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Miles Lange
Aquatic Animal Health Research
Research Microbiologist

Phone: (334) 887-3741 ext. 132
Fax: (334) 887-2983

990 WIRE RD
AUBURN, AL 36832

(Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)

Projects
Integrated Research to Improve Aquatic Animal Health in Warmwater Aquaculture
In-House Appropriated (D)
  Accession Number: 437658
Assessment of the Immunomodulatory Effect of Probiotics on the Catfish Adaptive Immune Response and Columnaris Disease Resistance
Non-Assistance Cooperative Agreement (S)
  Accession Number: 437857
Developing Sustainable Aquaponic Production Systems
Non-Assistance Cooperative Agreement (S)
  Accession Number: 440661
Effects of Herbicide Exposure on Channel Catfish Biology, Health, and Behavior
Non-Assistance Cooperative Agreement (S)
  Accession Number: 442758

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Genetic variation in disease resistance traits in hybrid striped bass - (Abstract Only)
A recombinant 9E1 monoclonal antibody binds membrane and soluble channel catfish immunoglobulin M Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Churchman, E.M., Wise, A.L., Bruce, T.J. 2023. A recombinant 9E1 monoclonal antibody binds membrane and soluble channel catfish immunoglobulin M. Fish and Shellfish Immunology Reports. 4:100086. https://doi.org/10.1016/j.fsirep.2023.100086.
Whole genome sequencing and annotation of seven strains of aeromonas veronii isolated from channel catfish Reprint Icon - (Peer Reviewed Journal)
Abernathy, J.W., Zhang, D., Liles, M., Lange, M.D., Shoemaker, C.A., Beck, B.H. 2023. Whole genome sequencing and annotation of seven strains of aeromonas veronii isolated from channel catfish. Microbiology Resource Announcements. 12(2):e01231-22. https://doi.org/10.1128/mra.01231-22.
The impact of antimicrobial peptides on the biofilm formation of aquaculture-relevant pathogens - (Abstract Only)
Lange, M.D., Salger, S.A., Reading, B.J., Peatman, E., Beck, B.H. 2023. The impact of antimicrobial peptides on the biofilm formation of aquaculture-relevant pathogens [ABSTRACT]. Aquaculture America Conference. New Orleans, LA, February 23-26, 2023
Transcriptome analysis of Pacific white shrimp (Liptopenaeus vannamei) after exposure to recombinant Vibrio parahaemolyticus PirA and PirB proteins Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Abernathy, J.W., Rawles, A.A., Zhang, D., Shoemaker, C.A., Bader, T.J., Beck, B.H. 2023. Transcriptome analysis of Pacific white shrimp (Liptopenaeus vannamei) after exposure to recombinant Vibrio parahaemolyticus PirA and PirB proteins. Fish and Shellfish Immunology. 132:108502. https://doi.org/10.1016/j.fsi.2022.108502.
Disease resistance in moronid aquaculture - (Abstract Only)
Abernathy, J.W., Lange, M.D., Farmer, B.D., Mcentire, M.E., Rawles, S.D. 2023. Disease resistance in moronid aquaculture [Abstract]. 30th Annual Plant and Animal Genome Conference, San Diego, CA, January 13-18, 2023.
Draft genome sequences of flavobacterium covae strains LSU-066-04 and LV-359-01 Reprint Icon - (Peer Reviewed Journal)
Churchman, E.M., Parello, G., Lange, M.D., Farmer, B.D., Lafrentz, B.R., Beck, B.H., Liles, M.R. 2022. Draft genome sequences of flavobacterium covae strains LSU-066-04 and LV-359-01. Microbiology Resource Announcements. http://doi.org/10.1128/mra.00352-22.
Draft genome sequence of flavobacterium covae strain LV-359-01 - (Database / Dataset)
Churchman, E.M., Parello, G., Lange, M.D., Farmer, B.D., Lafrentz, B.R., Beck, B.H., Liles, M.R. 2022. Draft genome sequence of flavobacterium covae strain LV-359-01. National Center for Biotechnology Information (NCBI). SAMN26856627.
