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United States Department of Agriculture

Agricultural Research Service

Related Topics

Randy E Sacco
Ruminant Diseases and Immunology Research
Microbiology

Phone: (515) 337-7354
Fax: (515) 337-7149
Room 1131

1920 DAYTON AVE
AMES , IA 50010

Projects
Development of Atlantic Bottlenose Dolphin Cytokine Assays
General Cooperative Agreement (A)
  Accession Number: 430025
IDENTIFICATION OF DISEASE MECHANISMS AND CONTROL STRATEGIES FOR BACTERIAL RESPIRATORY PATHOGENS IN CATTLE
Appropriated (D)
  Accession Number: 422104
INTERVENTION STRATEGIES TO CONTROL VIRAL DISEASES OF CATTLE
Appropriated (D)
  Accession Number: 422148
Development of Atlantic Bottlenose Dolphin Cytokine Assays
Interagency Reimbursable Agreement (I)
  Accession Number: 427779
A Novel Approach to RSV Vaccination
Reimbursable (R)
  Accession Number: 427517

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Vitamin D status of dairy cattle: Outcomes of current practices in the dairy industry -
Bovine viral diarrhea virus type 2 impairs macrophage responsiveness to toll-like receptor ligation with the exception of toll-like receptor 7 Reprint Icon -
Schaut, R.G., Ridpath, J.F., Sacco, R.E. 2016. Bovine viral diarrhea virus type 2 impairs macrophage responsiveness to toll-like receptor ligation with the exception of toll-like receptor 7. PLoS One. 11(7):e0159491. doi: 10.1371/journal.pone.0159491.
Differential gene expression of three mastitis-causing Escherichia coli strains grown in planktonic, swimming, and swarming culture conditions -
Lippolis, J.D., Brunelle, B.W., Reinhardt, T.A., Sacco, R.E., Thacker, T.C., Looft, T.P., Casey, T. 2016. Differential gene expression of three mastitis-causing Escherichia coli strains grown in planktonic, swimming, and swarming culture conditions. mSystems. 1(4):e00064-16.
Bovine gamma delta T cells contribute to exacerbated IL-17 production in response to co-infection with Bovine RSV and Mannheimia haemolytica -
McGill, J.L., Rusk, R.A., Guerra-Maupome, M., Briggs, R.E., Sacco, R.E. 2016. Bovine gamma delta T cells contribute to exacerbated IL-17 production in response to co-infection with Bovine RSV and Mannheimia haemolytica. PLoS One. 11(3):e0151083. doi: 10.1371/journal.pone.0151083.
Gamma delta T cells and the immune response to respiratory syncytial virus infection Reprint Icon -
McGill, J.L., Sacco, R.E. 2016. Gamma delta T cells and the immune response to respiratory syncytial virus infection. Veterinary Immunology and Immunopathology. doi: 10.1016/j.vetimm.2016.02.012.
Parainfluenza virus 3 blocks antiviral mediators downstream of the interferon lambda receptor by modulating stat1 phosphorylation Reprint Icon -
Eberle, K.C., McGill, J.L., Reinhardt, T.A., Sacco, R.E. 2016. Parainfluenza virus 3 blocks antiviral mediators downstream of the interferon lambda receptor by modulating stat1 phosphorylation. Journal of Virology. 90:2948-2958. doi:10.1128/JVI.02502-15.
Novel Atlantic bottlenose dolphin parainfluenza virus TtPIV-1 clusters with bovine PIV-3 genotype B strains Reprint Icon -
Eberle, K.C., Neill, J.D., Venn-Watson, S.K., McGill, J.L., Sacco, R.E. 2015. Novel Atlantic bottlenose dolphin parainfluenza virus TtPIV-1 clusters with bovine PIV-3 genotype B strains. Virus Genes. 51:198-208. doi: 10.1007/s11262-015-1224-7.
Animal models of respiratory syncytial virus infection and disease Reprint Icon -
Sacco, R.E., Durbin, R.K., Durbin, J.E. 2015. Animal models of respiratory syncytial virus infection and disease. Current Opinion in Virology. 13:117-122. doi: 10.1016/j.coviro.2015.06.003.
Bovine viral diarrhea virus type 2 in vivo infection modulates TLR4 responsiveness in differentiated Myeloid cells which is associated with decreased MyD88 expression Reprint Icon -
Schaut, R.G., McGill, J.L., Neill, J.D., Ridpath, J.F., Sacco, R.E. 2015. Bovine viral diarrhea virus type 2 in vivo infection modulates TLR4 responsiveness in differentiated Myeloid cells which is associated with decreased MyD88 expression. Virus Research. 208:44-55. DOI: 10.1016/j.viruses.2015.05.017.
Innate and adaptive immune responses to in utero infection with bovine viral diarrhea virus Reprint Icon -
Hansen, T.R., Smirnova, N.P., Webb, B.T., Bielefeldt-Ohmann, H., Sacco, R.E., Van Campen, H. 2015. Innate and adaptive immune responses to in utero infection with bovine viral diarrhea virus. Animal Health Research Reviews. 16(1):15-26. DOI: 10.1017/S1466252315000122.
Immune responses of bison and efficacy after booster vaccination with Brucella abortus strain RB51 Reprint Icon -
Olsen, S.C., McGill, J.L., Sacco, R.E., Hennager, S.G. 2015. Immune responses of bison and efficacy after booster vaccination with Brucella abortus strain RB51. Clinical and Vaccine Immunology. 22(4):440-447. doi: 10.1128/CVI.00746-14.
MicroRNA expression profiling in tonsils of calves challenged with a laboratory strain or field isolates of Bovine Respiratory Syncytial Virus -
Proteomic analysis reveals protein expression differences in Escherichia coli strains associated with persistent versus transient mastitis Reprint Icon -
Lippolis, J.D., Brunelle, B.W., Reinhardt, T.A., Sacco, R.E., Nonnecke, B.J., Dogan, B., Simpson, K., Schukken, Y. 2014. Proteomic analysis reveals protein expression differences in Escherichia coli strains associated with persistent versus transient mastitis. Journal of Proteomics. 108:373-381. DOI: 10.1016/j.jprpt.2014.06.008.
