Phone: (309) 681-6195
1815 N University
Peoria, IL 61604
Dr. Ramirez’s research interests include the study of arthropod-borne pathogen systems particularly, the identification of factors that influence pathogen infection and the elucidation of novel mechanisms to control vector populations and prevent pathogen transmission. Current efforts in the laboratory builds upon the integration of knowledge gathered from the study of the multipartite organismal interactions (host-pathogen-symbiotic microbe) to develop new microbe-based biopesticides for use against arthropod vectors of human and plant pathogens.
Biological control of mosquitoes and other vector-borne arthropods, arbovirology, insect immunity and pathology, entomopathogenic microbes and host-pathogen interactions, arthropod-borne pathogen systems
2011 Ph.D., Molecular Microbiology and Immunology Johns Hopkins University
2006 M.Sc., Entomology University of California Riverside
2002 B.Sc., Zoology Idaho State University
2016- Present Research Entomologist, Crop Bioprotection Research Unit, USDA, ARS, Peoria, IL
2011 – 2015 Postdoctoral Research Fellow, Lab. Of Malaria and Vector Research, NIAID, NIH, Bethesda, MD
American Society for Microbiology
American Association for the Advancement of Science
Entomological Society of America
Society for Invertebrate Pathology
HONORS AND AWARDS
2015 NIH Fellows Award for Research Excellence 2015
National Institutes of Health
2015 Keystone Symposia Future of Science Fund Scholarship
Scholarship to attend and present at the meeting on The Arthropod Vector: The Controller of Transmission.
2015 Gordon Research Conference Fellowship.
Fellowship to attend and present at the Tropical Infectious Diseases Conference Gordon Research Conferences
2012 Intramural NIAID Research Opportunities (INRO) Fellowship
NIAID/ National Institutes of Health
2011 The Richard and Mary Finkelstein Student Travel Grant
111th General Meeting, American Society for Microbiology.
2010 Young Researcher participant in the 60th Interdisciplinary Meeting of Nobel Laureates at Lindau.
Council for the Lindau Nobel Laureate Meetings. Lindau, Germany.
2010 Robert Bosch- ESOF Fellowship to attend the Euroscience Open Forum 2010. Torino, Italy.
Robert Bosch Stiftung GmbH, Euroscience Open Forum (ESOF).
2010 Best Poster Presentation. 1st Place. Delta Omega Scientific Poster Competition.
Delta Omega Society. Bloomberg School of Public Health. Johns Hopkins University.
2009 Ruth L. Kirschstein National Research Service Awards For Individual Predoctoral Fellowships (F31).
National Institute of Health / National Institute of Allergy and Infectious Diseases.
2008 Global Health Field Research Award
The Johns Hopkins Bloomberg School of Public Health Support to conduct dengue virus-related field research in Panama.
2008 ASM - Robert D. Watkins Graduate Research Fellowship
American Society for Microbiology
2007 The A. Ralph and Sylvia E. Barr Fellowship in Vector Biology
Department of Molecular Microbiology and Immunology. The Johns Hopkins Bloomberg School of Public Health
2006 Diversity and Health Disparities Predoctoral Fellow.
The Johns Hopkins Bloomberg School of Public Health
2005 Best M.S. Poster Presentation. 12th Annual Student Seminar Day
Department of Entomology. University of California Riverside
2003-05 University of California Riverside College Fellowship Award. Department of Entomology, UC Riverside.
2002 Outstanding Undergraduate Biology Research Presentation. Undergraduate Research Symposium
Department of Biological Sciences. Idaho State University
Invited Conference Lectures and Departmental Seminars
2016 Invited Oral presentation: “Mosquito, Pathogens, and Symbiotic microbes: Multipartite Molecular Interactions Shaping Vector Competence,” Illinois State University, Bloomington IL
2016 Invited Lecture: “The interplay between mosquitoes, viruses and humans: the case of Zika and other arboviral diseases, ” Osher Lifelong Learning Institute. Bradley University, Peoria, IL
2016 Invited Oral presentation: “The Mosquito Battlefield: Understanding the Mosquito’s Molecular Weaponry against Pathogens,” Tyson Summer Seminar Series. Tyson Research Center, Washington University, St. Louis, Missouri
2016 Invited Oral presentation: “Vector-Borne Diseases: New and Re-emerging infectious diseases affecting Public Health,” “International Health at a local level,” Association for Professionals in Infection Control and Epidemiology. Chapter #48 - Bloomington, IL
2015 Oral presentation: “Molecular Mechanisms Mediating Innate Immune Priming in An. gambiae mosquitoes.” Keystone Symposia: The Arthropod Vector: the Controller of Transmission. Taos, New Mexico.
