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ARS Home » Northeast Area » Wyndmoor, Pennsylvania » Eastern Regional Research Center » Residue Chemistry and Predictive Microbiology Research » Research » Publications at this Location » Publication #230146

Title: New Method for Analysis of Multiple Anthelmintic Residues in Animal Tissue

Author
item KINSELLA, BRIAN
item Lehotay, Steven
item Lightfield, Alan
item Mastovska, Katerina
item FUREY, AMBROSE
item DANAHER, MARTIN

Submitted to: Euroresidue Conference Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 3/1/2008
Publication Date: 5/19/2008
Citation: Kinsella, B., Lehotay, S.J., Lightfield, A.R., Mastovska, K., Furey, A., Danaher, M. 2008. New Method for Analysis of Multiple Anthelmintic Residues in Animal Tissue. Euroresidue Conference Proceedings. p.1147-1152.

Interpretive Summary:

Technical Abstract: For the first time, 39 of the major anthelmintics can be detected in one rapid and sensitive LC-MS/MS method, including the flukicides, which have been generally overlooked in surveillance programs. Utilizing the QuEChERS approach, residues were extracted from liver and milk using acetonitrile, sodium chloride, and magnesium sulphate. Extracts were purified by dispersive SPE using magnesium sulphate and octadecylsilane before injection onto the LC-MS/MS. The method was single laboratory validated according to 2002/657/EC criteria. The limit of quantitation of the method was 5 ug/kg for all residues except dichlorvos (10 ug/kg).