Randy Sacco : USDA ARS

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Randy E Sacco
Ruminant Diseases and Immunology Research
Microbiologist

Phone: (515) 337-7354
Fax: (515) 337-7149
Room 1131

1920 DAYTON AVE
AMES , IA 50010

Projects

Development of Atlantic Bottlenose Dolphin Cytokine Assays

	Cooperative Agreement (A)
	Accession Number: 434484

Identification of Disease Mechanisms and Control Strategies for Bacterial Respiratory Pathogens in Ruminants

	In-House Appropriated (D)
	Accession Number: 432020

Identification of Disease Mechanisms and Control Strategies for Viral Respiratory Pathogens of Ruminants

	In-House Appropriated (D)
	Accession Number: 432021

Development of Atlantic Bottlenose Dolphin Cytokine Assays

	Interagency Reimbursable Agreement (I)
	Accession Number: 434002

A Novel Approach to RSV Vaccination

	Reimbursable Cooperative Agreement (R)
	Accession Number: 427517

Publications (Clicking on the reprint icon

will take you to the publication reprint.)

Immunomediator expression profiling in two beluga whale (delphinapterus leucas) clinical cases -

Identification of a DRB3*1101-restricted CD4 T cell response against bovine respiratory syncytial virus -

Efficacy of mucosal polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf -

McGill, J.L., Kelly, S.M., Kumar, P., Speckhart, S., Haughney, S.L., Henningson, J., Narasimhan, B., Sacco, R.E. 2018. Efficacy of mucosal polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf. Scientific Reports. 8:3021. https://doi.org/10.1038/s41598-018-21292-2.

Development and testing of species-specific ELISA assays to measure IFN-gamma and TNF-alpha in bottlenose dolphins (Tursiops truncatus) -

Eberle, K.C., Venn-Watson, S.K., Jensen, E.D., Labresh, J., Sullivan, Y., Kakach, L., Sacco, R.E. 2018. Development and testing of species-specific ELISA assays to measure IFN-gamma and TNF-alpha in bottlenose dolphins (Tursiops truncatus). PLoS One. 13(1):e0190786. https://doi.org/10.1371/journal.pone.0190786.

Longitudinal monitoring of bottlenose dolphins leukocyte cytokine mRNA responsiveness by qPCR -

Efficacy of a mucosal, polyanhydride nanovaccine for use against respiratory syncytial virus infection in the neonatal calf -

McGill, J.L., Kelly, S.M., Kumar, P., Speckhart, S., Haughney, S.L., Henningson, J., Narasimhan, B., Sacco, R.E. 2018. Efficacy of mucosal, polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf. Nature Scientific Reports. 8(1):3021. https://doi.org/10.1038/s41598-018-21292-2.

Genomic and transcriptomic analysis of Escherichia coli strains associated with persistent and transient bovine mastitis and the role of colanic acid -

Lippolis, J.D., Holman, D.B., Brunelle, B.W., Thacker, T.C., Bearson, B.L., Reinhardt, T.A., Sacco, R.E., Casey, T. 2017. Genomic and transcriptomic analysis of Escherichia coli strains associated with persistent and transient bovine mastitis and the role of colanic acid. Infection and Immunity. 86(1):e00566-17. https://doi.org/10.1128/IAI.00566-17.

Monitoring bottlenose dolphin leukocyte cytokine mRNA responsiveness by qPCR -

Hofstetter, A.R., Eberle, K.C., Venn-Watson, S.K., Jensen, E.D., Porter, T.J., Waters, T.E., Sacco, R.E. 2017. Monitoring bottlenose dolphin leukocyte cytokine mRNA responsiveness by qPCR. PLoS One. 12(12):e0189437. https://doi.org/10.1371/journal.pone.0189437.

Identification of monoclonal antibodies cross-reactive with bottlenose dolphin orthologues of the major histocompatibility complex and leukocyte differentiation molecules -

Elnaggar, M.M., Abdellrazeq, G.S., Venn-Watson, S.K., Jensen, E.D., Mack, V., Fry, L.M., Sacco, R.E., Davis, W.C. 2017. Identification of monoclonal antibodies cross-reactive with bottlenose dolphin orthologues of the major histocompatibility complex and leukocyte differentiation molecules. Developmental and Comparative Immunology. 192(2017)54-59.

Longitudinal monitoring of bottlenose dolphin leukocyte cytokine mRNA responsiveness by qPCR -

Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni

Dassanayake, R.P., Falkenberg, S.M., Briggs, R.E., Tatum, F.M., Sacco, R.E. 2017. Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni. PLoS One. 12(8):1-14. doi. 10.1371/journal.pone.0183610.

Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni -

Genome sequences of Escherichia coli strains that cause persistent and transient mastitis -

Thacker, T.C., Lippolis, J.D., Brunelle, B.W., Casey, T., Reinhardt, T.A., Sacco, R.E., Holman, D.B. 2017. Genome sequences of Escherichia coli strains that cause persistent and transient mastitis. Genome Announcements. 5(34):e00775-17. https://doi.org/10.1128/genomeA.00775-17.

Development of specific cytokine and Chemokine ELISAs for Bottlenose Dolphins -

Vitamin D status of dairy cattle: Outcomes of current practices in the dairy industry

Nelson, C.D., Lippolis, J.D., Reinhardt, T.A., Sacco, R.E., Powell, T.L., Drewnoski, M.E., O'Neill, M., Beitz, D.C., Weiss, W.P. 2016. Vitamin D status of dairy cattle: Outcomes of current practices in the dairy industry. Journal of Dairy Science. 99:10150-10160.

Bovine viral diarrhea virus type 2 impairs macrophage responsiveness to toll-like receptor ligation with the exception of toll-like receptor 7

Schaut, R.G., Ridpath, J.F., Sacco, R.E. 2016. Bovine viral diarrhea virus type 2 impairs macrophage responsiveness to toll-like receptor ligation with the exception of toll-like receptor 7. PLoS One. 11(7):e0159491. doi: 10.1371/journal.pone.0159491.

Differential gene expression of three mastitis-causing Escherichia coli strains grown under planktonic, swimming, and swarming culture conditions

Lippolis, J.D., Brunelle, B.W., Reinhardt, T.A., Sacco, R.E., Thacker, T.C., Looft, T.P., Casey, T. 2016. Differential gene expression of three mastitis-causing Escherichia coli strains grown under planktonic, swimming, and swarming culture conditions. mSystems. 1(4):e00064-16.