Draft genome sequence of flavobacterium covae strain LSU-066-04 - (Database / Dataset)
Churchman, E.M., Parello, G., Lange, M.D., Farmer, B.D., Lafrentz, B.R., Beck, B.H., Liles, M.R. 2022. Draft genome sequence of flavobacterium covae strain LSU-066-04. National Center for Biotechnology Information (NCBI). SAMN26856626.
Shrimp transcriptome analysis after exposure to recombinant Vibrio parahaemolyticus PirA and PirB toxins - (Database / Dataset)
Rawles, A.A., Abernathy, J.W., Lange, M.D., Shoemaker, C.A., Zhang, D., Bader, T.J., Beck, B.H. 2022. Shrimp transcriptome analysis after exposure to recombinant Vibrio parahaemolyticus PirA and PirB toxins. National Center for Biotechnology Information (NCBI).
Identification and characterization of differentially expressed channel catfish IgM transcripts after vaccination with antigens of virulent aeromonas hydrophila Reprint Icon - (Peer Reviewed Journal)
Zhang, D., Lange, M.D., Shoemaker, C.A., Beck, B.H. 2022. Identification and characterization of differentially expressed channel catfish IgM transcripts after vaccination with antigens of virulent aeromonas hydrophila. Fishes. 2022(7):24. https://doi.org/10.3390/fishes7010024.
Use of a Flavobacterium columnare DnaK recombinant protein vaccine to guard against columnaris disease in channel catfish - (Abstract Only)
Lange, M.D. 2021. Use of a Flavobacterium columnare DnaK recombinant protein vaccine to guard against columnaris disease in channel catfish. Proceedings of US-Japan Natural Resources Panel on Aquaculture [abstract]. 13-14.
Analysis of variation of immunoglobulin (Ig) M transcripts in channel catfish vaccinated with extracellular proteins of virulent Aeromonas hydrophila - (Database / Dataset)
Zhang, D., Lange, M.D., Shoemaker, C.A., Beck, B.H. 2022. Analysis of variation of immunoglobulin (Ig) M transcripts in channel catfish vaccinated with extracellular proteins of virulent Aeromonas hydrophila. National Center for Biotechnology Information (NCBI).
The effect of piscidin antimicrobial peptides on the formation of Gram-negative bacterial biofilms Reprint Icon - (Peer Reviewed Journal)
Prior, B.S., Lange, M.D., Salger, S.A., Reading, B.J., Peatman, E., Beck, B.H. 2022. The effect of piscidin antimicrobial peptides on the formation of Gram-negative bacterial biofilms. Journal of Fish Diseases. 45(1):99-105. https://doi.org/10.1111/jfd.13540.
Use of an immersion adjuvant with a Flavobacterium columnare recombinant protein vaccine in channel catfish Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Abernathy, J.W., Farmer, B.D., Beck, B.H. 2021. Use of an immersion adjuvant with a Flavobacterium columnare recombinant protein vaccine in channel catfish. Fish and Shellfish Immunology. 117:136-139. https://doi.org/10.1016/j.fsi.2021.07.025.
Impact of dietary phytase on tilapia performance and biofloc water quality Reprint Icon - (Peer Reviewed Journal)
Green, B.W., Rawles, S.D., Schrader, K., Mcentire, M.E., Abernathy, J.W., Ray, C.L., Gaylord, T.G., Lange, M.D., Webster, C.D. 2021. Impact of dietary phytase on tilapia performance and biofloc water quality. Aquaculture. 541:1-11. https://doi.org/10.1016/j.aquaculture.2021.736845.
Bioeconomics of Flavobacterium columnare vaccine pond trials with channel catfish Ictalurus punctatus Reprint Icon - (Peer Reviewed Journal)
Malecki, J.K., Roy, L., Arias, C.R., Lange, M.D., Beck, B.H., Truong, N., Hanson, T.R. 2021. Bioeconomics of Flavobacterium columnare vaccine pond trials with channel catfish Ictalurus punctatus. North American Journal of Aquaculture. 83: 207-217. https://doi.org/10.1002/naaq.10191.