Acute phase response elicited by experimental bovine diarrhea virus (BVDV) infection is associated with decreased vitamin D and E status of vitamin-replete preruminant calves Reprint Icon -
Nonnecke, B.J., McGill, J.L., Ridpath, J.F., Sacco, R.E., Lippolis, J.D., Reinhardt, T.A. 2014. Acute phase response elicited by experimental bovine diarrhea virus (BVDV) infection is associated with decreased vitamin D and E status of vitamin-replete preruminant calves. Journal of Dairy Science. 97(9):5566-5579. DOI: 10.3168/jds.2014-8293.
The role of gamma delta T cells in immunity to Mycobacterium bovis infection in cattle Reprint Icon -
McGill, J.L., Sacco, R.E., Baldwin, C.L., Telfer, J.C., Palmer, M.V., Waters, W.R. 2014. The role of gamma delta T cells in immunity to Mycobacterium bovis infection in cattle. Veterinary Immunology and Immunopathology. 159(3-4)133-143. doi.org/10.1016/j.vetimm.2014.02.010.
Changes observed in the thymus and lymph nodes 14 days after exposure to BVDV field strains of enhanced or typical virulence in neonatal calves Reprint Icon -
Falkenberg, S.M., Johnson, C., Bauermann, F.V., McGill, J.L., Palmer, M.V., Sacco, R.E., Ridpath, J.F. 2014. Changes observed in the thymus and lymph nodes 14 days after exposure to BVDV field strains of enhanced or typical virulence in neonatal calves. Veterinary Immunology and Immunopathology. 160(1-2):70-80. DOI: 10.1016/j.vetimm.2014.03.018.
The Ca2+/H+ antiporter TMEM165 expression, localization in the developing, lactating and involuting mammary gland parallels the secretory pathway Ca2+ATPase (SPCA1) Reprint Icon -
Reinhardt, T.A., Lippolis, J.D., Sacco, R.E. 2014. The Ca2+/H+ antiporter TMEM165 expression, localization in the developing, lactating and involuting mammary gland parallels the secretory pathway Ca2+ATPase (SPCA1). Biochemical and Biophysical Research Communications. 445(2):417-421.
Induction of interferon-gamma and downstream pathways during establishment of fetal persistent infection with bovine viral diarrhea virus Reprint Icon -
Smirnova, N.P., Webb, B.T., McGill, J.L., Schaut, R.G., Bielefeldt-Ohmann, H., Van Campen, H., Sacco, R.E., Hansen, T.R. 2014. Induction of interferon-gamma and downstream pathways during establishment of fetal persistent infection with bovine viral diarrhea virus. Virus Research. 183:95-106. DOI: 10.1016/j.virusres.2014.02.002.
Specific recognition of mycobacterial protein and peptide antigens by gamma-delta T cell subsets following infection with virulent Mycobacterium bovis Reprint Icon -
McGill, J.L., Sacco, R.E., Baldwin, C.L., Telfer, J.C., Palmer, M.V., Waters, W.R. 2014. Specific recognition of mycobacterial protein and peptide antigens by gamma-delta T cell subsets following infection with virulent Mycobacterium bovis. Journal of Immunology. 192(6):2756-2769. doi.org/10.4049/jimmunol.1302567.
Human respiratory syncytial virus Memphis 37 grown in HEp-2 cells causes more severe disease in lambs than virus grown in vero cells Reprint Icon -
Derscheid, R.J., van Geelen, A., McGill, J.L., Gallup, J.M., Cihlar, T., Sacco, R.E., Ackermann, M.R. 2013. Human respiratory syncytial virus Memphis 37 grown in HEp-2 cells causes more severe disease in lambs than virus grown in vero cells. Viruses. 5(11):2881-2897. DOI: 10.3390/v5112881.
Specific recognition of mycobacterial protein and peptide antigens by gamma-delta T cell subsets following infection with virulent Mycobacterium bovis -
Mcgill, J.L., Sacco, R.E., Baldwin, C., Telfer, J.C., Palmer, M.V., Waters, W.R. 2013. Specific recognition of mycobacterial protein and peptide antigens by gamma-delta T cell subsets following infection with virulent Mycobacterium bovis [abstract]. Australasian Society of Immunology. Abstract No. 24.
Neonatal calf infection with respiratory syncytial virus: drawing parallels to the disease in human infants -
Sacco, R.E., McGill, J.L., Palmer, M.V., Lippolis, J.D., Reinhardt, T.A., Nonnecke, B.J. 2014. Neonatal calf infection with respiratory syncytial virus: drawing parallels to the disease in human infants. In: Rosenberg, H.F., Domachowske, J.B., editors. Pneumoviruses and Metapneumoviruses. Basel, Switzerland: MDPI AG. p. 46-69.
Proteomic differences between Escherichia coli strains that cause transient versus persistent intramammary infections [abstract] -
Development and application of specific cytokine assays in tissue samples from a bottlenose dolphin with hyperinsulinemia Reprint Icon -
Eberle, K., Waters, T.E., Jensen, E.D., Venn-Watson, S., Sacco, R.E. 2013. Development and application of specific cytokine assays in tissue samples from a bottlenose dolphin with hyperinsulinemia. Frontiers in Endocrinology. 4:134. DOI: 10.3389/fendo.2013.00134.
Respiratory syncytial virus infection in cattle -
Sacco, R.E., McGill, J.L., Pillatzki, A.E., Palmer, M.V., Ackermann, M.R. 2014. Respiratory syncytial virus infection in cattle. Veterinary Pathology. 51(2):427-436. DOI: 10.1177/0300985813501341.
