Submitted to: Cancer Research
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 1/1/2005
Publication Date: 2/1/2005
Citation: Lavigne, J.A., Wimbrow, H.H., Albert, P.S., Reichman, M.E., Campbell, W.S., Barrett, C., Hursting, S.D., Judd, J.T., Taylor, P. 2005. Alcohol, igf-i and igfbp-3 in premenopausal women. Cancer Research.
Interpretive Summary: Both alcohol ingestion and increased concentrations of insulin-like growth factor (IGF-1) have been associated with breast cancer risk. In a study with 31 premenopausal women who drank 0 or 30 mL of alcohol per day (equivalent to approximately 2 drinks) as part of a carefully controlled diet, there was an overall reduction in IFG-1 of 9.5% when alcohol ingestion was compared to control (no alcohol). Decreases occurred in all phases of the menstrual cycle. While we do not know the mechanism by which alcohol affects IGF-1 concentration, future epidemiological studies need to consider both alcohol intake and menstrual cycle phase when evaluating the IGF-1 breast cancer relationship. This study is of interest to epidemiologist and clinical researchers investigating the relationship of diet to cancer risk.
Technical Abstract: Alcohol ingestion and insulin-like growth factor-I [IGF-I] have been associated with breast cancer risk, the latter primarily in menopausal women. We investigated whether alcohol ingestion altered IGF-I or its major binding protein [BP], IGFBP-3, in a controlled feeding study in premenopausal women. Serum was collected from 31 individuals who were randomly assigned to consume either zero or 30 g (two drinks) of alcohol daily for three menstrual cycles and who then crossed over to the other alcohol level for three cycles. All calories were provided and weight was maintained during the study. Alcohol ingestion significantly reduced IGF-I concentrations overall (9.5%, P<0.001), while IGFBP-3 was unaffected. This is the first controlled diet study to show to demonstrate that alcohol decreases serum IGF-I in premenopausal women.