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Title: In vitro comparison of the cytokine response to avian influenza virus from peripheral blood lymphocyles isolated from chickens differing in Mx631 gene polymorphism

Author
item Kapczynski, Darrell
item EWALD, SANDRA - AUBURN UNIVERSITY
item LIVANT, EMILY - AUBURN UNIVERSITY
item KALTENBOECK, LUDMILLA - AUBURN UNIVERSITY
item Suarez, David

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: 2/14/2009
Publication Date: 7/12/2009
Citation: Kapczynski, D.R., Ewald, S., Livant, E., Kaltenboeck, L., Suarez, D.L. 2009. In vitro comparison of the cytokine response to avian influenza virus from peripheral blood lymphocyles isolated from chickens differing in Mx631 gene polymorphism [abstract]. Abstracts of the 146th American Veterinary Medical Association Annual Convention, July 12-15, 2009, Seattle, Washington. 2009 CDROM.

Interpretive Summary:

Technical Abstract: Following viral infection, the host innate immune response triggers induction of cytokine and interferon genes. Interferon-alpha induction stimulates expression interferon-stimulated genes, including the Mx protein. This protein has been shown to confer protection against influenza in mice. In chickens, a single nucleotide polymorphism (SNP) at position 631(Ser-> Asn) has been determined to enhance protection against avian influenza (AI). In these studies we evaluated the cytokine response in vitro of peripheral blood lymphocytes from chickens with different MX genotypes to AI infection. Preliminary analysis indicates increased cytokine and interferon gene induction in Mx-Asn631 chicken lymphocytes compared to Mx-Ser631 chicken lymphocytes, which may provide insight into the increased AI protection observed in chickens with the MX-631Asn allele.