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Miles Lange
Aquatic Animal Health Research
Research Microbiologist

Phone: (334) 887-3741 ext. 132
Fax: (334) 887-2983

990 WIRE RD
AUBURN, AL 36832
Projects
Integrated Research to Improve Aquatic Animal Health in Warmwater Aquaculture
In-House Appropriated (D)
  Accession Number: 437658
Assessment of the Immunomodulatory Effect of Probiotics on the Catfish Adaptive Immune Response and Columnaris Disease Resistance
Non-Assistance Cooperative Agreement (S)
  Accession Number: 437857

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Aeromonas hydrophila stimulated with deferoxamine mesylate LC-MSMS ()
Vertebrate mucus stimulates biofilm development and upregulates iron acquisition genes in Flavobacterium columnare Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Farmer, B.D., Abernathy, J.W. 2019. Vertebrate mucus stimulates biofilm development and upregulates iron acquisition genes in Flavobacterium columnare. Journal of Fish Diseases. https://doi.org/10.1111/jfd.13103.
Alternative gene splicing in catfish after treatment with copper sulfate and exposure to Flavobacterium columnare ()
Gene expression profiling of catfish after treatment with copper sulfate and exposure to Flavobacterium columnare ()
Evaluation of Flavobacterium columnare DnaK recombinant protein vaccine as a means of protection against columnaris disease in channel catfish, Ictalurus punctatus Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Abernathy, J.W., Farmer, B.D. 2019. Evaluation of Flavobacterium columnare DnaK recombinant protein vaccine as a means of protection against columnaris disease in channel catfish, Ictalurus punctatus. Frontiers in Immunology. p. 1-13. https://doi.org/10.3389/fimmu.2019.01175.
Evidence that the stress hormone cortisol regulates biofilm formation differently among Flavobacterium columnare isolates Reprint Icon - (Peer Reviewed Journal)
Declercq, A., Cai, C., Naranjo, W., Thongda, W., Eeckhaut, V., Bauwens, E., Arias, C., De La Fuente, L., Beck, B.H., Lange, M.D., Peatman, E., Aerts, J., Haesebrouck, F., Decostere, A. 2019. Evidence that the stress hormone cortisol regulates biofilm formation differently among Flavobacterium columnare isolates. Veterinary Research. 50(1):24. https://doi.org/10.1186/s13567-019-0641-3.
Catfish mucus changes the Flavobacterium columnare transcriptome - (Abstract Only)
Lange, M.D., Abernathy, J.W., Farmer, B.D. 2019. Catfish mucus changes the Flavobacterium columnare transcriptome [abstract]. Aquaculture 2019, March 7-11, 2019, New Orleans, Louisana. p. 602.
Fish and porcine mucus stimulate F. columnare biofilm formation - (Abstract Only)
Farmer, B.D., Lange, M.D., Abernathy, J.W. 2019. Fish and porcine mucus stimulate F. columnare biofilm formation [abstract]. Aquaculture 2019, March 7-11, 2019, New Orleans, Louisana. p. 349.
The proliferation and clonal migration of B cells in the systemic and mucosal tissues of channel catfish suggests there is an interconnected mucosal immune system Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Waldbieser, G.C., Lobb, C.J. 2019. The proliferation and clonal migration of B cells in the systemic and mucosal tissues of channel catfish suggests there is an interconnected mucosal immune system. Fish and Shellfish Immunology. 84:1134-1144. https://doi.org/10.1016/j.fsi.2018.11.014.
Novel protein-based therapy for the managing disease that stimulates catfish antimicrobial immunity and tissue repair system - (Abstract Only)
Dolan, M.C., Elkins, L., Lange, M.D., Abernathy, J.W. 2018. Novel protein-based therapy for the managing disease that stimulates catfish antimicrobial immunity and tissue repair system [abstract]. 99th Conference of Research Workers in Animal Diseases, December 2-4, 2018, Chicago, Illinois. PO52.
Gene expression profiling of catfish after treatment with Flavobacterium columnare DnaK protein ()
Abernathy, J.W., Lange, M.D. 2019. Gene expression profiling of catfish after treatment with Flavobacterium columnare DnaK protein. Genbank Accession No. GSE121116.
Stress hormone cortisol helps to drive biofilm formation in Flavobacterium columnare - (Abstract Only)
Declercq, A., Cai, W., Naranjo, E., Thongda, W., Eckhaut, V., Bauwens, E., Arias, C., De La Fuente, L., Beck, B.H., Lange, M.D., Peatman, E., Haesebrougk, F., Aerts, J., Decostere, A. 2018. Stress hormone cortisol helps to drive biofilm formation in Flavobacterium columnare [abstract]. 5th International Conference of Members of the Genus Flavobacterium 2018. p. 42.
