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ARS Home » Research » Publications at this Location » Publication #162258
Title: DEVELOPMENT OF A VIROSOME VACCINE FOR PROTECTING TURKEY POULTS AGAINST SUBTYPE C AVIAN METAPNEUMOVIRUS

Author
item Kapczynski, Darrell

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: 4/2/2004
Publication Date: 7/28/2004
Citation: Kapczynski, D.R. 2004. Development of a virosome vaccine for protecting turkey poults against subtype c avian metapneumovirus. In:Proceedings of the American Association of Avian Pathologists., July 24-28, 2004, Philadelphia, Pennsylvania. 2004 CDROM

Interpretive Summary:

Technical Abstract: An avian metapneumovirus (aMPV) virosome vaccine was prepared and tested for protection of turkeys by aMPV challenge. The vaccine was produced using a detergent-based (Triton X-100) extraction of aMPV subtype C. Western blot and virus-neutralization analysis confirmed that the aMPV virosomes contained both the fusion (F) and attachment (G) glycoproteins. SPF turkeys were immunized either intranasally (IN) or intramuscularly (IM) with the aMPV virosome vaccine. Vaccination decreased clinical signs of disease and viral load in the respiratory tract following virulent challenge. These results demonstrate that immunization of turkeys with aMPV virosomes can be an effective strategy for control of disease.