Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 3/18/2012
Publication Date: N/A
Citation: Interpretive Summary:
Technical Abstract: Bovine viral diarrhea virus (BVDV) is a single stranded, positive sense RNA virus and is the causative agent of bovine viral diarrhea (BVD). Disease can range from persistently infected (PI) animals displaying no clinical symptoms of disease to an acute, severe disease. Presently, limited studies have focused on specific immune cell function or cytokine response to BVDV, especially in regard to paired biotypes. The objective of this study is to examine the effects of paired BVDV2 biotypes (cytopathic [CP], noncytopathic [NCP], high virulence [HV] and low virulence [LV]) on monocyte-derived macrophages (MDM) both in an in vitro and in vivo setting, and to elucidate the mechanisms by which BVDV can contribute to immunosuppression.