., Steffen, D., Vu, H.L.X. 2017. Development of a broadly protective modified-live virus vaccine candidate against porcine reproductive and respiratory syndrome virus. Vaccine. 36:66-73. https://doi.org/10.1016/j.vaccine.2017.11.028.

Development and characterization of a bovine monocyte-derived macrophage cell line - (Abstract Only)

Molecular and epidemiological characterization of a respiratory disease outbreak in pre-weaned beef calves associated with bovine coronavirus - (Abstract Only)

Closed genome sequences of seven histophilus somni isolates from beef calves with bovine respiratory disease complex - (Peer Reviewed Journal)
Harhay, G.P., Harhay, D.M., Bono, J.L., Smith, T.P.L., Capik, S.F., DeDonder, K.D., Apley, M.D., Lubbers, B.V., White, B.J., Larson, R.L. 2017. Closed genome sequences of seven histophilus somni isolates from beef calves with bovine respiratory disease complex. Genome Announcements. 5(40):e01099-17. https://doi.org/10.1128/genomeA.01099-17.

Phenotyping and susceptibility of established porcine cells lines to African swine fever virus infection and viral production - (Peer Reviewed Journal)
Sanchez, E.G., Riera, E., Nogal, M., Gallardo, C., Fernandez, P., Bello-Morales, R., Lopez-Guerrero, J., Chitko-McKown, C.G., Richt, J.A., Revilla, Y. 2017. Phenotyping and susceptibility of established porcine cells lines to African swine fever virus infection and viral production. Scientific Reports. 7:10369. https://doi.org/10.1038/s41598-017-09948-x.

Using sheep genomes from diverse U.S. breeds to identify missense variants in genes affecting fecundity Reprint Icon - (Peer Reviewed Journal)
Heaton, M.P., Smith, T.P.L., Freking, B.A., Workman, A.M., Bennett, G.L., Carnahan, J.K., Kalbfleisch, T.S. 2017. Using sheep genomes from diverse U.S. breeds to identify missense variants in genes affecting fecundity. F1000Research. 6:1303. https://doi.org/10.12688/f1000research.12216.1.

Closed genomes and phenotypes of seven Histophilus somni isolates from beef calves with bovine respiratory disease complex - (Abstract Only)
Harhay, G.P., Harhay, D.M., Bono, J.L., Smith, T.P., Heaton, M.P., Clawson, M.L., Chitko-McKown, C.G., Capik, S.F., DeDonder, K.D., Apley, M.D., Lubbers, B.V., White, B.J., Larson, R.L. 2017. Closed genomes and phenotypes of seven Histophilus somni isolates from beef calves with bovine respiratory disease complex [Abstract]. American Society for Microbiology Microbe Meeting, June 1-5, 2017, New Orleans, LA. Poster #Sunday-869.

Complete genome sequences of two genotype A2 small ruminant lentiviruses isolated from infected U.S. sheep - (Peer Reviewed Journal)
Workman, A.M., Dickey, A.M., Heaton, M.P., Clawson, M.L., Smith, T.P.L. 2017. Complete genome sequences of two genotype A2 small ruminant lentiviruses isolated from infected U.S. sheep. Genome Announcements. 5(13):e00109-17.