2015 Oral presentation: “Lipocalin / lipoxin complex mediates immune priming in An. gambiae mosquitoes,” Gordon Research Symposium: Tropical Infectious Diseases. Galveston, Texas
2015 Invited Oral presentation: “The parasite-vector war: molecules mediating immune priming in mosquitoes,” American Society for Microbiology and George Mason University. Fairfax, Virginia
2015 Poster presentation: “Molecular interactions modulating immune priming in An. gambiae mosquitoes,” Gordon Research Conference: Tropical Infectious Diseases. Galveston, Texas
2015 Oral presentation: “Molecular mechanisms of Immune Priming in An. gambiae mosquitoes: Lipocalin/lipoxin driving innate immune priming in mosquitoes, “ Malaria and Vector Biology Interest Group Seminar. NIAID, NIH.
2014 Invited Oral presentation: “Primed for war: innate immune priming defines the outcome of the mosquito-malaria parasite fight,” Intramural NIAID Research Opportunities Program, INRO 2014. NIAID, NIH. Bethesda, Maryland.
2014 Oral presentation: “Molecular mechanisms of Immune Priming in An. gambiae mosquitoes,” Malaria and Vector Biology Interest Group Seminar. NIAID, NIH.
2014 Poster Presentation: "Insights into the molecular mechanisms of immune priming in An. Gambiae mosquitoes." 2014 NIH Research Festival . NIH Bethesda, Maryland.
2013 Poster presentation: “Molecular Mechanism of Innate Immune Memory in An. gambiae mosquitoes,” American Society of Tropical Medicine and Hygiene. 62nd Annual Meeting, Washington, D.C.
2013 Oral presentation: “Molecular mechanisms of Innate Immune Memory in An. gambiae mosquitoes,” Malaria and Vector Biology Interest Group Seminar. NIAID, NIH.
2013 Oral presentation: “Immune pathways and hemocyte differentiation in mosquito-Plasmodium interactions,” Intramural NIAID Research Opportunities Program. INRO 2013. NIAID, NIH. Bethesda, Maryland
2012 Poster presentation: “Hemocyte differentiation in Innate Immune Memory under the regulation of Immune signaling pathways,” US-Brazil Vector Symposium. Rocky Mountain Laboratories, Hamilton, Montana
2011 Young Investigator/Student Oral Presentation: “Mosquito-Microbiome Molecular Interactions Define Dengue Virus Infection Dynamics,” ASM 111th General Meeting, New Orleans, Louisiana
2010 Poster presentation: “Mosquito-microbiome interactions influencing dengue virus infection,” Jose Luis Ramirez, Jayme A. Souza-Neto and George Dimopoulos. ASM 110th General Meeting, San Diego, California
2010 Poster presentation: “The Toll pathway is a conserved immune defense active against different dengue serotypes and present in multiple Aedes aegypti strains.” Delta Omega Scientific Poster Competition. Johns Hopkins Bloomberg School of Public Health.
2010 Poster presentation: “Mosquito, dengue virus, bacteria: tripartite interactions determining dengue virus transmission,” Jose Luis Ramirez and George Dimopoulos. Global Health Day, Johns Hopkins Center for Global Health.
2009 Poster presentation: “The Toll pathway is a conserved immune defense active against different dengue serotypes and present in multiple Aedes aegypti strains.” Jose Luis Ramirez and George Dimopoulos. 58th Annual Meeting, Washington, D.C.
2009 Poster presentation: “Implication of the Innate Immune Defense in the anti-dengue defense at the early stages of infection,” Jose Luis Ramirez and George Dimopoulos. ASM 109th General Meeting, Philadelphia, Pennsylvania.
2009 Invited Oral presentation: “Mosquito, dengue virus, bacteria: tripartite interactions determining dengue virus transmission,” Jose Luis Ramirez and George Dimopoulos. Gorgas Memorial Institute, Panama City, Panama
2007 Oral presentation: “Dissecting the Aedes aegypti anti-Dengue immune response,” Jose Luis Ramirez, Zhiyong Xi and George Dimopoulos. American Society of Tropical Medicine and Hygiene. 56th Annual Meeting, Philadelphia, Pennsylvania
2005A Poster presentation: “The Effect of Post-Acquisition Hosts on the Presence of Xylella fastidiosa in GWSS Saliva,” Jose L. Ramirez, P.T. Lacava, T.M. Perring and T. A. Miller. 2005 Pierce’s Disease Research Symposium, CDFA, San Diego, California
2005B Poster presentation: “Fate of Xylella fastidiosa and a genetically modified bacterium in the foregut of Homalodisca coagulata fed on citrus and grape host plants,” Jose L. Ramirez and T. A. Miller. 12th Annual Student Seminar Day. Department of Entomology, University of California Riverside
2005C Oral Presentation: “The Big Sagebrush(Artemisia tridentata): Home of a Rich Arthropod Fauna.” José L. Ramirez & Nancy Huntly. Great Rift Science Symposium. Idaho State University, Pocatello, Idaho.
