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ARS Home » Plains Area » Clay Center, Nebraska » U.S. Meat Animal Research Center » Animal Health Genomics » Research » Publications at this Location » Publication #354894
Research Project: Genomic Intervention Strategies to Prevent and/or Treat Respiratory Diseases of Ruminants

Location: Animal Health Genomics

Title: Closed genome sequences and antibiograms of 16 pasteurella multocida isolates from bovine respiratory disease complex cases and apparently healthy controls

Author
item Harhay, Gregory
item Harhay, Dayna
item Bono, James - Jim
item Smith, Timothy - Tim
item CAPIK, SARAH - Texas A&M Agrilife
item DEDONDER, KEITH - Veterinary And Biomedical Research Center, Inc
item APLEY, MICHAEL - Kansas State University
item LUBBERS, BRIAN - Kansas State University
item WHITE, BRADLEY - Kansas State University
item LARSON, ROBERT - Kansas State University

Submitted to: Microbiology Resource Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/22/2018
Publication Date: 9/20/2018
Citation: Harhay, G.P., Harhay, D.M., Bono, J.L., Smith, T.P.L., Capik, S.F., DeDonder, K.D., Apley, M.D., Lubbers, B.V., White, B.J., Larson, R.L. 2018. Closed genome sequences and antibiograms of 16 pasteurella multocida isolates from bovine respiratory disease complex cases and apparently healthy controls. Microbiology Resource Announcements. 7(11):e00976-18. https://doi.org/10.1128/MRA.00976-18.
DOI: https://doi.org/10.1128/MRA.00976-18

Interpretive Summary: Bovine respiratory disease complex (BRDC) outbreaks in feed yard cattle are the primary drivers of disease-related antibiotic treatments and have a global impact estimated to be greater than $USD 3 billion/year. We present sixteen closed genomes of Pasteurella multocida and their antimicrobial resistance profiles isolated from calves with BRDC and pen mates not showing signs of BRDC. These data that we release to the public can be used by researchers to improve their understanding of how Pasteurella multocida genomic factors affect antimicrobial resistance and their role in the development of respiratory disease in cattle. Since Pasteurella multocida is associated with disease in other livestock species, companion animals, and in rare cases, humans, this data set may be relevant to understanding Pasteurella multocida infections in these species too.

Technical Abstract: Pasteurella multocida is an animal-associated Gram-negative member of the Pasteurellaceae family. It is an opportunistic pathogen and is one of the principal bacterial species contributing to bovine respiratory disease complex (BRDC) in feedlot cattle. We present 16 closed genome sequences and antibiograms of isolates cultured from calves exhibiting clinical signs of BRDC and from control calves not showing signs of BRDC.