Bioeconomics of Flavobacterium columnare Vaccine Pond Trials with Channel Catfish Ictalurus punctatus Reprint Icon - (Peer Reviewed Journal)
Malecki, J.K., Roy, L.A., Arias, C.R., Lange, M.D., Shoemaker, C.A., Beck, B.H., Truong, N.T., Hanson, T.R. 2021. Bioeconomics of Flavobacterium columnare Vaccine Pond Trials with Channel Catfish Ictalurus punctatus. North American Journal of Aquaculture. https://doi.org/10.1002/naaq.10191.
Toxicity of recombinant PirA and PirB derived from Vibrio parahaemolyticus in shrimp Reprint Icon - (Peer Reviewed Journal)
Zhang, D., Bader, T.J., Lange, M.D., Shoemaker, C.A., Beck, B.H. 2021. Toxicity of recombinant PirA and PirB derived from Vibrio parahaemolyticus in shrimp. Microbial Pathogenesis. 155:104886. https://doi.org/10.1016/j.micpath.2021.104886.
Proteome analysis of virulent Aeromonas hydrophila reveals the upregulation of iron acquisition systems in the presence of a xenosiderophore Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Abernathy, J.W., Shoemaker, C.A., Zhang, D., Kirby, A., Peatman, E., Beck, B.H. 2020. Proteome analysis of virulent Aeromonas hydrophila reveals the upregulation of iron acquisition systems in the presence of a xenosiderophore. FEMS Microbiology Letters. 367(20):1-8. https://doi.org/10.1093/femsle/fnaa169.
Differential susceptibility of white bass (Morone chrysops), striped bass (Morone saxatilis) and hybrid striped bass (M. chrysops x M. saxatilis) to Flavobacterium columnare and effects of mucus on bacterial growth and bio Reprint Icon - (Peer Reviewed Journal)
Farmer, B.D., Fuller, S.A., Beck, B.H., Abernathy, J.W., Lange, M.D., Webster, C.D. 2020. Differential susceptibility of white bass (Morone chrysops), striped bass (Morone saxatilis) and hybrid striped bass (M. chrysops x M. saxatilis) to Flavobacterium columnare and effects of mucus on bacterial growth and bio. Journal of Fish Diseases. 44(2):161-169. https://doi.org/10.1111/jfd.13272.
Aeromonas hydrophila stimulated with deferoxamine mesylate LC-MSMS - (Database / Dataset)
Fish health research updates for 2019 - (Popular Publication)
Beck, B.H., Shoemaker, C.A., Aksoy, M., Zhang, D., Bader, T.J., Peatman, E., Lange, M.D., Fuller, S.A., Liles, M. 2019. Fish health research updates for 2019. Fish Farming News. 2019(2):9-10.
Vertebrate mucus stimulates biofilm development and upregulates iron acquisition genes in Flavobacterium columnare Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Farmer, B.D., Abernathy, J.W. 2019. Vertebrate mucus stimulates biofilm development and upregulates iron acquisition genes in Flavobacterium columnare. Journal of Fish Diseases. https://doi.org/10.1111/jfd.13103.
Alternative gene splicing in catfish after treatment with copper sulfate and exposure to Flavobacterium columnare - (Database / Dataset)
Gene expression profiling of catfish after treatment with copper sulfate and exposure to Flavobacterium columnare - (Database / Dataset)
Evaluation of Flavobacterium columnare DnaK recombinant protein vaccine as a means of protection against columnaris disease in channel catfish, Ictalurus punctatus Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Abernathy, J.W., Farmer, B.D. 2019. Evaluation of Flavobacterium columnare DnaK recombinant protein vaccine as a means of protection against columnaris disease in channel catfish, Ictalurus punctatus. Frontiers in Immunology. p. 1-13. https://doi.org/10.3389/fimmu.2019.01175.