Evaluation of enzyme-linked immunosorbent assays for detection of Mycoplasma bovis-Specific antibody in bison sera Reprint Icon -
Register, K.B., Sacco, R.E., Olsen, S.C. 2013. Evaluation of enzyme-linked immunosorbent assays for detection of Mycoplasma bovis-Specific antibody in bison sera. Clinical and Vaccine Immunology. 20(9):1405-1409 DOI: 10.1128/CVI.00409-13.
Mycoplasma bovis research update Reprint Icon -
Register, K.B., Sacco, R.E., Olsen, S.C. 2013. Mycoplasma bovis research update. Trade Journal Publication. Available: http://www.bisoncentral.com.
Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis Reprint Icon -
Reinhardt, T.A., Sacco, R.E., Nonnecke, B.J., Lippolis, J.D. 2013. Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis. Journal of Proteomics. 82:141-154.
Differential chemokine and cytokine production by neonatal bovine gamma delta T-cell subsets in response to viral toll-like receptor agonists and in vivo respiratory syncytial virus infection Reprint Icon -
McGill, J.L., Nonnecke, B.J., Lippolis, J.D., Reinhardt, T.A., Sacco, R.E. 2013. Differential chemokine and cytokine production by neonatal bovine gamma delta T-cell subsets in response to viral toll-like receptor agonists and in vivo respiratory syncytial virus infection. Immunology. 139(2):227-244.
Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature and serum proinflammatory cytokine and haptog -
Richeson, J.T., Kegley, E.B., Powell, J.G., Schaut, R.G., Sacco, R.E., Ridpath, J.F. 2013. Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature and serum proinflammatory cytokine and haptog. Journal of Animal Science. 91(3):1400-1408 DOI:10.2527/jas.2011-4875.
Neonatal calf infection with respiratory syncytial virus: drawing parallels to the disease in human infants -
Sacco, R.E., McGill, J.L., Palmer, M.V., Lippolis, J.D., Reinhardt, T.A., Nonnecke, B.J. 2012. Neonatal calf infection with respiratory syncytial virus: drawing parallels to the disease in human infants. Viruses. 4(12):3731-3753.
Bovine viral diarrhea virus modulation of monocyte derived macrophages -
Vitamin D signaling in the bovine immune system: A model for understanding human vitamin D requirements -
Nelson, C.D., Reinhardt, T.A., Lippolis, J.D., Sacco, R.E., Nonnecke, B.J. 2012. Vitamin D signaling in the bovine immune system: A model for understanding human vitamin D requirements. Nutrients. 4(3):181-196.
Differential expression of cytokines in response to respiratory syncytial virus infection of calves with high or low circulating 25-hydroxyvitamin D3 -
Sacco, R.E., Nonnecke, B.J., Palmer, M.V., Waters, W.R., Lippolis, J.D., Reinhardt, T.A. 2012. Differential expression of cytokines in response to respiratory syncytial virus infection of calves with high or low circulating 25-hydroxyvitamin D3. PLoS One. 7(3):e33074. Available: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033074.
Correlating levels of type III secretion and secreted proteins with fecal shedding of Escherichia coli O157:H7 in cattle -
Sharma, V.K., Sacco, R.E., Kunkle, R.A., Bearson, S.M., Palmquist, D.E. 2012. Correlating levels of type III secretion and secreted proteins with fecal shedding of Escherichia coli O157:H7 in cattle. Infection and Immunity. 80(4):1333-1342.
Bovine milk exosome proteome -
Reinhardt, T.A., Lippolis, J.D., Nonnecke, B.J., Sacco, R.E. 2012. Bovine milk exosome proteome. Journal of Proteomics. 75(5):1486-1492.
Mechanisms regulating immunity and disease severity following high and low virulence BVDV type 2 infection in neonatal calves -
McGill, J.L., Schaut, R.G., Neill, J.D., Ridpath, J.F., Sacco, R.E. 2011. Mechanisms regulating immunity and disease severity following high and low virulence BVDV type 2 infection in neonatal calves [abstract]. In: Proceedings of the U.S. Bovine Viral Diarrhea Virus Symposium, November 17-18, 2011, San Diego, California. p. 67.
Bovine viral diarrhea virus modulations of monocyte derived macrophages -
Schaut, R.G., McGill, J.L., Neill, J.D., Ridpath, J.F., Sacco, R.E. 2011. Bovine viral diarrhea virus modulations of monocyte derived macrophages [abstract]. In: Proceedings of the U.S. Bovine Viral Diarrhea Virus Symposium, November 17-18, 2011, San Diego, Calfornia. p. 69.
Characterization of viral replication and the immune response in bison peripheral blood mononuclear cells following in vitro bovine viral diarrhea virus infection -
McGill, J.L., Schaut, R.G., Neill, J.D., Olsen, S.C., Ridpath, J.F., Sacco, R.E. 2011. Characterization of viral replication and the immune response in bison peripheral blood mononuclear cells following in vitro bovine viral diarrhea virus infection [abstract]. In: Proceedings of the U.S. Bovine Viral Diarrhea Virus Symposium, November 17-18, 2011, San Diego, California. p. 59.
Treatment of an intramammary bacterial infection with 25-hydroxyvitamin D3 -
Lippolis, J.D., Reinhardt, T.A., Sacco, R.E., Nonnecke, B.J., Nelson, C.D. 2011. Treatment of an intramammary bacterial infection with 25-hydroxyvitamin D3. PLoS One. 6(10):e25479. Available: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184989/pdf/pone.0025479.pdf.
Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature, peripheral blood leukocytes and serum -
Richeson, J.T., Kegley, E.B., Powell, J.G., Galloway, D.L., Hornsby, J.A., Schaut, R.G., Sacco, R.E., Ridpath, J.F. 2012. Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature, peripheral blood leukocytes and serum proinflammatory cytokine and haptoglobin concentrations. Arkansas Animal Science Department Report 2011. AAES Research Series 597. p. 34-39.
Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature, peripheral blood leukocytes and serum -
Richeson, J.T., Kegley, E.B., Powell, R.G., Schaut, R.G., Sacco, R.E., Ridpath, J.F. 2011. Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature, peripheral blood leukocytes and serum proinflammatory cytokine concentrations [abstract]. Joint Annual Meeting American Dairy Science Association-American Society of Animal Science. Journal of Animal Science 89(E-Suppl. 1)/J. Dairy Sci. 94(E-Suppl.1). p. 157. Available: http://www.jtmtg.org/2011/abstracts/0157.PDF.
Porcine TLR3 characterization and expression in response to influenza virus and Bordetella bronchiseptica -
Sacco, R.E., Nicholson, T.L., Waters, T.E., Brockmeier, S. 2011. Porcine TLR3 characterization and expression in response to influenza virus and Bordetella bronchiseptica. Veterinary Immunology and Immunopathology. 142(1-2):57-63.
Neonatal and Adult AMphi Upregulate Cytokine Gene Transcription Via p38 MAPK Signaling in Response to RSV -
Schaut, R., Levy, N., Sacco, R.E. 2010. Neonatal and Adult AMphi Upregulate Cytokine Gene Transcription Via p38 MAPK Signaling in Response to RSV [abstract]. Autumn Immunology Conference. 39:26.
Modeling Bovine Respiratory Syncytial Virus Infection -
Sacco, R.E., Waters, W.R., Palmer, M.V., Nonnecke, B.J. 2010. Modeling Bovine Respiratory Syncytial Virus Infection [abstract]. The Association for Veterinary Teaching and Research Work. p. 6.
Bovine Viral Diarrhea Virus Modulation of Monocyte Derived Macrophage -
Schaut, R.G., Ridpath, J.F., Neill, J.D., Sacco, R.E. 2010. Bovine Viral Diarrhea Virus Modulation of Monocyte Derived Macrophage [abstract]. American Association of Veterinary Laboratory Diagnosticians. p. 241.
Influenza Virus Coinfection with Bordetella bronchiseptica Enhances Bacterial Colonization and Host Responses Exacerbating Pulmonary Lesions Reprint Icon -
Loving, C.L., Brockmeier, S.L., Vincent, A.L., Palmer, M.V., Sacco, R.E., Nicholson, T.L. 2010. Influenza Virus Coinfection with Bordetella bronchiseptica Enhances Bacterial Colonization and Host Responses Exacerbating Pulmonary Lesions. Microbial Pathogenesis. 49(5):237-245.
Differential Expression of Cytokine Transcripts in Neonatal and Adult Ovine Alveolar Macrophages in Response to Respiratory Syncytial Virus or Toll-Like Receptor Ligation -
Fach, S.J., Olivier, A., Gallup, J.M., Waters, T.E., Ackermann, M., Lehmkuhl, H.D., Sacco, R.E. 2010. Differential Expression of Cytokine Transcripts in Neonatal and Adult Ovine Alveolar Macrophages in Response to Respiratory Syncytial Virus or Toll-Like Receptor Ligation. Veterinary Immunology and Immunopathology. 136(1-2):55-64.
Swine influenza virus co-infection with Bordetella bronchiseptica enhances bacterial colonization and host immune responses exacerbating pulmonary lesions -
Loving, C.L., Brockmeier, S.L., Vincent, A.L., Palmer, M.V., Sacco, R.E., Nicholson, T.L. 2010. Swine influenza virus co-infection with Bordetella bronchiseptica enhances bacterial colonization and host immune responses exacerbating pulmonary lesions [abstract]. Conference Research Workers Disease Meeting. Paper No. 130.
Signal Regulatory Protein alpha (SIRPalpha)+ Cells in the Adaptive Response to ESAT-6/CFP-10 Protein of Tuberculous Mycobacteria Reprint Icon -
Waters, W.R., Palmer, M.V., Nonnecke, B.J., Thacker, T.C., Estes, D.M., Larsen, M.H., Jacobs, W.R., Andersen, P., Mcnair, J., Minion, F.C., Lyashchenko, K.P., Hewinson, R.G., Vordermeier, H.M., Sacco, R.E. 2009. Signal Regulatory Protein alpha (SIRPalpha)+ Cells in the Adaptive Response to ESAT-6/CFP-10 Protein of Tuberculous Mycobacteria. PLoS One [serial online]. 4(7):e6414. Available: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006414.
Laser Capture Microdissection Revisited as a Tool for Transcriptomic Analysis: Application of an Excel-Based qPCR Preparation Software (PREXCEL-Q) -
Sow, F.B., Gallup, J.M., Sacco, R.E., Ackermann, M.R. 2009. Laser Capture Microdissection Revisited as a Tool for Transcriptomic Analysis: Application of an Excel-Based qPCR Preparation Software (PREXCEL-Q). International Journal of Biomedical Science. 5(2):105-124.
Adenovirus-Mediated Expression of Interferon-Alpha Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus -
Brockmeier, S., Lager, K.M., Grubman, M.J., Brough, D.E., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Loving, C.L., Vorwald, A.C., Kehrli Jr, M.E., Lehmkuhl, H.D. 2009. Adenovirus-Mediated Expression of Interferon-Alpha Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus. Viral Immunology. 22(3):173-180.
The mononuclear phagocyte system and lymphocytes -
Sacco, R.E. 2009. The Mononuclear Phagocyte System and Lymphocytes. In: Cheville, N.F., editor. Ultrastructural Pathology. 2nd edition. Ames, IA: Wiley Blackwell Press. p. 268-294.
Differences in immune response of pigs challenged with a high versus low dose inoculum of porcine reproductive and respiratory syndrome virus -
Loving, C.L., Brockmeier, S.L., Vincent, A.L., Lager, K.M., Sacco, R.E. 2008. Differences in clinical disease and immune response of pigs challenged with a high-dose versus low-dose inoculum of porcine reproductive and respiratory syndrome virus. Viral Immunology. 21(3):315-325.
Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica -
Brockmeier, S., Vincent, A.L., Loving, C.L., Nicholson, T.L., Sacco, R.E. 2008. Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica. In: Proceedings of the 20th International Pig Veterinary Society Congress, June 22-26, 2008, Durban, South Africa. 1:10.
Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica -
Brockmeier, S., Loving, C.L., Nicholson, T.L., Vincent, A.L., Sacco, R.E. 2008. Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica [abstract]. American Society for Microbiology Meeting, June 2-4, 2008, Boston, Massachusetts. 2008 CDROM.
DNA vaccines against infectious agents: recent strategies for enhancing immune responses -
Sacco, R.E. 2008. DNA vaccines against infectious agents: Recent strategies for enhancing immune responses. Expert Opinion on Therapeutic Patents. 18(4):365-373.
Coinfection of Pigs with Swine Influenza Virus and Bordetella bronchiseptica -
Brockmeier, S., Vincent, A.L., Nicholson, T.L., Sacco, R.E., Palmer, M.V. 2007. Coinfection of Pigs with Swine Influenza Virus and Bordetella bronchiseptica [abstract]. In: United States Japan Natural Resources Animal and Avian Health Panel, December 5, 2007, Tsukuba, Japan. p. 25.
Veterinary Applications for Monitoring Mononuclear Cell Proliferation Using Cell Tracking Dyes -
Waters, W.R., Sacco, R.E. 2007. Veterinary Applications for Monitoring Mononuclear Cell Proliferation Using Cell Tracking Dyes. Immunological Investigations. 36(5-6):887-908.
Immune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene -
Register, K.B., Sacco, R.E., Brockmeier, S. 2007. Immune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene. Vaccine. 25(32):6118-28.
IL-4 induction in RSV-infected macrophages: examining the role of NFAT family members -
Levy, N.A., Fach, S.J., Sacco, R.E. 2007. IL-4 induction in RSV-infected macrophages: examining the role of NFAT family members [abstract]. American Association of Immunologists Proceedings. 178:B128.
Viruses as Predisposing Factors to Bacterial Pneumonia -
Lehmkuhl, H.D., Briggs, R.E., Sacco, R.E., Tatum, F.M. 2007. Viruses as Predisposing Factors to Bacterial Pneumonia [abstract]. Respiratory Disease in Mountain Sheep: Knowledge Gaps and Future Research. p. 154.
Immune Response in Mice and Swine to a DNA Vaccine Derived from the Pasteurella multocida toxin gene -
Register, K.B., Sacco, R.E., Brockmeier, S. 2007. Immune Response in Mice and Swine to a DNA Vaccine Derived from the Pasteurella multocida toxin gene[abstract]. American Society for Microbiology Meeting. May 21-25, 2007, Toronto, Canada. 2007 CD-ROM.
Coinfection with Swine Influenza Virus and Bordetella bronchiseptica in Pigs -
Brockmeier, S., Vincent, A.L., Sacco, R.E., Nicholson, T.L., Palmer, M.V. 2007. Coinfection with Swine Influenza Virus and Bordetella bronchiseptica in Pigs [abstract]. American Society for Microbiology Meeting, May 21-25,2007, Toronto, Canada. 2007 CD-ROM.
INNATE CYTOKINE RESPONSES IN PORCINE MACROPHAGE POPULATIONS: EVIDENCE FOR DIFFERENTIAL RECONGITION OF DSRNA -
Loving, C.L., Brockmeier, S., Wenjun, M., Richt, J., Sacco, R.E. 2006. Innate Cytokine Responses in Porcine Macrophage Populations: Evidence for Differential Recongition of dsRNA. Journal of Immunology. 177:8432-8439.
NEONATAL OVINE PULMONARY DENDRITIC CELLS SUPPORT BRSV REPLICATION WITH ENHANCED IL-4 AND IL-10 GENE TRANSCRIPTS -
Fach, S.J., Meyerholz, D.K., Gallup, J.M., Ackermann, M.R., Lehmkuhl, H.D., Sacco, R.E. 2007. Neonatal Ovine Pulmonary Dendritic Cells Support BRSV Replication with Enhanced IL-4 and IL-10 Gene Transcripts. Viral Immunology. 20(1):119-130.
Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus -
Loving, C.L., Brockmeier, S., Sacco, R.E. 2006. Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus. Immunology. 120:217-229.
Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus -
Brockmeier, S.L., Lager, K.M., Grubman, M.J., Brough, D., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Lehmkuhl, H.D. 2006. Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus. Proceedings of the 87th Conference of Research Workers in Animal Diseases, December 3-5, 2006. Chicago, Illinois. p.124.
Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus -
Brockmeier, S.L., Lager, K.M., Grubman, M.J., Brough, D., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Lehmkuhl, H.D. 2006. Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus. Proceeding of the International PRRS Symposium, December 1-2, 2006, Chicago, Illinois. p. 27.
IMMUNE RESPONSES OF ELK TO INITITAL AND BOOSTER VACCINATIONS WITH BRUCELLA ABORTUS STRAIN RB51 OR 19 -
Olsen, S.C., Fach, S.J., Palmer, M.V., Sacco, R.E., Stoffregen, W.C., Waters, W.R. 2006. Immune Responses of Elk to Initital and Booster Vaccinations with Brucella abortus Strain RB51 or 19. Clinical and Vaccine Immunology. 13(10):1098-1103.
DIFFERENTIAL REGULATION OF TYPE I INTERFERON ACTIVATION IN MACROPHAGES -
Loving, C.L., Brockmeier, S., Sacco, R.E. 2006. Differential regulation of type I interferon activation in macrophages [abstract]. American Association of Immunologists Proceedings. 249:43-44.
