Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 10/23/2009
Publication Date: N/A
Citation: Interpretive Summary:
Technical Abstract: Avian influenza (AI) remains an economic threat to commercial poultry throughout the world by negatively impacting animal health and trade. Vaccination with high quality efficacious vaccines that are properly delivered can contribute to the control of avian AI outbreaks when used as part of a comprehensive control program that includes enhanced biosecurity, increased surveillance, education, and elimination of infected poultry. Correctly implemented, vaccination can increase the resistance of birds to field challenge and reduce the amount and duration of virus shed in the environment. Critical to the success of a vaccination program to control AI, is monitoring flocks for field virus exposure so appropriate measures can be taken. Most types of vaccination still cause problems with disease protection because it is hard to differentiate infected from vaccinated animals (DIVA). Biotechnological advances may overcome some existing vaccine limitations and result in vaccines that can be grown in tissue culture systems for more rapid vaccine production; provide optimized protection as the result of closer genetic relationship to field viruses; can be mass applied by aerosol, drinking water, or in ovo administration; and provide easier DIVA strategies. In addition, a better understanding of the innate and adaptive immune responses of birds is also likely to improve vaccine adjuvants and provide better vaccine protection.