Bovine gamma delta T cells contribute to exacerbated IL-17 production in response to co-infection with Bovine RSV and Mannheimia haemolytica -

McGill, J.L., Rusk, R.A., Guerra-Maupome, M., Briggs, R.E., Sacco, R.E. 2016. Bovine gamma delta T cells contribute to exacerbated IL-17 production in response to co-infection with Bovine RSV and Mannheimia haemolytica. PLoS One. 11(3):e0151083. doi: 10.1371/journal.pone.0151083.

Gamma delta T cells and the immune response to respiratory syncytial virus infection

McGill, J.L., Sacco, R.E. 2016. Gamma delta T cells and the immune response to respiratory syncytial virus infection. Veterinary Immunology and Immunopathology. doi: 10.1016/j.vetimm.2016.02.012.

Parainfluenza virus 3 blocks antiviral mediators downstream of the interferon lambda receptor by modulating stat1 phosphorylation

Eberle, K.C., McGill, J.L., Reinhardt, T.A., Sacco, R.E. 2016. Parainfluenza virus 3 blocks antiviral mediators downstream of the interferon lambda receptor by modulating stat1 phosphorylation. Journal of Virology. 90:2948-2958. doi:10.1128/JVI.02502-15.

Novel Atlantic bottlenose dolphin parainfluenza virus TtPIV-1 clusters with bovine PIV-3 genotype B strains

Eberle, K.C., Neill, J.D., Venn-Watson, S.K., McGill, J.L., Sacco, R.E. 2015. Novel Atlantic bottlenose dolphin parainfluenza virus TtPIV-1 clusters with bovine PIV-3 genotype B strains. Virus Genes. 51:198-208. doi: 10.1007/s11262-015-1224-7.

Animal models of respiratory syncytial virus infection and disease

Sacco, R.E., Durbin, R.K., Durbin, J.E. 2015. Animal models of respiratory syncytial virus infection and disease. Current Opinion in Virology. 13:117-122. doi: 10.1016/j.coviro.2015.06.003.

Bovine viral diarrhea virus type 2 in vivo infection modulates TLR4 responsiveness in differentiated Myeloid cells which is associated with decreased MyD88 expression

Schaut, R.G., McGill, J.L., Neill, J.D., Ridpath, J.F., Sacco, R.E. 2015. Bovine viral diarrhea virus type 2 in vivo infection modulates TLR4 responsiveness in differentiated Myeloid cells which is associated with decreased MyD88 expression. Virus Research. 208:44-55. DOI: 10.1016/j.viruses.2015.05.017.

Innate and adaptive immune responses to in utero infection with bovine viral diarrhea virus

Hansen, T.R., Smirnova, N.P., Webb, B.T., Bielefeldt-Ohmann, H., Sacco, R.E., Van Campen, H. 2015. Innate and adaptive immune responses to in utero infection with bovine viral diarrhea virus. Animal Health Research Reviews. 16(1):15-26. DOI: 10.1017/S1466252315000122.

Immune responses of bison and efficacy after booster vaccination with Brucella abortus strain RB51

Olsen, S.C., McGill, J.L., Sacco, R.E., Hennager, S.G. 2015. Immune responses of bison and efficacy after booster vaccination with Brucella abortus strain RB51. Clinical and Vaccine Immunology. 22(4):440-447. doi: 10.1128/CVI.00746-14.

MicroRNA expression profiling in tonsils of calves challenged with a laboratory strain or field isolates of Bovine Respiratory Syncytial Virus -

Proteomic analysis reveals protein expression differences in Escherichia coli strains associated with persistent versus transient mastitis

Lippolis, J.D., Brunelle, B.W., Reinhardt, T.A., Sacco, R.E., Nonnecke, B.J., Dogan, B., Simpson, K., Schukken, Y. 2014. Proteomic analysis reveals protein expression differences in Escherichia coli strains associated with persistent versus transient mastitis. Journal of Proteomics. 108:373-381. DOI: 10.1016/j.jprpt.2014.06.008.

Acute phase response elicited by experimental bovine diarrhea virus (BVDV) infection is associated with decreased vitamin D and E status of vitamin-replete preruminant calves

Nonnecke, B.J., McGill, J.L., Ridpath, J.F., Sacco, R.E., Lippolis, J.D., Reinhardt, T.A. 2014. Acute phase response elicited by experimental bovine diarrhea virus (BVDV) infection is associated with decreased vitamin D and E status of vitamin-replete preruminant calves. Journal of Dairy Science. 97(9):5566-5579. DOI: 10.3168/jds.2014-8293.

The role of gamma delta T cells in immunity to Mycobacterium bovis infection in cattle

McGill, J.L., Sacco, R.E., Baldwin, C.L., Telfer, J.C., Palmer, M.V., Waters, W.R. 2014. The role of gamma delta T cells in immunity to Mycobacterium bovis infection in cattle. Veterinary Immunology and Immunopathology. 159(3-4)133-143. doi.org/10.1016/j.vetimm.2014.02.010.

Changes observed in the thymus and lymph nodes 14 days after exposure to BVDV field strains of enhanced or typical virulence in neonatal calves

Falkenberg, S.M., Johnson, C., Bauermann, F.V., McGill, J.L., Palmer, M.V., Sacco, R.E., Ridpath, J.F. 2014. Changes observed in the thymus and lymph nodes 14 days after exposure to BVDV field strains of enhanced or typical virulence in neonatal calves. Veterinary Immunology and Immunopathology. 160(1-2):70-80. DOI: 10.1016/j.vetimm.2014.03.018.

The Ca2+/H+ antiporter TMEM165 expression, localization in the developing, lactating and involuting mammary gland parallels the secretory pathway Ca2+ATPase (SPCA1)

Reinhardt, T.A., Lippolis, J.D., Sacco, R.E. 2014. The Ca2+/H+ antiporter TMEM165 expression, localization in the developing, lactating and involuting mammary gland parallels the secretory pathway Ca2+ATPase (SPCA1). Biochemical and Biophysical Research Communications. 445(2):417-421.

Induction of interferon-gamma and downstream pathways during establishment of fetal persistent infection with bovine viral diarrhea virus

Smirnova, N.P., Webb, B.T., McGill, J.L., Schaut, R.G., Bielefeldt-Ohmann, H., Van Campen, H., Sacco, R.E., Hansen, T.R. 2014. Induction of interferon-gamma and downstream pathways during establishment of fetal persistent infection with bovine viral diarrhea virus. Virus Research. 183:95-106. DOI: 10.1016/j.virusres.2014.02.002.