PULMONARY DENDRITIC CELLS ISOLATED FROM NEONATAL AND ADULT OVINE LUNG TISSUE -
Fach, S.J., Brockmeier, S., Hobbs, L.A., Lehmkuhl, H.D., Sacco, R.E. 2006. Pulmonary dendritic cells isolated from neonatal and adult ovine lung tissue. Veterinary Immunology and Immunopathology. 112(3-4):171-82.
COMPARATIVE NITRIC OXIDE PRODUCTION OF LPS-STIMULATED MONOCYTE-DERIVED MACROPHAGES FROM OVIS CANADENSIS AND OVIS ARIES -
Sacco, R.E., Waters, W.R., Rudolph, K.M., Drew, M.L. 2006. Comparative nitric oxide production of LPS-stimulated monocyte-derived macrophages from Ovis canadensis and Ovis aries. Comparative Immunology Microbiology and Infectious Diseases. 29(1):1-11.
NEONATAL LAMB RESPIRATORY TRACT DENDRITIC CELLS AND THE EFFECTS OF RSV INFECTION -
Fach, S.J., Meyerholz, D.K., Gallup, J.M., Ackermann, M.R., Lehmkuhl, H.D., Sacco, R.E. 2005. Neonatal lamb respiratory tract dendritic cells and the effects of RSV infection [abstract]. Federation of American Societies for Experimental Biology Conference. 19:A403.
PRRS VIRUS PRODUCTIVELY INFECTS MONOCYTE-DERIVED DENDRITIC CELLS AND INDUCES PRODUCTION OF INNATE ANTIVIRAL MEDIATORS -
Loving, C.L., Brockmeier, S., Sacco, R.E. 2005. Prrs virus productively infects monocyte-derived dendritic cells and induces production of innate antiviral mediators. Federation of American Societies for Experimental Biology Conference. 19:A404.
EFFECT OF BRSV INFECTION IN NEONATAL LAMBS ON RESPIRATORY TRACT DENDRITIC CELLS -
Fach, S.J., Meyerholz, D.K., Gallup, J.M., Ackermann, M.R., Lehmkuhl, H.D., Sacco, R.E. 2004. Effect of BRSV infection in neonatal lambs on respiratory tract dendritic cells [abstract]. Autumn Immunology Conference. p. 52.
INNATE IMMUNITY OF RESPIRATORY EPITHELIA: EFFECTS OF PRETERM BIRTH AND RESPIRATORY SYNCYTIAL VIRUS INFECTION -
Ackermann, M.R., Meyerholz, D.K., Grubor, B., Lehmkuhl, H.D., Sacco, R.E., Gallup, J.M., Derscheid, R., Lazic, T., Fach, S., Kawashima, K. 2004. Innate immunity of respiratory epithelia: effects of preterm birth and respiratory syncytial virus infection [abstract]. Conference of Research Workers in Animal Diseases. p. 136.
INCREASED SEVERITY OF BOVINE RESPIRATORY SYNCYTIAL VIRUS INFECTION IN PRETERM LAMBS -
Meyerholz, D.K., Grubor, B., Fach, S.J., Sacco, R.E., Lehmkuhl, H.D., Gallup, J.M., Ackermann, M.R. 2004. Increased severity of bovine respiratory syncytial virus infection in preterm lambs [abstract]. Bi-Annual All-Iowa Virology Symposium. Paper No. 12.
COMPARISON OF THE EXPRESSED PORCINE VBETA AND JBETA REPERTOIRE OF THYMOCYTES AND PERIPHERAL T-CELLS -
Butler, J.E., Wertz, N., Sun, J., Sacco, R.E. 2005. Comparison of the expressed porcine vbeta and jbeta repertoire of thymocytes and peripheral t-cells. Immunology. 114:184-193.
REDUCED CLEARANCE OF RESPIRATORY SYNCYTIAL VIRUS IN A PRETERM LAMB MODEL -
Meyerholz, D.K., Grubor, B., Fach, S.J., Sacco, R.E., Lehmkuhl, H.D., Gallup, J.M., Ackermann, M.R. 2004. Reduced clearance of respiratory syncytial virus in a preterm lamb model. Microbes and Infection. 6(14):1312-1319.
IMMUNE RESPONSE TO A DNA VACCINE DERIVED FROM THE PASTEURELLA MULTOCIDA TOXIN GENE -
Register, K.B., Sacco, R.E., Brockmeier, S. 2004. Immune response to a dna vaccine derived from the pasteurella multocida toxin gene. Pig Veterinary Society International Congress Proceedings. p. 200.
RESPIRATORY SYNCYTIAL VIRUS INFECTION IN PRETERM LAMBS -
Meyerholz, D.K., Grubor, B., Fach, S.J., Sacco, R.E., Ensley, D., Lehmkuhl, H.D., Gallup, J.M., Ackermann, M.R. Respiratory syncytial virus infection in preterm lambs. 2004. Presented at FASEB Meeting. Abstract No. 1074.
THE EFFECTS OF PASTEURELLA MULTOCIDA TOXIN (PMT) ON EARLY MURINE B-LINEAGE CELLS -
Loving, C.L., Sacco, R.E. 2003. The effects of pasteurella multocida toxin (pmt) on early murine b-lineage cells. Autumn Immunology Conference Proceedings. Abstract No. 140, p. 54.
THE EFFECTS OF PASTEURELLA MULTOCIDA TOXIN (PMT) ON EARLY MURINE B-LINEAGE CELLS -
Loving, C.L., Sacco, R.E. 2003. The effects of Pasteurella multocida toxin (pmt) on early murine b-lineage cells. Immunology Research Workshop. December 2, 2003.
ANALYSIS OF LYMPHOCYTES ISOLATED FROM WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) FAWNS -
Fach, S.J., Waters, W.R., Palmer, M.V., Davis, W.C., Sacco, R.E. 2003. Analysis of lymphocytes isolated from white-tailed deer (odocoileus virginianus) fawns. Immunology Research Workshop. December 2, 2003.