Fish mucus alters the Flavobacterium columnare biofilm transcriptome - (Abstract Only)
Lange, M.D., Farmer, B.D., Abernathy, J.W. 2018. Fish mucus alters the Flavobacterium columnare biofilm transcriptome [abstract]. Meeting Abstract, 5th International Conference on members of the genus Flavobacterium, November 27-29, 2018, Nara, Japan. p. 41.
Catfish mucus alters the Flavobacterium columnare transcriptome Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Abernathy, J.W., Farmer, B.D. 2018. Catfish mucus alters the Flavobacterium columnare transcriptome. FEMS Microbiology Letters. 365(22)1-13. https://doi.org/10.1093/femsle/fny244.
B cell clonal lineage alterations upon recombinant HIV-1 envelope immunization of Rhesus macaques Reprint Icon - (Peer Reviewed Journal)
Yacoob, C., Lange, M.D., Cohen, K., Lathia, K., Feng, J., Glenn, J., Carbonetti, S., Oliver, B., Vigdorovich, V., Sather, D., Stamatatos, L. 2018. B cell clonal lineage alterations upon recombinant HIV-1 envelope immunization of Rhesus macaques. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1007120.
Fish mucus alters the Flavobacterium columnare transcriptome - (Abstract Only)
Lange, M.D., Farmer, B.D., Abernathy, J.W. 2018. Fish mucus alters the Flavobacterium columnare transcriptome [abstract]. Meeting Abstract, 4th Annual Meeting of the Arkansas Bioinformatics Consortium AR-BIC 2018,April 23-24th, 2018, Little Rock, ARkansas. p. 56.
Coordinated effort to advance genomes-to-phenomes through the integration of bioinformatics with aquaculture research - (Abstract Only)
Abernathy, J.W., Fuller, S.A., Green, B.W., Lange, M.D., Rawles, S.D., Straus, D.L., Webster, C.D. 2018. Coordinated effort to advance genomes-to-phenomes through the integration of bioinformatics with aquaculture research [abstract]. Meeting Abstract, 4th Annual Meeting of the Arkansas Bioinformatics Consortium AR-BIC 2018, April 23-24th, 2018, Little Rock, Arkansas. p. 45.
Gene expression analysis between planktonic and biofilm states of Flavobacterium columnare ()
Abernathy, J.W., Lange, M.D. 2018. Gene expression analysis between planktonic and biofilm states of Flavobacterium columnare. Genbank. Accession # GSE109937.
Production of stocker-size hybrid tilapia in an outdoor biofloc production system - (Abstract Only)
Green, B.W., Rawles, S.D., McEntire, M.E., Ray, C.L., Lange, M.D., Farmer, B.D. 2018. Production of stocker-size hybrid tilapia in an outdoor biofloc production system [abstract]. Aquaculture America Conference, February 19-22, 2018, Las Vegas, Neveda. p. 383.
The effect of temperature on the mucosal IgM antibody response to DNP-KLH in channel catfish (Ictalurus punctatus) Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Webster, C.D. 2017. The effect of temperature on the mucosal IgM antibody response to DNP-KLH in channel catfish (Ictalurus punctatus). Fish and Shellfish Immunology. 70:493-497.
The stress hormone cortisol: a (co)regulator of biofilm formation in Flavobacterum columnare? - (Abstract Only)
Declercq, A.M., Cai, W., Naranjo, E., Thongda, W., Arias, C., De La Fuente, L., Beck, B.H., Lange, M.D., Peatman, E., Aerts, J., Decostere, A.M. 2017. The stress hormone cortisol: a (co)regulator of biofilm formation in Flavobacterum columnare? [abstract]. International Conference on Diseases of Fish and Shellfish. p. 18.
Sickeningly sweet: L-rhamnose stimulates Flavobacterium columnare biofilm formation and virulence Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Farmer, B.D., Declercq, A.M., Peatman, E., Decostere, A., Beck, B.H. 2017. Sickeningly sweet: L-rhamnose stimulates Flavobacterium columnare biofilm formation and virulence. Journal of Fish Diseases. doi:10.1111/jfd.12629.
The carbohydrate L-rhamnose promotes biofilm formation which enhances Flavobacterium columnare virulence - (Abstract Only)
Lange, M.D., Farmer, B.D., Brown, J.D., Barnett, L.M., Peatman, E., Beck, B.H. 2017. The carbohydrate L-rhamnose promotes biofilm formation which enhances Flavobacterium columnare virulence [abstract]. Aquaculture America. p. 1.