Specific recognition of mycobacterial protein and peptide antigens by gamma-delta T cell subsets following infection with virulent Mycobacterium bovis

McGill, J.L., Sacco, R.E., Baldwin, C.L., Telfer, J.C., Palmer, M.V., Waters, W.R. 2014. Specific recognition of mycobacterial protein and peptide antigens by gamma-delta T cell subsets following infection with virulent Mycobacterium bovis. Journal of Immunology. 192(6):2756-2769. doi.org/10.4049/jimmunol.1302567.

Human respiratory syncytial virus Memphis 37 grown in HEp-2 cells causes more severe disease in lambs than virus grown in vero cells

Derscheid, R.J., van Geelen, A., McGill, J.L., Gallup, J.M., Cihlar, T., Sacco, R.E., Ackermann, M.R. 2013. Human respiratory syncytial virus Memphis 37 grown in HEp-2 cells causes more severe disease in lambs than virus grown in vero cells. Viruses. 5(11):2881-2897. DOI: 10.3390/v5112881.

Specific recognition of mycobacterial protein and peptide antigens by gamma-delta T cell subsets following infection with virulent Mycobacterium bovis -

Mcgill, J.L., Sacco, R.E., Baldwin, C., Telfer, J.C., Palmer, M.V., Waters, W.R. 2013. Specific recognition of mycobacterial protein and peptide antigens by gamma-delta T cell subsets following infection with virulent Mycobacterium bovis [abstract]. Australasian Society of Immunology. Abstract No. 24.

Neonatal calf infection with respiratory syncytial virus: drawing parallels to the disease in human infants -

Sacco, R.E., McGill, J.L., Palmer, M.V., Lippolis, J.D., Reinhardt, T.A., Nonnecke, B.J. 2014. Neonatal calf infection with respiratory syncytial virus: drawing parallels to the disease in human infants. In: Rosenberg, H.F., Domachowske, J.B., editors. Pneumoviruses and Metapneumoviruses. Basel, Switzerland: MDPI AG. p. 46-69.

Proteomic differences between Escherichia coli strains that cause transient versus persistent intramammary infections [abstract] -

Development and application of specific cytokine assays in tissue samples from a bottlenose dolphin with hyperinsulinemia

Eberle, K., Waters, T.E., Jensen, E.D., Venn-Watson, S., Sacco, R.E. 2013. Development and application of specific cytokine assays in tissue samples from a bottlenose dolphin with hyperinsulinemia. Frontiers in Endocrinology. 4:134. DOI: 10.3389/fendo.2013.00134.

Respiratory syncytial virus infection in cattle -

Sacco, R.E., McGill, J.L., Pillatzki, A.E., Palmer, M.V., Ackermann, M.R. 2014. Respiratory syncytial virus infection in cattle. Veterinary Pathology. 51(2):427-436. DOI: 10.1177/0300985813501341.

Evaluation of enzyme-linked immunosorbent assays for detection of Mycoplasma bovis-Specific antibody in bison sera

Register, K.B., Sacco, R.E., Olsen, S.C. 2013. Evaluation of enzyme-linked immunosorbent assays for detection of Mycoplasma bovis-Specific antibody in bison sera. Clinical and Vaccine Immunology. 20(9):1405-1409 DOI: 10.1128/CVI.00409-13.

Mycoplasma bovis research update

Register, K.B., Sacco, R.E., Olsen, S.C. 2013. Mycoplasma bovis research update. Trade Journal Publication. Available: http://www.bisoncentral.com.

Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis

Reinhardt, T.A., Sacco, R.E., Nonnecke, B.J., Lippolis, J.D. 2013. Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis. Journal of Proteomics. 82:141-154.

Differential chemokine and cytokine production by neonatal bovine gamma delta T-cell subsets in response to viral toll-like receptor agonists and in vivo respiratory syncytial virus infection

McGill, J.L., Nonnecke, B.J., Lippolis, J.D., Reinhardt, T.A., Sacco, R.E. 2013. Differential chemokine and cytokine production by neonatal bovine gamma delta T-cell subsets in response to viral toll-like receptor agonists and in vivo respiratory syncytial virus infection. Immunology. 139(2):227-244.

Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature and serum proinflammatory cytokine and haptog -

Richeson, J.T., Kegley, E.B., Powell, J.G., Schaut, R.G., Sacco, R.E., Ridpath, J.F. 2013. Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature and serum proinflammatory cytokine and haptog. Journal of Animal Science. 91(3):1400-1408 DOI:10.2527/jas.2011-4875.

Neonatal calf infection with respiratory syncytial virus: drawing parallels to the disease in human infants -

Sacco, R.E., McGill, J.L., Palmer, M.V., Lippolis, J.D., Reinhardt, T.A., Nonnecke, B.J. 2012. Neonatal calf infection with respiratory syncytial virus: drawing parallels to the disease in human infants. Viruses. 4(12):3731-3753.

Bovine viral diarrhea virus modulation of monocyte derived macrophages -

Vitamin D signaling in the bovine immune system: A model for understanding human vitamin D requirements -

Nelson, C.D., Reinhardt, T.A., Lippolis, J.D., Sacco, R.E., Nonnecke, B.J. 2012. Vitamin D signaling in the bovine immune system: A model for understanding human vitamin D requirements. Nutrients. 4(3):181-196.

Differential expression of cytokines in response to respiratory syncytial virus infection of calves with high or low circulating 25-hydroxyvitamin D3 -

Sacco, R.E., Nonnecke, B.J., Palmer, M.V., Waters, W.R., Lippolis, J.D., Reinhardt, T.A. 2012. Differential expression of cytokines in response to respiratory syncytial virus infection of calves with high or low circulating 25-hydroxyvitamin D3. PLoS One. 7(3):e33074. Available: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033074.

Correlating levels of type III secretion and secreted proteins with fecal shedding of Escherichia coli O157:H7 in cattle -

Sharma, V.K., Sacco, R.E., Kunkle, R.A., Bearson, S.M., Palmquist, D.E. 2012. Correlating levels of type III secretion and secreted proteins with fecal shedding of Escherichia coli O157:H7 in cattle. Infection and Immunity. 80(4):1333-1342.

