Location: Animal Health Genomics
Title: In search of a genetic cause for heart failure in beef cattleAuthor
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Submitted to: Meeting Abstract
Publication Type: Abstract Only Publication Acceptance Date: 8/20/2018 Publication Date: 8/27/2018 Citation: Heaton, M.P. 2018. In search of a genetic cause for heart failure in beef cattle. [abstract online]. Available: http://www.vbms.unl.edu. Interpretive Summary: Technical Abstract: Cattle feedlots in the Western Plains are experiencing significant losses to pulmonary hypertension and right heart failure. Referred to locally as “brisket disease”, this disorder is occurring at moderate altitudes (4000 ft) in otherwise well managed cattle with high genetic merit. For some operations, brisket disease is their largest single cause of mortality, and economic losses may exceed $250,000 annually. The brisket disease of Western Plains feedlots has features that appear to distinguish it from the well-known High Mountain brisket disease that occurs at 8000 ft. In the latter, specific missense variants in the EPAS1 gene, encoding the hypoxia inducible transcription factor (HIF)2A, have been reported to be genetic risk factors for the disease. We tested eight EPAS1 missense variants for association with clinical heart failure cases from Western Plains feedlots in a matched case-control design with 102 pairs from three locations. The results show that none of these EPAS1 variants are associated with this disease and indicate that a genome-wide association study may be justified. |
