|FERREIRA, ANNA BEATRIZ - National Institutes Of Health (NIH)|
|BARILLAS-MURRY, CAROLINA - National Institutes Of Health (NIH)|
Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 1/30/2017
Publication Date: 5/5/2017
Citation: Ramirez, J.L., Ferreira, A.B., Barillas-Murry, C. 2017. Molecular mechanisms mediating immune priming in Anopheles gambiae mosquitos. Book Chapter. 91-100. https://doi.org/10.1016/B978-0-12-805350-8.00005-2.
Technical Abstract: The Anopheles gambiae immune priming response is triggered when Plasmodium ookinetes invade the mosquito midgut and the microbiota comes in direct contact with injured cells. This is a long-lasting response that confers the challenged mosquito enhanced ability to control subsequent Plasmodium infections. The immune priming response involves hemocyte differentiation, in particular an increase in the granulocyte population. A hemocyte differentiation factor (HDF) is released into the hemolymph and transfer of cell-free hemolymph from challenged mosquitoes can induce hemocyte differentiation and enhanced immunity in recipient naïve mosquitoes. Biochemical assays and metabololipidomic analysis have uncover that HDF is composed of a Lipocalin/Lipoxin complex and that immune priming involves a persistent increase in the expression of the lipocalin carrier (Evokin), and in the enhanced ability of mosquitoes to convert arachidonic acid to lipoxins.