Bovine milk exosome proteome -

Reinhardt, T.A., Lippolis, J.D., Nonnecke, B.J., Sacco, R.E. 2012. Bovine milk exosome proteome. Journal of Proteomics. 75(5):1486-1492.

Mechanisms regulating immunity and disease severity following high and low virulence BVDV type 2 infection in neonatal calves -

McGill, J.L., Schaut, R.G., Neill, J.D., Ridpath, J.F., Sacco, R.E. 2011. Mechanisms regulating immunity and disease severity following high and low virulence BVDV type 2 infection in neonatal calves [abstract]. In: Proceedings of the U.S. Bovine Viral Diarrhea Virus Symposium, November 17-18, 2011, San Diego, California. p. 67.

Bovine viral diarrhea virus modulations of monocyte derived macrophages -

Schaut, R.G., McGill, J.L., Neill, J.D., Ridpath, J.F., Sacco, R.E. 2011. Bovine viral diarrhea virus modulations of monocyte derived macrophages [abstract]. In: Proceedings of the U.S. Bovine Viral Diarrhea Virus Symposium, November 17-18, 2011, San Diego, Calfornia. p. 69.

Characterization of viral replication and the immune response in bison peripheral blood mononuclear cells following in vitro bovine viral diarrhea virus infection -

McGill, J.L., Schaut, R.G., Neill, J.D., Olsen, S.C., Ridpath, J.F., Sacco, R.E. 2011. Characterization of viral replication and the immune response in bison peripheral blood mononuclear cells following in vitro bovine viral diarrhea virus infection [abstract]. In: Proceedings of the U.S. Bovine Viral Diarrhea Virus Symposium, November 17-18, 2011, San Diego, California. p. 59.

Treatment of an intramammary bacterial infection with 25-hydroxyvitamin D3 -

Lippolis, J.D., Reinhardt, T.A., Sacco, R.E., Nonnecke, B.J., Nelson, C.D. 2011. Treatment of an intramammary bacterial infection with 25-hydroxyvitamin D3. PLoS One. 6(10):e25479. Available: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184989/pdf/pone.0025479.pdf.

Richeson, J.T., Kegley, E.B., Powell, J.G., Galloway, D.L., Hornsby, J.A., Schaut, R.G., Sacco, R.E., Ridpath, J.F. 2012. Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature, peripheral blood leukocytes and serum proinflammatory cytokine and haptoglobin concentrations. Arkansas Animal Science Department Report 2011. AAES Research Series 597. p. 34-39.

Richeson, J.T., Kegley, E.B., Powell, R.G., Schaut, R.G., Sacco, R.E., Ridpath, J.F. 2011. Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature, peripheral blood leukocytes and serum proinflammatory cytokine concentrations [abstract]. Joint Annual Meeting American Dairy Science Association-American Society of Animal Science. Journal of Animal Science 89(E-Suppl. 1)/J. Dairy Sci. 94(E-Suppl.1). p. 157. Available: http://www.jtmtg.org/2011/abstracts/0157.PDF.

Porcine TLR3 characterization and expression in response to influenza virus and Bordetella bronchiseptica -

Sacco, R.E., Nicholson, T.L., Waters, T.E., Brockmeier, S. 2011. Porcine TLR3 characterization and expression in response to influenza virus and Bordetella bronchiseptica. Veterinary Immunology and Immunopathology. 142(1-2):57-63.

Neonatal and Adult AMphi Upregulate Cytokine Gene Transcription Via p38 MAPK Signaling in Response to RSV -

Schaut, R., Levy, N., Sacco, R.E. 2010. Neonatal and Adult AMphi Upregulate Cytokine Gene Transcription Via p38 MAPK Signaling in Response to RSV [abstract]. Autumn Immunology Conference. 39:26.

Modeling Bovine Respiratory Syncytial Virus Infection -

Sacco, R.E., Waters, W.R., Palmer, M.V., Nonnecke, B.J. 2010. Modeling Bovine Respiratory Syncytial Virus Infection [abstract]. The Association for Veterinary Teaching and Research Work. p. 6.

Bovine Viral Diarrhea Virus Modulation of Monocyte Derived Macrophage -

Schaut, R.G., Ridpath, J.F., Neill, J.D., Sacco, R.E. 2010. Bovine Viral Diarrhea Virus Modulation of Monocyte Derived Macrophage [abstract]. American Association of Veterinary Laboratory Diagnosticians. p. 241.

Influenza Virus Coinfection with Bordetella bronchiseptica Enhances Bacterial Colonization and Host Responses Exacerbating Pulmonary Lesions

Loving, C.L., Brockmeier, S.L., Vincent, A.L., Palmer, M.V., Sacco, R.E., Nicholson, T.L. 2010. Influenza Virus Coinfection with Bordetella bronchiseptica Enhances Bacterial Colonization and Host Responses Exacerbating Pulmonary Lesions. Microbial Pathogenesis. 49(5):237-245.

Differential Expression of Cytokine Transcripts in Neonatal and Adult Ovine Alveolar Macrophages in Response to Respiratory Syncytial Virus or Toll-Like Receptor Ligation -

Fach, S.J., Olivier, A., Gallup, J.M., Waters, T.E., Ackermann, M., Lehmkuhl, H.D., Sacco, R.E. 2010. Differential Expression of Cytokine Transcripts in Neonatal and Adult Ovine Alveolar Macrophages in Response to Respiratory Syncytial Virus or Toll-Like Receptor Ligation. Veterinary Immunology and Immunopathology. 136(1-2):55-64.

Swine influenza virus co-infection with Bordetella bronchiseptica enhances bacterial colonization and host immune responses exacerbating pulmonary lesions -

Loving, C.L., Brockmeier, S.L., Vincent, A.L., Palmer, M.V., Sacco, R.E., Nicholson, T.L. 2010. Swine influenza virus co-infection with Bordetella bronchiseptica enhances bacterial colonization and host immune responses exacerbating pulmonary lesions [abstract]. Conference Research Workers Disease Meeting. Paper No. 130.

Signal Regulatory Protein alpha (SIRPalpha)+ Cells in the Adaptive Response to ESAT-6/CFP-10 Protein of Tuberculous Mycobacteria

Waters, W.R., Palmer, M.V., Nonnecke, B.J., Thacker, T.C., Estes, D.M., Larsen, M.H., Jacobs, W.R., Andersen, P., Mcnair, J., Minion, F.C., Lyashchenko, K.P., Hewinson, R.G., Vordermeier, H.M., Sacco, R.E. 2009. Signal Regulatory Protein alpha (SIRPalpha)+ Cells in the Adaptive Response to ESAT-6/CFP-10 Protein of Tuberculous Mycobacteria. PLoS One [serial online]. 4(7):e6414. Available: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006414.

