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Title: Vaccination as part of an AI control strategy -- currently available tools for emergency vaccination

item Suarez, David

Submitted to: American College of Poultry Veterinarians
Publication Type: Abstract Only
Publication Acceptance Date: 2/15/2007
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Interest in vaccination for avian influenza virus is growing because of the perceived value vaccination has to offer. Vaccination can either be used for disease control or as part of an eradication strategy. Proper vaccination will not only prevent clinical disease, but it will also reduce virus shedding if birds do become infected and it increases the threshold of virus required to infect birds compared to unvaccinated controls. Vaccination as part of an eradication program requires increased surveillance, maintenance of quarantines and animal movement controls, and education to be effective. Improper vaccination can aid in the establishment of endemic infection with periodic disease outbreaks. Vaccines efficacy is associated with the closeness of the vaccine to the field strain, antigen mass, and the adjuvants that are used. High levels of antibody can overcome a poor vaccine match, but to maximally reduce viral shedding high levels of specific antibody needs to be maintained. Currently both killed whole virus adjuvanted vaccines and two recombinant viral vectored vaccines are available for use in some countries. None of the currently available vaccines are amenable to mass vaccination, which limits their use in the field.