RE-EMERGENCE OF BORDETELLA BRONCHISPETICA DURING THE RECENT SEAL MORBILLIVIRUS OUTBREAK -
FOSTER, G., REGISTER, K.B., SACCO, R.E., PATTERSON, I.P. RE-EMERGENCE OF BORDETELLA BRONCHISPETICA DURING THE RECENT SEAL MORBILLIVIRUS OUTBREAK. PROCEEDINGS OF THE SCOTTISH AGRICULTURAL COLLEGE OF VETERINARY SCIENCES CONFERENCE. SEPTEMBER 10-11, 2003. p. 21.
DEFENSIN-INDUCED ADAPTIVE IMMUNITY IN MICE AND ITS POTENTIAL IN PREVENTING PERIODONTAL DISEASE -
Brogden, K.A., Heidari, M., Sacco, R.E., Palmquist, D.E., Guthmiller, J.M., Johnson, G.K., Jia, H.P., Tack, B.F., Mccray, P.B. 2003. Defensin-induced adaptive immunity in mice and its potential in preventing periodontal disease. Oral Microbiology and Immunology. Vol. 18:95-99.
COMPARISON BETWEEN RIBOTYPING AND RESTRICTION ENZYME ANALYSIS FOR INTER- AND INTRASPECIES DISCRIMINATION OF BORDETELLA AVIUM AND BORDETELLA HINZII -
REGISTER, K.B., SACCO, R.E., NORDHOLM, G.E. COMPARISON OF RIBOTYPING AND RESTRICTION ENZYME ANALYSIS FOR INTER- AND INTRASPECIES DISCRIMINATION OF BORDETELLA AVIUM AND BORDETELLA HINZII. JOURNAL OF CLINICAL MICROBIOLOGY. 2003. v. 41(4). p. 1512-1519.
IMMUNE RESPONSES OF ELK TO MYCOBACTERIUM BOVIS BACILLUS CALMETTE GUERIN VACCINATION -
Waters, W.R., Palmer, M.V., Olsen, S.C., Sacco, R.E., Whipple, D.L. 2003. Immune responses of elk to mycobacterium bovis bacillus calmette guerin vaccination. Vaccine. Vol. 21(13-14), p. 1518-1526.
DEFENSIN INDUCED ADAPTIVE IMMUNITY IN MICE AND ITS POTENTIAL IN PREVENTING PERIODONTAL DISEASE -
BROGDEN, K.A., HEIDARI, M., SACCO, R.E., PALMQUIST, D.E., GUTHMILLER, J.M., JOHNSON, G.K., JIA, H.P., TACK, B.F., MCCRAY, JR., P.B. DEFENSIN-INDUCED ADAPTIVE IMMUNITY IN MICE AND ITS POTENTIAL IN PREVENTING PERIODONTAL DISEASE. ORAL MICROBIOLOGY AND IMMUNOLOGY. 2003. v. 18. p. 95-99.
ANALYSIS OF LYMPHOCYTES ISOLATED FROM WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) FAWNS -
BHUR, A VIRULENCE-ASSOCIATED OUTER MEMBRANE PROTEIN OF BORDETELLA AVIUM, IS REQUIRED FOR THE ACQUISITION OF IRON FROM HEME AND HEMOPROTEINS -
MURPHY, E.R., SACCO, R.E., DICKENSON, A., METZGER, D.J., HU, Y., ORNDORFF, P.E., CONNELL, T.D. BHUR, A VIRULENCE-ASSOCIATED OUTER MEMBRANE PROTEIN OF BORDETELLA AVIUM, IS REQUIRED FOR THE ACQUISITION OF IRON FROM HEME AND HEMOPROTEINS. INFECTION AND IMMUNITY. 2002. v. 70(10). p. 5390-5403.
INDUCTION OF TH2-LIKE IMMUNE RESPONSES BY C3H MICE BEARING A DEFINED FLORA FOLLOWING ONSET OF COLITIS -
ESTABLISHED TH1 GRANULOMATOUS RESPONSES INDUCED BY ACTIVE MYCOBACTERIUM AVIUM INFECTION SWITCH TO TH2 FOLLOWING CHALLENGE WITH SCHISTOSOMA MANSONI -
SACCO, R.E., HAGEN, M., SANDOR, M., WEINSTOCK, J.V., LYNCH, R.G. ESTABLISHED TH1 GRANULOMATOUS RESPONSES INDUCED BY ACTIVE MYCOBACTERIUM AVIUM INFECTION SWITCH TO TH2 FOLLOWING CHALLENGE WITH SCHISTOSOMA MANSONI. Clinical Immunology. 2002. v. 104(3). p. 274-281.