Laser Capture Microdissection Revisited as a Tool for Transcriptomic Analysis: Application of an Excel-Based qPCR Preparation Software (PREXCEL-Q) -

Sow, F.B., Gallup, J.M., Sacco, R.E., Ackermann, M.R. 2009. Laser Capture Microdissection Revisited as a Tool for Transcriptomic Analysis: Application of an Excel-Based qPCR Preparation Software (PREXCEL-Q). International Journal of Biomedical Science. 5(2):105-124.

Adenovirus-Mediated Expression of Interferon-Alpha Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus -

Brockmeier, S., Lager, K.M., Grubman, M.J., Brough, D.E., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Loving, C.L., Vorwald, A.C., Kehrli Jr, M.E., Lehmkuhl, H.D. 2009. Adenovirus-Mediated Expression of Interferon-Alpha Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus. Viral Immunology. 22(3):173-180.

The mononuclear phagocyte system and lymphocytes -

Sacco, R.E. 2009. The Mononuclear Phagocyte System and Lymphocytes. In: Cheville, N.F., editor. Ultrastructural Pathology. 2nd edition. Ames, IA: Wiley Blackwell Press. p. 268-294.

Differences in immune response of pigs challenged with a high versus low dose inoculum of porcine reproductive and respiratory syndrome virus -

Loving, C.L., Brockmeier, S.L., Vincent, A.L., Lager, K.M., Sacco, R.E. 2008. Differences in clinical disease and immune response of pigs challenged with a high-dose versus low-dose inoculum of porcine reproductive and respiratory syndrome virus. Viral Immunology. 21(3):315-325.

Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica -

Brockmeier, S., Vincent, A.L., Loving, C.L., Nicholson, T.L., Sacco, R.E. 2008. Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica. In: Proceedings of the 20th International Pig Veterinary Society Congress, June 22-26, 2008, Durban, South Africa. 1:10.

Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica -

Brockmeier, S., Loving, C.L., Nicholson, T.L., Vincent, A.L., Sacco, R.E. 2008. Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica [abstract]. American Society for Microbiology Meeting, June 2-4, 2008, Boston, Massachusetts. 2008 CDROM.

DNA vaccines against infectious agents: recent strategies for enhancing immune responses -

Sacco, R.E. 2008. DNA vaccines against infectious agents: Recent strategies for enhancing immune responses. Expert Opinion on Therapeutic Patents. 18(4):365-373.

Coinfection of Pigs with Swine Influenza Virus and Bordetella bronchiseptica -

Brockmeier, S., Vincent, A.L., Nicholson, T.L., Sacco, R.E., Palmer, M.V. 2007. Coinfection of Pigs with Swine Influenza Virus and Bordetella bronchiseptica [abstract]. In: United States Japan Natural Resources Animal and Avian Health Panel, December 5, 2007, Tsukuba, Japan. p. 25.

Veterinary Applications for Monitoring Mononuclear Cell Proliferation Using Cell Tracking Dyes -

Waters, W.R., Sacco, R.E. 2007. Veterinary Applications for Monitoring Mononuclear Cell Proliferation Using Cell Tracking Dyes. Immunological Investigations. 36(5-6):887-908.

Immune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene -

Register, K.B., Sacco, R.E., Brockmeier, S. 2007. Immune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene. Vaccine. 25(32):6118-28.

IL-4 induction in RSV-infected macrophages: examining the role of NFAT family members -

Levy, N.A., Fach, S.J., Sacco, R.E. 2007. IL-4 induction in RSV-infected macrophages: examining the role of NFAT family members [abstract]. American Association of Immunologists Proceedings. 178:B128.

Viruses as Predisposing Factors to Bacterial Pneumonia -

Lehmkuhl, H.D., Briggs, R.E., Sacco, R.E., Tatum, F.M. 2007. Viruses as Predisposing Factors to Bacterial Pneumonia [abstract]. Respiratory Disease in Mountain Sheep: Knowledge Gaps and Future Research. p. 154.

Immune Response in Mice and Swine to a DNA Vaccine Derived from the Pasteurella multocida toxin gene -

Register, K.B., Sacco, R.E., Brockmeier, S. 2007. Immune Response in Mice and Swine to a DNA Vaccine Derived from the Pasteurella multocida toxin gene[abstract]. American Society for Microbiology Meeting. May 21-25, 2007, Toronto, Canada. 2007 CD-ROM.

Coinfection with Swine Influenza Virus and Bordetella bronchiseptica in Pigs -

Brockmeier, S., Vincent, A.L., Sacco, R.E., Nicholson, T.L., Palmer, M.V. 2007. Coinfection with Swine Influenza Virus and Bordetella bronchiseptica in Pigs [abstract]. American Society for Microbiology Meeting, May 21-25,2007, Toronto, Canada. 2007 CD-ROM.

INNATE CYTOKINE RESPONSES IN PORCINE MACROPHAGE POPULATIONS: EVIDENCE FOR DIFFERENTIAL RECONGITION OF DSRNA -

Loving, C.L., Brockmeier, S., Wenjun, M., Richt, J., Sacco, R.E. 2006. Innate Cytokine Responses in Porcine Macrophage Populations: Evidence for Differential Recongition of dsRNA. Journal of Immunology. 177:8432-8439.

NEONATAL OVINE PULMONARY DENDRITIC CELLS SUPPORT BRSV REPLICATION WITH ENHANCED IL-4 AND IL-10 GENE TRANSCRIPTS -

Fach, S.J., Meyerholz, D.K., Gallup, J.M., Ackermann, M.R., Lehmkuhl, H.D., Sacco, R.E. 2007. Neonatal Ovine Pulmonary Dendritic Cells Support BRSV Replication with Enhanced IL-4 and IL-10 Gene Transcripts. Viral Immunology. 20(1):119-130.

Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus -

Loving, C.L., Brockmeier, S., Sacco, R.E. 2006. Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus. Immunology. 120:217-229.

Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus -

Brockmeier, S.L., Lager, K.M., Grubman, M.J., Brough, D., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Lehmkuhl, H.D. 2006. Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus. Proceedings of the 87th Conference of Research Workers in Animal Diseases, December 3-5, 2006. Chicago, Illinois. p.124.

Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus -

Brockmeier, S.L., Lager, K.M., Grubman, M.J., Brough, D., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Lehmkuhl, H.D. 2006. Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus. Proceeding of the International PRRS Symposium, December 1-2, 2006, Chicago, Illinois. p. 27.

IMMUNE RESPONSES OF ELK TO INITITAL AND BOOSTER VACCINATIONS WITH BRUCELLA ABORTUS STRAIN RB51 OR 19 -

Olsen, S.C., Fach, S.J., Palmer, M.V., Sacco, R.E., Stoffregen, W.C., Waters, W.R. 2006. Immune Responses of Elk to Initital and Booster Vaccinations with Brucella abortus Strain RB51 or 19. Clinical and Vaccine Immunology. 13(10):1098-1103.

DIFFERENTIAL REGULATION OF TYPE I INTERFERON ACTIVATION IN MACROPHAGES -

Loving, C.L., Brockmeier, S., Sacco, R.E. 2006. Differential regulation of type I interferon activation in macrophages [abstract]. American Association of Immunologists Proceedings. 249:43-44.

PULMONARY DENDRITIC CELLS ISOLATED FROM NEONATAL AND ADULT OVINE LUNG TISSUE -

Fach, S.J., Brockmeier, S., Hobbs, L.A., Lehmkuhl, H.D., Sacco, R.E. 2006. Pulmonary dendritic cells isolated from neonatal and adult ovine lung tissue. Veterinary Immunology and Immunopathology. 112(3-4):171-82.

COMPARATIVE NITRIC OXIDE PRODUCTION OF LPS-STIMULATED MONOCYTE-DERIVED MACROPHAGES FROM OVIS CANADENSIS AND OVIS ARIES -

Sacco, R.E., Waters, W.R., Rudolph, K.M., Drew, M.L. 2006. Comparative nitric oxide production of LPS-stimulated monocyte-derived macrophages from Ovis canadensis and Ovis aries. Comparative Immunology Microbiology and Infectious Diseases. 29(1):1-11.

NEONATAL LAMB RESPIRATORY TRACT DENDRITIC CELLS AND THE EFFECTS OF RSV INFECTION -

Fach, S.J., Meyerholz, D.K., Gallup, J.M., Ackermann, M.R., Lehmkuhl, H.D., Sacco, R.E. 2005. Neonatal lamb respiratory tract dendritic cells and the effects of RSV infection [abstract]. Federation of American Societies for Experimental Biology Conference. 19:A403.

PRRS VIRUS PRODUCTIVELY INFECTS MONOCYTE-DERIVED DENDRITIC CELLS AND INDUCES PRODUCTION OF INNATE ANTIVIRAL MEDIATORS -

Loving, C.L., Brockmeier, S., Sacco, R.E. 2005. Prrs virus productively infects monocyte-derived dendritic cells and induces production of innate antiviral mediators. Federation of American Societies for Experimental Biology Conference. 19:A404.

EFFECT OF BRSV INFECTION IN NEONATAL LAMBS ON RESPIRATORY TRACT DENDRITIC CELLS -

Fach, S.J., Meyerholz, D.K., Gallup, J.M., Ackermann, M.R., Lehmkuhl, H.D., Sacco, R.E. 2004. Effect of BRSV infection in neonatal lambs on respiratory tract dendritic cells [abstract]. Autumn Immunology Conference. p. 52.

INNATE IMMUNITY OF RESPIRATORY EPITHELIA: EFFECTS OF PRETERM BIRTH AND RESPIRATORY SYNCYTIAL VIRUS INFECTION -

Ackermann, M.R., Meyerholz, D.K., Grubor, B., Lehmkuhl, H.D., Sacco, R.E., Gallup, J.M., Derscheid, R., Lazic, T., Fach, S., Kawashima, K. 2004. Innate immunity of respiratory epithelia: effects of preterm birth and respiratory syncytial virus infection [abstract]. Conference of Research Workers in Animal Diseases. p. 136.

INCREASED SEVERITY OF BOVINE RESPIRATORY SYNCYTIAL VIRUS INFECTION IN PRETERM LAMBS -

Meyerholz, D.K., Grubor, B., Fach, S.J., Sacco, R.E., Lehmkuhl, H.D., Gallup, J.M., Ackermann, M.R. 2004. Increased severity of bovine respiratory syncytial virus infection in preterm lambs [abstract]. Bi-Annual All-Iowa Virology Symposium. Paper No. 12.

COMPARISON OF THE EXPRESSED PORCINE VBETA AND JBETA REPERTOIRE OF THYMOCYTES AND PERIPHERAL T-CELLS -

Butler, J.E., Wertz, N., Sun, J., Sacco, R.E. 2005. Comparison of the expressed porcine vbeta and jbeta repertoire of thymocytes and peripheral t-cells. Immunology. 114:184-193.

REDUCED CLEARANCE OF RESPIRATORY SYNCYTIAL VIRUS IN A PRETERM LAMB MODEL -

Meyerholz, D.K., Grubor, B., Fach, S.J., Sacco, R.E., Lehmkuhl, H.D., Gallup, J.M., Ackermann, M.R. 2004. Reduced clearance of respiratory syncytial virus in a preterm lamb model. Microbes and Infection. 6(14):1312-1319.

IMMUNE RESPONSE TO A DNA VACCINE DERIVED FROM THE PASTEURELLA MULTOCIDA TOXIN GENE -

Register, K.B., Sacco, R.E., Brockmeier, S. 2004. Immune response to a dna vaccine derived from the pasteurella multocida toxin gene. Pig Veterinary Society International Congress Proceedings. p. 200.

RESPIRATORY SYNCYTIAL VIRUS INFECTION IN PRETERM LAMBS -

Meyerholz, D.K., Grubor, B., Fach, S.J., Sacco, R.E., Ensley, D., Lehmkuhl, H.D., Gallup, J.M., Ackermann, M.R. Respiratory syncytial virus infection in preterm lambs. 2004. Presented at FASEB Meeting. Abstract No. 1074.

THE EFFECTS OF PASTEURELLA MULTOCIDA TOXIN (PMT) ON EARLY MURINE B-LINEAGE CELLS -

Loving, C.L., Sacco, R.E. 2003. The effects of pasteurella multocida toxin (pmt) on early murine b-lineage cells. Autumn Immunology Conference Proceedings. Abstract No. 140, p. 54.