2005D Oral Presentation: “The Diversity,Abundance, and Trophic Structure of Arthropods on Sagebrush (Artemisia tridentata) of Craters of the Moon NM and a Nearby Agricultural Region.” José L. Ramirez et al. Great Rift Science Symposium. Idaho State University, Pocatello, Idaho.
2004A Poster presentation: “Fitness of a Genetically Modified Symbiont upon Reintroduction to its Host, the Glassy-Winged Sharpshooter (Homalodisca coagulata).” Jose L. Ramirez, B. Bextine, and T. A. Miller. 2004 Entomological Society of America Annual Meeting. Salt Lake City, Utah.
2004B Oral Presentationn: “Pathogen and Symbiont Interactions in the Glassy-winged Sharpshooter (Homalodisca coagulata).” J.L Ramirez and T. A. Miller. 11th Annual Student Seminar Day. Department of Entomology. University of California, Riverside
2002 Poster presentation: “Paternity Analysis of Burying Beetles to Determine Alternative Mating Behaviors.” Jose L. Ramirez, J. McKay, R. Williams, and R. Smith. Undergraduate Research Symposium, ISU.
Ramirez J.L., Giselle de Almeida Oliveira, Eric Calvo, Jose Ribeiro, Charles Serhan Carolina Barillas-Mury. 2015 “A Mosquito Lipocalin/Eicosanoid Complex Mediates Innate Immune Memory in Anopheles gambiae mosquitoes” Nature Communications 6, Article number: 7403 doi:10.1038/ncomms8403
Molina-Cruz A., Canepa G.E., Kamath N., Mu J., Ramphul U., Ramirez J.L., Barillas-Mury C. 2015 “Global Plasmodium falciparum transmission involves pfs47-mediated evasion of Mosquito Immunity.” PNAS 112(49):201520426
Ramirez J.L; Short S M; Bahia AC; Saraiva R G; Dong Y; Kang S; Tripathi A; Mlambo G;Dimopoulos G. 2014 "
Chromobacterium Csp_P Reduces Malaria and Dengue Infection in Vector Mosquitoes and Has
Entomopathogenic and In Vitro Anti-pathogen Activities. PLoS Pathog 10(10): e1004398.
Chagas AC, Ramirez JL, Jasinskiene N, James AA, Ribeiro JM, Marinotti O, & Calvo E. 2014 “Collagen-binding protein, Aegyptin, regulates probing time and blood feeding success in the dengue vector mosquito, Aedes aegypti”. Proc. Natl. Acad Sci USA. 111(19):6946-51. Doi: 10.1073/pnas.1404179111
Shuzhen S, Cirimotich C.M., Ramirez J.L., Souza-Neto J.A. and Dimopoulos G. 2014. Dengue Virus-Mosquito Interactions and Molecular methods of Vector Control. In Dengue and Dengue Hemorrhagic Fever. 2nd Edition. Eds D.J. Gubler et al.
Padrón A., Molina-Cruz A, Quinones M, Ribeiro JM, Ramphul U, Rodrigues J, Shen K, Haile A, Ramirez JL, Barillas-Mury C. 2014 “In depth annotation of the Anopheles gambiae mosquito midgut transcriptome” BMC genomics 07/2014; 15(1):636. DOI: 10.1186/1471-2164-15-636
Ramirez JL, Garver LS, Brayner FA, Alves LC, Rodrigues J, Molina-Cruz A and Barillas Mury C. 2014 “The role of hemocytes in An. gambiae antiplasmodial immunity”. J. Innate. Immun. (DOI:10.1159/000353765).
Sim S., Jupatanakul N., Ramirez JL, Kang S., Romero-Vivas C.M., Mohammed H., Dimopoulos G. 2013. “Transcriptomic profiling of diverse Aedes aegypti strains reveals increased basal-level immune activation in dengue virus-refractory populations and identifies novel virus-vector molecular interactions”. PLoS Neglected Trop Dis. 7(7): e2295. doi:10.1371/journal.pntd.0002295
Ramirez JL, Souza-Neto J, Cosme RT, Rovira J, Ortiz A, Pascale JM and Dimopoulos G. 2012. Reciprocal Tripartite
Interactions between the Aedes aegypti Midgut Microbiota, Innate Immune System and Dengue Virus Influences
Vector Competence PLoS Neglected Trop Dis. 6(3): e1561
Sim S, Ramirez JL, Dimopoulos G. 2012. Dengue Virus Infection of the Aedes aegypti Salivary Gland and
Chemosensory Apparatus Induces Genes that Modulate Infection and Blood-Feeding Behavior. PLoS Pathog 8(3): e1002631.