Evidence that the stress hormone cortisol regulates biofilm formation differently among Flavobacterium columnare isolates Reprint Icon - (Peer Reviewed Journal)
Declercq, A., Cai, C., Naranjo, W., Thongda, W., Eeckhaut, V., Bauwens, E., Arias, C., De La Fuente, L., Beck, B.H., Lange, M.D., Peatman, E., Aerts, J., Haesebrouck, F., Decostere, A. 2019. Evidence that the stress hormone cortisol regulates biofilm formation differently among Flavobacterium columnare isolates. Veterinary Research. 50(1):24. https://doi.org/10.1186/s13567-019-0641-3.
Catfish mucus changes the Flavobacterium columnare transcriptome - (Abstract Only)
Lange, M.D., Abernathy, J.W., Farmer, B.D. 2019. Catfish mucus changes the Flavobacterium columnare transcriptome [abstract]. Aquaculture 2019, March 7-11, 2019, New Orleans, Louisana. p. 602.
Fish and porcine mucus stimulate F. columnare biofilm formation - (Abstract Only)
Farmer, B.D., Lange, M.D., Abernathy, J.W. 2019. Fish and porcine mucus stimulate F. columnare biofilm formation [abstract]. Aquaculture 2019, March 7-11, 2019, New Orleans, Louisana. p. 349.
The proliferation and clonal migration of B cells in the systemic and mucosal tissues of channel catfish suggests there is an interconnected mucosal immune system Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Waldbieser, G.C., Lobb, C.J. 2019. The proliferation and clonal migration of B cells in the systemic and mucosal tissues of channel catfish suggests there is an interconnected mucosal immune system. Fish and Shellfish Immunology. 84:1134-1144. https://doi.org/10.1016/j.fsi.2018.11.014.
Novel protein-based therapy for the managing disease that stimulates catfish antimicrobial immunity and tissue repair system - (Abstract Only)
Dolan, M.C., Elkins, L., Lange, M.D., Abernathy, J.W. 2018. Novel protein-based therapy for the managing disease that stimulates catfish antimicrobial immunity and tissue repair system [abstract]. 99th Conference of Research Workers in Animal Diseases, December 2-4, 2018, Chicago, Illinois. PO52.
Gene expression profiling of catfish after treatment with Flavobacterium columnare DnaK protein - (Database / Dataset)
Abernathy, J.W., Lange, M.D. 2019. Gene expression profiling of catfish after treatment with Flavobacterium columnare DnaK protein. Genbank Accession No. GSE121116.
Stress hormone cortisol helps to drive biofilm formation in Flavobacterium columnare - (Abstract Only)
Declercq, A., Cai, W., Naranjo, E., Thongda, W., Eckhaut, V., Bauwens, E., Arias, C., De La Fuente, L., Beck, B.H., Lange, M.D., Peatman, E., Haesebrougk, F., Aerts, J., Decostere, A. 2018. Stress hormone cortisol helps to drive biofilm formation in Flavobacterium columnare [abstract]. 5th International Conference of Members of the Genus Flavobacterium 2018. p. 42.
Fish mucus alters the Flavobacterium columnare biofilm transcriptome - (Abstract Only)
Lange, M.D., Farmer, B.D., Abernathy, J.W. 2018. Fish mucus alters the Flavobacterium columnare biofilm transcriptome [abstract]. Meeting Abstract, 5th International Conference on members of the genus Flavobacterium, November 27-29, 2018, Nara, Japan. p. 41.
Catfish mucus alters the Flavobacterium columnare transcriptome Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Abernathy, J.W., Farmer, B.D. 2018. Catfish mucus alters the Flavobacterium columnare transcriptome. FEMS Microbiology Letters. 365(22)1-13. https://doi.org/10.1093/femsle/fny244.