THE EFFECTS OF PASTEURELLA MULTOCIDA TOXIN (PMT) ON EARLY MURINE B-LINEAGE CELLS -

Loving, C.L., Sacco, R.E. 2003. The effects of Pasteurella multocida toxin (pmt) on early murine b-lineage cells. Immunology Research Workshop. December 2, 2003.

ANALYSIS OF LYMPHOCYTES ISOLATED FROM WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) FAWNS -

Fach, S.J., Waters, W.R., Palmer, M.V., Davis, W.C., Sacco, R.E. 2003. Analysis of lymphocytes isolated from white-tailed deer (odocoileus virginianus) fawns. Immunology Research Workshop. December 2, 2003.

RE-EMERGENCE OF BORDETELLA BRONCHISPETICA DURING THE RECENT SEAL MORBILLIVIRUS OUTBREAK -

FOSTER, G., REGISTER, K.B., SACCO, R.E., PATTERSON, I.P. RE-EMERGENCE OF BORDETELLA BRONCHISPETICA DURING THE RECENT SEAL MORBILLIVIRUS OUTBREAK. PROCEEDINGS OF THE SCOTTISH AGRICULTURAL COLLEGE OF VETERINARY SCIENCES CONFERENCE. SEPTEMBER 10-11, 2003. p. 21.

DEFENSIN-INDUCED ADAPTIVE IMMUNITY IN MICE AND ITS POTENTIAL IN PREVENTING PERIODONTAL DISEASE -

Brogden, K.A., Heidari, M., Sacco, R.E., Palmquist, D.E., Guthmiller, J.M., Johnson, G.K., Jia, H.P., Tack, B.F., Mccray, P.B. 2003. Defensin-induced adaptive immunity in mice and its potential in preventing periodontal disease. Oral Microbiology and Immunology. Vol. 18:95-99.

COMPARISON BETWEEN RIBOTYPING AND RESTRICTION ENZYME ANALYSIS FOR INTER- AND INTRASPECIES DISCRIMINATION OF BORDETELLA AVIUM AND BORDETELLA HINZII -

REGISTER, K.B., SACCO, R.E., NORDHOLM, G.E. COMPARISON OF RIBOTYPING AND RESTRICTION ENZYME ANALYSIS FOR INTER- AND INTRASPECIES DISCRIMINATION OF BORDETELLA AVIUM AND BORDETELLA HINZII. JOURNAL OF CLINICAL MICROBIOLOGY. 2003. v. 41(4). p. 1512-1519.

IMMUNE RESPONSES OF ELK TO MYCOBACTERIUM BOVIS BACILLUS CALMETTE GUERIN VACCINATION -

Waters, W.R., Palmer, M.V., Olsen, S.C., Sacco, R.E., Whipple, D.L. 2003. Immune responses of elk to mycobacterium bovis bacillus calmette guerin vaccination. Vaccine. Vol. 21(13-14), p. 1518-1526.

DEFENSIN INDUCED ADAPTIVE IMMUNITY IN MICE AND ITS POTENTIAL IN PREVENTING PERIODONTAL DISEASE -

BROGDEN, K.A., HEIDARI, M., SACCO, R.E., PALMQUIST, D.E., GUTHMILLER, J.M., JOHNSON, G.K., JIA, H.P., TACK, B.F., MCCRAY, JR., P.B. DEFENSIN-INDUCED ADAPTIVE IMMUNITY IN MICE AND ITS POTENTIAL IN PREVENTING PERIODONTAL DISEASE. ORAL MICROBIOLOGY AND IMMUNOLOGY. 2003. v. 18. p. 95-99.

ANALYSIS OF LYMPHOCYTES ISOLATED FROM WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) FAWNS -

BHUR, A VIRULENCE-ASSOCIATED OUTER MEMBRANE PROTEIN OF BORDETELLA AVIUM, IS REQUIRED FOR THE ACQUISITION OF IRON FROM HEME AND HEMOPROTEINS -

MURPHY, E.R., SACCO, R.E., DICKENSON, A., METZGER, D.J., HU, Y., ORNDORFF, P.E., CONNELL, T.D. BHUR, A VIRULENCE-ASSOCIATED OUTER MEMBRANE PROTEIN OF BORDETELLA AVIUM, IS REQUIRED FOR THE ACQUISITION OF IRON FROM HEME AND HEMOPROTEINS. INFECTION AND IMMUNITY. 2002. v. 70(10). p. 5390-5403.

INDUCTION OF TH2-LIKE IMMUNE RESPONSES BY C3H MICE BEARING A DEFINED FLORA FOLLOWING ONSET OF COLITIS -

ESTABLISHED TH1 GRANULOMATOUS RESPONSES INDUCED BY ACTIVE MYCOBACTERIUM AVIUM INFECTION SWITCH TO TH2 FOLLOWING CHALLENGE WITH SCHISTOSOMA MANSONI -

SACCO, R.E., HAGEN, M., SANDOR, M., WEINSTOCK, J.V., LYNCH, R.G. ESTABLISHED TH1 GRANULOMATOUS RESPONSES INDUCED BY ACTIVE MYCOBACTERIUM AVIUM INFECTION SWITCH TO TH2 FOLLOWING CHALLENGE WITH SCHISTOSOMA MANSONI. Clinical Immunology. 2002. v. 104(3). p. 274-281.

ANALYSIS OF MITOGEN-STIMULATED LYMPHOCYTE SUBSET PROLIFERATION AND NITRIC OXIDE PRODUCTION BY PERIPHERAL BLOOD MONONUCLEAR CELLS OF CAPTIVE ELK (CERVUS ELAPHUS) -

NITRIC OXIDE PRODUCTION AS AN INDICATION OF MYCOBACTERIUM BOVIS INFECTION OF WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) -

NITRIC OXIDE PRODUCTION AS AN INDICATION OF MYCOBACTERIUM BOVIS INFECTION OF WHITE-TAILED DEER -

CHARACTERIZATION OF BIGHORN SHEEP (OVIS CANADENSIS) MACROPHAGES USING IMMUNOHISTOCHEMICAL, FLOW CYTOMETRIC AND FUNCTIONAL ASSAYS (POSTER PRESENTATION FOR THE 82ND CONFERENCE OF RESEARCH WORKERS IN ANIMAL DISEASE) -

PHENOTYPIC ANALYSIS OF LYMPHOCYTES ISOLATED FROM WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) FAWNS USING THREE-COLOR FLOW CYTOMETRY (POSTER PRESENTATION AT THE 82ND CONFERENCE OF RESEARCH WORKERS IN ANIMAL DISEASE) -