Cirimotich CM, Ramirez JL and Dimopoulos G. 2011. Native microbiota shape insect vector competence for
human pathogen. Review, Cell Host & Microbe. (Vol. 10, Issue 4, pp. 307-310).
Dong Y., Morton J.C., Ramirez J.L., Souza-Neto J.A., Dimopoulos G. 2011. The entomopathogenic fungus
Beauveria bassiana activate toll and JAK-STAT pathway controlled effector genes and anti-dengue activity in
Aedes aegypti. Insect Biochemistry and Molecular Biology. DOI: 10.1016/j.ibmb.2011.11.005
Ramirez JL and Dimopoulos G. 2010. “The Toll immune signaling pathway is an important component of the anti-dengue defense repertoire with conserved activity across diverse Ae. aegypti strains and against multiple dengue virus serotypes” J. Dev. Comp. Immunol. 34:6 625-629.
Hughes GL, Ren X, Ramirez JL, Sakamoto JM, Bailey JA, Jedlicka AE and Rasgon JL. 2011 “Wolbachia infections in Anopheles gambiae cells: transcriptomic characterization of a novel host-symbiont interaction.” PLoS Pathogens. 7(2)
Bartholomay LC, Waterhouse RM, Mayhew GF, Campbell CL, Michel K, Zou Z, Ramirez JL, Das S, Alvarez K, Arensburger P, Bryant B, Chapman SB, Dong Y, Erickson SM, Karunaratne SH, Kokoza V, Kodira CD, Pignatelli P, Shin SW, Vanlandingham DL, Atkinson PW, Birren B, Christophides GK, Clem RJ, Hemingway J, Higgs S, Megy K, Ranson H, Zdobnov EM, Raikhel AS, Christensen BM, Dimopoulos G, Muskavitch MA. 2010. “Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens.” Science. 330(6000):88-90.
Ramirez, J.L., L. Garver and G. Dimopoulos 2009. “Challenges and Approaches for Mosquito Targeted Malaria Control”. Current Molecular Medicine. 9:116-130.
Erickson SA, Xi Z, Mayhew GF, Ramirez JL, Aliota MT, Christensen BM, Dimopoulos G 2009. Mosquito Infection Responses to Developing Filarial Worms. PLoS Neglected Tropical Diseases. 3(10): e529
Sim S, Ramirez JL, and Dimopoulos G. 2009. Molecular discrimination of mosquito vectors and their pathogens. Expert Review of Molecular Diagnostics. 9: 757-765
Sessions OM, Barrows, NJ, Souza-Neto JA, Robinson TJ, Hershey CL, Rodgers MA, Ramirez JL, Dimopoulos G, Yang PL, Pearson JL, Garcia-Blanco MA. 2009. “Discovery of Dengue Virus Host Factors in Insects and Humans” Nature. 458:1047-1050.
Zhiyong X., J.L. Ramirez and G. Dimopoulos. 2008. “The Toll pathway controls Dengue infection in Aedes aegypti” .PLoS Pathogens, 4(7)).
Ramirez J. L., T. M. Perring and T. A. Miller. 2008. “Fate of a Genetically Modified Bacterium in the Foregut of Glassy-winged sharpshooter” J Econ. Entomol. 101:1519-1525
Ramirez J. L., P.T. Lacava and T. A. Miller. 2008. “Detection of Xylella fastidiosa in saliva of the Glassy-Winged Sharpshooter (Homalodisca coagulata)”. Journal of Insect Science. 8:34
Lacava, P.T., J. Parker, F.D. Andreote, F. Dini-Andreote, J.L. Ramirez, and T.A. Miller 2007. “Analysis of bacterial community inhabiting glassy-winged sharpshooter foregut acessed by culture-dependent techniques and PCR-DGGE”. Entomological Research, 37, 261-266.
Dimopoulos G., S. Das, L. Garver, J.L. Ramirez and Z. Xi 2007. “Protocol for dengue infections in mosquitoes (A. Aegypti) and infection phenotype determination. Journal of Visualized Experiments. http://www.jove.com/index/details.stp?ID=220