B cell clonal lineage alterations upon recombinant HIV-1 envelope immunization of Rhesus macaques Reprint Icon - (Peer Reviewed Journal)
Yacoob, C., Lange, M.D., Cohen, K., Lathia, K., Feng, J., Glenn, J., Carbonetti, S., Oliver, B., Vigdorovich, V., Sather, D., Stamatatos, L. 2018. B cell clonal lineage alterations upon recombinant HIV-1 envelope immunization of Rhesus macaques. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1007120.
Fish mucus alters the Flavobacterium columnare transcriptome - (Abstract Only)
Lange, M.D., Farmer, B.D., Abernathy, J.W. 2018. Fish mucus alters the Flavobacterium columnare transcriptome [abstract]. Meeting Abstract, 4th Annual Meeting of the Arkansas Bioinformatics Consortium AR-BIC 2018,April 23-24th, 2018, Little Rock, ARkansas. p. 56.
Coordinated effort to advance genomes-to-phenomes through the integration of bioinformatics with aquaculture research - (Abstract Only)
Abernathy, J.W., Fuller, S.A., Green, B.W., Lange, M.D., Rawles, S.D., Straus, D.L., Webster, C.D. 2018. Coordinated effort to advance genomes-to-phenomes through the integration of bioinformatics with aquaculture research [abstract]. Meeting Abstract, 4th Annual Meeting of the Arkansas Bioinformatics Consortium AR-BIC 2018, April 23-24th, 2018, Little Rock, Arkansas. p. 45.
Gene expression analysis between planktonic and biofilm states of Flavobacterium columnare - (Database / Dataset)
Abernathy, J.W., Lange, M.D. 2018. Gene expression analysis between planktonic and biofilm states of Flavobacterium columnare. Genbank. Accession # GSE109937.
Production of stocker-size hybrid tilapia in an outdoor biofloc production system - (Abstract Only)
Green, B.W., Rawles, S.D., McEntire, M.E., Ray, C.L., Lange, M.D., Farmer, B.D. 2018. Production of stocker-size hybrid tilapia in an outdoor biofloc production system [abstract]. Aquaculture America Conference, February 19-22, 2018, Las Vegas, Neveda. p. 383.
The effect of temperature on the mucosal IgM antibody response to DNP-KLH in channel catfish (Ictalurus punctatus) Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Webster, C.D. 2017. The effect of temperature on the mucosal IgM antibody response to DNP-KLH in channel catfish (Ictalurus punctatus). Fish and Shellfish Immunology. 70:493-497.
The stress hormone cortisol: a (co)regulator of biofilm formation in Flavobacterum columnare? - (Abstract Only)
Declercq, A.M., Cai, W., Naranjo, E., Thongda, W., Arias, C., De La Fuente, L., Beck, B.H., Lange, M.D., Peatman, E., Aerts, J., Decostere, A.M. 2017. The stress hormone cortisol: a (co)regulator of biofilm formation in Flavobacterum columnare? [abstract]. International Conference on Diseases of Fish and Shellfish. p. 18.
Sickeningly sweet: L-rhamnose stimulates Flavobacterium columnare biofilm formation and virulence Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Farmer, B.D., Declercq, A.M., Peatman, E., Decostere, A., Beck, B.H. 2017. Sickeningly sweet: L-rhamnose stimulates Flavobacterium columnare biofilm formation and virulence. Journal of Fish Diseases. doi:10.1111/jfd.12629.
The carbohydrate L-rhamnose promotes biofilm formation which enhances Flavobacterium columnare virulence - (Abstract Only)
Lange, M.D., Farmer, B.D., Brown, J.D., Barnett, L.M., Peatman, E., Beck, B.H. 2017. The carbohydrate L-rhamnose promotes biofilm formation which enhances Flavobacterium columnare virulence [abstract]. Aquaculture America. p. 1.
Impact of oral and waterborne administration of rhamnolipids on the susceptibility of channel catfish (Ictalurus punctatus) to Flavobacterium columnare infection - (Peer Reviewed Journal)
Zhang, D., Beck, B.H., Lange, M.D., Zhao, H., Thongda, W., Ye, Z., Li, C., Peatman, E. 2016. Impact of oral and waterborne administration of rhamnolipids on the susceptibility of channel catfish (Ictalurus punctatus) to Flavobacterium columnare infection. Fish and Shellfish Immunology. 60:44-49.
