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Title: FUNCTIONAL CHARACTERIZATION AND PHYLOGENETIC COMPARISON OF THE CHICKEN TOLL-LIKE RECEPTOR 7

Author
item Kapczynski, Darrell
item PHILBIN, VICTORIA - INST FOR ANML HLTH- UK
item SMITH, ADRIAN - INST FOR ANML HLTH-UK
item Holt, Peter

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: 2/8/2005
Publication Date: 7/17/2005
Citation: Kapczynski, D.R., Philbin, V.J., Smith, A.L., Holt, P.S. 2005. Functional characterization and phylogenetic comparison of the chicken toll-like receptor 7 [abstract]. American Association of Avian Pathologists. p.56.

Interpretive Summary:

Technical Abstract: Abstract: Toll-like receptor (TLR) family members are responsible for recognizing the presence of invading microorganisms through pathogen-associated molecular patterns and initiation of immune responses. Recently, several chicken TLR's have been identified, including TLR7, which is reported to be involved with recognition of ribonucleic acid components characteristic of viral genomes (e.g. ssRNA). In this study, we compared the innate immune response of the avian macrophage cell line, HD11 (TLR7+), to the synthetic TLR7 agonist Loxoribine and live or killed Newcastle disease virus. In addition, the phylogenetic relationship of various TLR7's from avian and mammalian origin will be discussed.