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United States Department of Agriculture

Agricultural Research Service

Research Project: Genomic Intervention Strategies to Prevent and/or Treat Respiratory Diseases of Ruminants

Location: Genetics, Breeding, and Animal Health Research

Title: Closed genomes of seven histophilus somni isolates from beef calves with bovine respiratory disease complex

Author
item Harhay, Gregory
item Capik, Sarah
item Dedonder, Keith
item Apley, Michael
item Lubbers, Brian
item White, Bradley
item Larson, Robert

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/6/2017
Publication Date: N/A
Citation: N/A

Interpretive Summary: Bovine respiratory disease complex outbreaks in feed yard cattle are the primary drivers of disease-related antibiotic treatments and have a global impact estimated to be greater than $USD 3 billion/year. Histophilus somni is a disease-causing bacterium that affects multiple organ systems and is one of the principle species contributing to bovine respiratory disease complex (BRDC) in feed yard cattle. There is a need for more publicly available H. somni closed genomes because only two were available in GenBank as of January 2016. These closed genomes provide important information to veterinary microbiologists and other veterinary medical professionals about H. somni’s potential to cause disease.

Technical Abstract: Histophilus somni is a fastidious gram-negative opportunistic pathogenic Pasteurellacea that affects multiple organ systems and is one of the principle bacterial species contributing to bovine respiratory disease complex (BRDC) in feed yard cattle. Here we present seven closed genomes isolated from three beef calves showing sign of BRDC.

Last Modified: 09/21/2017
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