Repertoire comparison of the B-cell receptor encoding loci in humans and rhesus macaques by next generation sequencing - (Peer Reviewed Journal)
Vigdorovich, V., Oliver, B.G., Carbonetti, S., Dambrauskas, N., Lange, M.D., Yacoob, C., Leahy, W., Callahan, J., Stamatatos, L., Sather, D. 2016. Repertoire comparison of the B-cell receptor encoding loci in humans and rhesus macaques by next generation sequencing. Clinical and Translational Immunology. 5.
Missing the target: DNAk is a dominant epitope in the humoral immune response of channel catfish (Ictalurus punctatus) to Flavobacterium columnare - (Abstract Only)
Lange, M.D., Beck, B.H., Brown, J.D., Farmer, B.D., Barnett, L.M., Webster, C.D. 2016. Missing the target: DNAk is a dominant epitope in the humoral immune response of channel catfish (Ictalurus punctatus) to Flavobacterium columnare [abstract]. Fish and Shellfish Immunology. p. 1.
Missing the target: DNAk is a dominant epitope in the humoral immune response of channel catfish (Ictalurus punctatus) to Flavobacterium columnare Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Beck, B.H., Brown, J.D., Farmer, B.D., Barnett, L.M., Webster, C.D. 2016. Missing the target: DNAk is a dominant epitope in the humoral immune response of channel catfish (Ictalurus punctatus) to Flavobacterium columnare. Fish and Shellfish Immunology. 51:170-179.
Beta-conglycinin and gut histology of sunshine bass fed diets with new varieties of non-GM soybeans - (Abstract Only)
Ramena, Y., Lange, M.D., Rawles, S.D., Lochmann, R., Chen, P., Gaylord, T., Mcentire, M.E., Beck, B.H., Farmer, B.D., Barrows, F. 2016. B-conglycinin and gut histology of sunshine bass fed diets with new varieties of non-gm soybeans. [abstract]. Aquaculture America Conference. p. 654.
Evaluation of growth, nutrient retention, health, and resistance to bacterial challenge in sunshine bass fed diets with new varieties of non-genetically modified soybeans - (Abstract Only)
Ramena, Y., Rawles, S.D., Lochmann, R., Chen, P., Gaylord, T., Mcentire, M.E., Beck, B.H., Farmer, B.D., Lange, M.D., Barrows, F. 2016. Evaluation of growth, nutrient retention, health, and resistance to bacterial challenge in sunshine bass fed diets with new varieties of non-genetically modified soybeans. [abstract]. Aquaculture America Conference. P. 653.
Evaluation of the antibody response to the LV-359-01 strain of flavobacterium columnare - (Abstract Only)
Lange, M.D., Brown, J.D., Farmer, B.D., Beck, B.H. 2015. Evaluation of the antibody response to the LV-359-01 strain of flavobacterium columnare [abstract]. 4th International conference on Members of the genus Flavobacterium, Auburn, Alabama. p. 70.
Physiology and immunology of mucosal barriers in catfish (Ictalurus spp.) - (Peer Reviewed Journal)
Peatman, E., Lange, M.D., Zhao, H., Beck, B.H. 2015. Physiology and immunology of mucosal barriers in catfish (Ictalurus spp.). Tissue Barriers. DOI: 10.1080/21688370.2015.1068907.
A comparison of high and low virulence Flavobacterium columnare strains reveals differences in iron acquisition components and responses to iron restriction - (Peer Reviewed Journal)
Beck, B.H., Li, C., Farmer, B.D., Barnett, L.M., Lange, M.D., Peatman, E. 2015. A comparison of high and low virulence Flavobacterium columnare strains reveals differences in iron acquisition components and responses to iron restriction. Journal of Fish Diseases. DOI: 10.1111/jfd.12343.