BETA DEFENSIN-INDUCED ADAPTIVE IMMUNE RESPONSE TO OVALBUMIN IN MICE (POSTER PRESENTATION FOR THE 101ST ASM ANNUAL MEETING, MAY 20-24, 2001) -

IDENTIFICATION OF NEW MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN A CLOSED EXPERIMENTAL LINE OF BELTSVILLE SMALL WHITE TURKEYS -

GALLINACIN-3, AN INDUCIBLE EPITHELIAL BETA DEFENSIN OF THE CHICKEN -

RESTRICTION ENDONUCLEASE ANALYSIS DISCRIMNATES BORDETELLA BRONCHISEPTICA ISOLATES -

FLOW CYTOMETRIC ANALYSIS OF COLONIC AND SMALL INTESTINAL MUCOSAL LYMPHOCYTES OBTAINED BY ENDOSCOPIC BIOPSY IN THE HEALTHY DOG -

ANTIGEN-SPECIFIC PROLIFERATION OF PORCINE CD8 ALPHA ALPHA CELLS TO AN EXTRACELLULAR BACTERIAL PATHOGEN -

REDUCTION IN INFLAMMATION FOLLOWING BLOCKADE OF CD18 OR CD29 ADHESIVE PATHWAYS DURING THE ACUTE PHASE OF A SPIROCHETAL-INDUCED COLITIS IN MICE -

RIBOTYPING AND RESTRICTION ENDONUCLEASE ANALYSIS REVEAL A NOVEL CLONE OF BORDETELLA BRONCHISEPTICA IN SEALS -

B CELLS ARE REQUIRED FOR THE INDUCTION OF INTESTINAL INFLAMMATORY LESIONS IN TCR ALPHA-DEFICIENT MICE PERSISTENTLY INFECTED WITH CRYPTOSPORIDIUM PARVUM -

RESTRICTION ENZYME ANALYSIS OF BORDETELLA BRONCHISPETICA ISOLATES -

BORDETELLA AVIUM DERMONECROTIC TOXIN INDUCES APOPTOSIS IN LYMPHOID TISSUES -

ANTIGEN-SPECIFIC PROLIFERATION OF PORCINE CD8 ALPHA ALPHA T CELLS -

POULT NEPHROPATHY INDUCED BY A BORDETELLA AVIUM TOXIN -

RESTRICTION ENZYME ANALYSIS AND RIBOTYPING DISTINGUISH BORDETELLA AVIUM AND BORDETELLA HINZII ISOLATES -

GENETIC VARIATION IN RESPONSE OF TURKEYS TO EXPERIMENTAL INFECTION WITH BORDETELLA AVIUM (RESEARCH NOTE) -

BORDETELLA AVIUM DERMONECROTIC TOXIN CAUSES LYMPHOID LESIONS IN MICE (ORAL PRESENTATION FOR THE AVMA/AAAP MTG., JULY 1999) -

CELLULAR IMMUNE RESPONSES OF PIGS INDUCED BY VACCINATION WITH EITHER A WHOLE CELL SONICATE OR PEPSIN-DIGESTED SERPULINA HYODYSENTERIAE BACTERIN -

CRYPTOSPORIDIUM PARVUM-INDUCED INFLAMMATORY BOWEL DISEASE OF TCR-BETA X TCR-DELTA-DEFICIENT MICE -

SYSTEMIC AND MUCOSAL IMMUNE RESPONSES OF PIGS TO PARENTERAL IMMUNIZATION WITH A PEPSIN-DIGESTED SERPULINA HYODYSENTERIAE BACTERIN -

MODULATION OF THE LYMPHOCYTE REPERTOIRE IN MICE FOLLOWING ADMINISTRATION OF BORDETELLA AVIUM DERMONECROTIC TOXIN (POSTER PRESENTATION FOR THE 99TH ASM GEN. MEETING, MAY 30 - JUNE 3, 1999) -

ROLE OF ACUTE PHASE CYTOKINES AND LEUKOCYTIC INFILTRATION IN A MURINE MODEL OF SPIROCHETE-INDUCED COLITIS (POSTER PRESENTATION AT THE KEYSTONE SYMPOSIA, SANTA FE, NM, JANUARY 1999) -

ANTIGEN-SPECIFIC B CELL UNRESPONSIVENESS INDUCED BY CHRONIC MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS INFECTION IN CATTLE -

ANTIGEN-SPECIFIC B CELL UNRESPONSIVENESS INDUCED BY CHRONIC MYCOBACTERIUM AVIUM SUBSP PARATUBERCULOSIS INFECTION OF CATTLE -

UTILITY OF DNA FINGERPRINTING TO DISTINGUISH BORDETELLA AVIUM, BORDETELLA HINZII AND ALCALIGENES FAECALIS ISOLATES (ORAL PRESENTATION FOR THE 33RD UNITED STATES-JAPAN NATURAL RESOURCES MYCOPLASMOSIS MTG. (UJNR) -

USE OF PKH2 TO DEMONSTRATE ANTIGEN-SPECIFIC B CELL UNRESPONSIVENESS IN CATTLE CHRONICALLY INFECTED WITH MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS -

CELLULAR IMMUNE RESPONSES OF PIGS TO PARENTERAL VACCINATION WITH A SERPULINA HYODYSENTERIAE WHOLE CELL SONICATE OR PEPSIN-DIGEST BACTERIN -

DNA FINGERPRINTING OF BORDETELLA AVIUM AND BORDETELLA HINZII ISOLATES -

CRYPTOSPORIDIUM PARVUM INITIATES INFLAMMATORY BOWEL DISEASE IN GERMFREE T CELL RECEPTOR-ALPHA-DEFICIENT MICE -

FLOW CYTOMETRIC ANALYSIS OF CANINE COLONIC MUCOSAL LYMPHOCYTES OBTAINED FROM ENDOSCOPIC BIOPSIES -

SUSCEPTIBILITY OF CONVALESCENT TURKEYS TO PULMONARY ASPERGILLOSIS (RESEARCH NOTE) -

INFECTION WITH CRYPTOSPORIDIUM PARVUM INITIATES INFLAMMATORY BOWEL DISEASE IN GERM-FREE TCR-ALPHA-DEFICIENT MICE -

Agricultural Research Service

Ruminant Diseases and Immunology Research: Ames, IA