Location: Aquatic Animal Health Research
Title: Analysis of variation of immunoglobulin (Ig) M transcripts in channel catfish vaccinated with extracellular proteins of virulent Aeromonas hydrophilaAuthor
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Zhang, Dunhua |
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Lange, Miles |
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Shoemaker, Craig |
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Beck, Benjamin |
Submitted to: National Center for Biotechnology Information (NCBI)
Publication Type: Database / Dataset Publication Acceptance Date: 10/11/2021 Publication Date: 3/2/2022 Citation: Zhang, D., Lange, M.D., Shoemaker, C.A., Beck, B.H. 2022. Analysis of variation of immunoglobulin (Ig) M transcripts in channel catfish vaccinated with extracellular proteins of virulent Aeromonas hydrophila. National Center for Biotechnology Information (NCBI). Interpretive Summary: Technical Abstract: Immunoglobulin (Ig) M is the major antibodies produced in Channel catfish (Ictalurus punctatus) against invading pathogens/antigens. Vaccination of the fish with extracellular proteins (ECP) of virulent Aeromonas hydrophila (vAh, a severe disease-causing bacterial pathogens) protected fish against the establishment of pathogenesis. IgM transcripts (cDNA) from vaccinated/disease resistant fish were cloned and sequenced. Sequence data revealed differential expression of IgM isotypes (variants) between vaccinated fish and unvaccinated control fish. Vaccinated fish produced specific IgM transcripts in response to vAh immunogens. Characterized sequences of these IgM isotypes were deposited in the National Center for Biotechnology Information (NCBI) database under GenBank accession numbers: MZ803140 - MZ803182, MZ773892, and MZ773893. |