Impact of oral and waterborne administration of rhamnolipids on the susceptibility of channel catfish (Ictalurus punctatus) to Flavobacterium columnare infection - (Peer Reviewed Journal)
Zhang, D., Beck, B.H., Lange, M.D., Zhao, H., Thongda, W., Ye, Z., Li, C., Peatman, E. 2016. Impact of oral and waterborne administration of rhamnolipids on the susceptibility of channel catfish (Ictalurus punctatus) to Flavobacterium columnare infection. Fish and Shellfish Immunology. 60:44-49.
Repertoire comparison of the B-cell receptor encoding loci in humans and rhesus macaques by next generation sequencing - (Peer Reviewed Journal)
Vigdorovich, V., Oliver, B.G., Carbonetti, S., Dambrauskas, N., Lange, M.D., Yacoob, C., Leahy, W., Callahan, J., Stamatatos, L., Sather, D. 2016. Repertoire comparison of the B-cell receptor encoding loci in humans and rhesus macaques by next generation sequencing. Clinical and Translational Immunology. 5.
Missing the target: DNAk is a dominant epitope in the humoral immune response of channel catfish (Ictalurus punctatus) to Flavobacterium columnare - (Abstract Only)
Lange, M.D., Beck, B.H., Brown, J.D., Farmer, B.D., Barnett, L.M., Webster, C.D. 2016. Missing the target: DNAk is a dominant epitope in the humoral immune response of channel catfish (Ictalurus punctatus) to Flavobacterium columnare [abstract]. Fish and Shellfish Immunology. p. 1.
Missing the target: DNAk is a dominant epitope in the humoral immune response of channel catfish (Ictalurus punctatus) to Flavobacterium columnare Reprint Icon - (Peer Reviewed Journal)
Lange, M.D., Beck, B.H., Brown, J.D., Farmer, B.D., Barnett, L.M., Webster, C.D. 2016. Missing the target: DNAk is a dominant epitope in the humoral immune response of channel catfish (Ictalurus punctatus) to Flavobacterium columnare. Fish and Shellfish Immunology. 51:170-179.
Beta-conglycinin and gut histology of sunshine bass fed diets with new varieties of non-GM soybeans - (Abstract Only)
Ramena, Y., Lange, M.D., Rawles, S.D., Lochmann, R., Chen, P., Gaylord, T., Mcentire, M.E., Beck, B.H., Farmer, B.D., Barrows, F. 2016. B-conglycinin and gut histology of sunshine bass fed diets with new varieties of non-gm soybeans. [abstract]. Aquaculture America Conference. p. 654.
Evaluation of growth, nutrient retention, health, and resistance to bacterial challenge in sunshine bass fed diets with new varieties of non-genetically modified soybeans - (Abstract Only)
Ramena, Y., Rawles, S.D., Lochmann, R., Chen, P., Gaylord, T., Mcentire, M.E., Beck, B.H., Farmer, B.D., Lange, M.D., Barrows, F. 2016. Evaluation of growth, nutrient retention, health, and resistance to bacterial challenge in sunshine bass fed diets with new varieties of non-genetically modified soybeans. [abstract]. Aquaculture America Conference. P. 653.
Evaluation of the antibody response to the LV-359-01 strain of flavobacterium columnare - (Abstract Only)
Lange, M.D., Brown, J.D., Farmer, B.D., Beck, B.H. 2015. Evaluation of the antibody response to the LV-359-01 strain of flavobacterium columnare [abstract]. 4th International conference on Members of the genus Flavobacterium, Auburn, Alabama. p. 70.
Physiology and immunology of mucosal barriers in catfish (Ictalurus spp.) - (Peer Reviewed Journal)
Peatman, E., Lange, M.D., Zhao, H., Beck, B.H. 2015. Physiology and immunology of mucosal barriers in catfish (Ictalurus spp.). Tissue Barriers. DOI: 10.1080/21688370.2015.1068907.
A comparison of high and low virulence Flavobacterium columnare strains reveals differences in iron acquisition components and responses to iron restriction - (Peer Reviewed Journal)
Beck, B.H., Li, C., Farmer, B.D., Barnett, L.M., Lange, M.D., Peatman, E. 2015. A comparison of high and low virulence Flavobacterium columnare strains reveals differences in iron acquisition components and responses to iron restriction. Journal of Fish Diseases. DOI: 10.1111/jfd.12343.