Submitted to: Expert Opinion on Therapeutic Patents
Publication Type: Review Article
Publication Acceptance Date: 2/8/2008
Publication Date: 4/18/2008
Citation: Sacco, R.E. 2008. DNA vaccines against infectious agents: Recent strategies for enhancing immune responses. Expert Opinion on Therapeutic Patents. 18(4):365-373. Interpretive Summary:
Technical Abstract: There have been widespread efforts to develop plasmid DNA vaccines against animal and human pathogens, and for use as therapies in the treatment of cancers, autoimmune diseases, and allergies. The impetus for this research activity was based on early promising results in laboratory animals that showed DNA vaccines induce antibody and cell-mediated immune responses, as well as protection against an infectious challenge. However, first generation DNA vaccines have generally not induced optimal responses in large animals and humans. Considerable effort has been directed at enhancing immune responses to DNA vaccines through several lines of research development. The recent advances that have been made in DNA vaccines for infectious diseases are reviewed.