Submitted to: American College of Nutrition
Publication Type: Abstract only
Publication Acceptance Date: 8/23/2003
Publication Date: 10/23/2003
Citation: Behall, K.M., Scholfield, D.J., Hallfrisch, J. 2003. Lipoprotein cholesterol fractions after consumption of whole wheat/rice or barley. American College of Nutrition. 22:476. Interpretive Summary:
Technical Abstract: Barley contains high amounts of soluble fiber but has not been utilized extensively in the US diet. This study investigated whether consumption of barley, consistent with other sources of soluble fiber, would reduce risk factors for cardiovascular disease. After institutional review and approval, moderately hypercholesterolemic subjects (9 post-menopausal women, 9 pre-menopausal women, and 7 men) consumed controlled step one diets for 17 wk. After a 2 wk adaptation period, whole grain foods containing 0, 3, or 6 g soluble fiber/day from barley were included in the step one menus. Subjects consumed these diets for 5 wk each in a Latin square design. Plasma lipid fractions were measured by NMR at the end of each period. Large very low density lipoprotein, large low density lipoprotein (LDL) and small LDL lipoprotein fractions significantly decreased from prestudy and adaptation concentrations with no difference among the three high fiber diets. The mean LDL particle size significantly decreased when whole grains were incorporated into the diet. Large LDL, intermediate high density lipoprotein (HDL) fractions and LDL particle size were significantly higher and small LDL significantly lower in postmenopausal women. No significant difference due to dietary treatment was observed in other lipoprotein fractions. These results indicate that barley may be an effective addition to a healthy diet to lower total and LDL-cholesterol without lowering HDL-cholesterol.