ANALYSIS OF MITOGEN-STIMULATED LYMPHOCYTE SUBSET PROLIFERATION AND NITRIC OXIDE PRODUCTION BY PERIPHERAL BLOOD MONONUCLEAR CELLS OF CAPTIVE ELK (CERVUS ELAPHUS) -
NITRIC OXIDE PRODUCTION AS AN INDICATION OF MYCOBACTERIUM BOVIS INFECTION OF WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) -
NITRIC OXIDE PRODUCTION AS AN INDICATION OF MYCOBACTERIUM BOVIS INFECTION OF WHITE-TAILED DEER -
CHARACTERIZATION OF BIGHORN SHEEP (OVIS CANADENSIS) MACROPHAGES USING IMMUNOHISTOCHEMICAL, FLOW CYTOMETRIC AND FUNCTIONAL ASSAYS (POSTER PRESENTATION FOR THE 82ND CONFERENCE OF RESEARCH WORKERS IN ANIMAL DISEASE) -
PHENOTYPIC ANALYSIS OF LYMPHOCYTES ISOLATED FROM WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) FAWNS USING THREE-COLOR FLOW CYTOMETRY (POSTER PRESENTATION AT THE 82ND CONFERENCE OF RESEARCH WORKERS IN ANIMAL DISEASE) -
BETA DEFENSIN-INDUCED ADAPTIVE IMMUNE RESPONSE TO OVALBUMIN IN MICE (POSTER PRESENTATION FOR THE 101ST ASM ANNUAL MEETING, MAY 20-24, 2001) -
IDENTIFICATION OF NEW MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN A CLOSED EXPERIMENTAL LINE OF BELTSVILLE SMALL WHITE TURKEYS -
GALLINACIN-3, AN INDUCIBLE EPITHELIAL BETA DEFENSIN OF THE CHICKEN -
RESTRICTION ENDONUCLEASE ANALYSIS DISCRIMNATES BORDETELLA BRONCHISEPTICA ISOLATES -
FLOW CYTOMETRIC ANALYSIS OF COLONIC AND SMALL INTESTINAL MUCOSAL LYMPHOCYTES OBTAINED BY ENDOSCOPIC BIOPSY IN THE HEALTHY DOG -
ANTIGEN-SPECIFIC PROLIFERATION OF PORCINE CD8 ALPHA ALPHA CELLS TO AN EXTRACELLULAR BACTERIAL PATHOGEN -
REDUCTION IN INFLAMMATION FOLLOWING BLOCKADE OF CD18 OR CD29 ADHESIVE PATHWAYS DURING THE ACUTE PHASE OF A SPIROCHETAL-INDUCED COLITIS IN MICE -
RIBOTYPING AND RESTRICTION ENDONUCLEASE ANALYSIS REVEAL A NOVEL CLONE OF BORDETELLA BRONCHISEPTICA IN SEALS -
B CELLS ARE REQUIRED FOR THE INDUCTION OF INTESTINAL INFLAMMATORY LESIONS IN TCR ALPHA-DEFICIENT MICE PERSISTENTLY INFECTED WITH CRYPTOSPORIDIUM PARVUM -
RESTRICTION ENZYME ANALYSIS OF BORDETELLA BRONCHISPETICA ISOLATES -
BORDETELLA AVIUM DERMONECROTIC TOXIN INDUCES APOPTOSIS IN LYMPHOID TISSUES -
ANTIGEN-SPECIFIC PROLIFERATION OF PORCINE CD8 ALPHA ALPHA T CELLS -
POULT NEPHROPATHY INDUCED BY A BORDETELLA AVIUM TOXIN -
RESTRICTION ENZYME ANALYSIS AND RIBOTYPING DISTINGUISH BORDETELLA AVIUM AND BORDETELLA HINZII ISOLATES -
GENETIC VARIATION IN RESPONSE OF TURKEYS TO EXPERIMENTAL INFECTION WITH BORDETELLA AVIUM (RESEARCH NOTE) -
BORDETELLA AVIUM DERMONECROTIC TOXIN CAUSES LYMPHOID LESIONS IN MICE (ORAL PRESENTATION FOR THE AVMA/AAAP MTG., JULY 1999) -
CELLULAR IMMUNE RESPONSES OF PIGS INDUCED BY VACCINATION WITH EITHER A WHOLE CELL SONICATE OR PEPSIN-DIGESTED SERPULINA HYODYSENTERIAE BACTERIN -
CRYPTOSPORIDIUM PARVUM-INDUCED INFLAMMATORY BOWEL DISEASE OF TCR-BETA X TCR-DELTA-DEFICIENT MICE -
SYSTEMIC AND MUCOSAL IMMUNE RESPONSES OF PIGS TO PARENTERAL IMMUNIZATION WITH A PEPSIN-DIGESTED SERPULINA HYODYSENTERIAE BACTERIN -
MODULATION OF THE LYMPHOCYTE REPERTOIRE IN MICE FOLLOWING ADMINISTRATION OF BORDETELLA AVIUM DERMONECROTIC TOXIN (POSTER PRESENTATION FOR THE 99TH ASM GEN. MEETING, MAY 30 - JUNE 3, 1999) -
ROLE OF ACUTE PHASE CYTOKINES AND LEUKOCYTIC INFILTRATION IN A MURINE MODEL OF SPIROCHETE-INDUCED COLITIS (POSTER PRESENTATION AT THE KEYSTONE SYMPOSIA, SANTA FE, NM, JANUARY 1999) -
ANTIGEN-SPECIFIC B CELL UNRESPONSIVENESS INDUCED BY CHRONIC MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS INFECTION IN CATTLE -
ANTIGEN-SPECIFIC B CELL UNRESPONSIVENESS INDUCED BY CHRONIC MYCOBACTERIUM AVIUM SUBSP PARATUBERCULOSIS INFECTION OF CATTLE -
UTILITY OF DNA FINGERPRINTING TO DISTINGUISH BORDETELLA AVIUM, BORDETELLA HINZII AND ALCALIGENES FAECALIS ISOLATES (ORAL PRESENTATION FOR THE 33RD UNITED STATES-JAPAN NATURAL RESOURCES MYCOPLASMOSIS MTG. (UJNR) -
USE OF PKH2 TO DEMONSTRATE ANTIGEN-SPECIFIC B CELL UNRESPONSIVENESS IN CATTLE CHRONICALLY INFECTED WITH MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS -
CELLULAR IMMUNE RESPONSES OF PIGS TO PARENTERAL VACCINATION WITH A SERPULINA HYODYSENTERIAE WHOLE CELL SONICATE OR PEPSIN-DIGEST BACTERIN -
DNA FINGERPRINTING OF BORDETELLA AVIUM AND BORDETELLA HINZII ISOLATES -
CRYPTOSPORIDIUM PARVUM INITIATES INFLAMMATORY BOWEL DISEASE IN GERMFREE T CELL RECEPTOR-ALPHA-DEFICIENT MICE -
FLOW CYTOMETRIC ANALYSIS OF CANINE COLONIC MUCOSAL LYMPHOCYTES OBTAINED FROM ENDOSCOPIC BIOPSIES -
SUSCEPTIBILITY OF CONVALESCENT TURKEYS TO PULMONARY ASPERGILLOSIS (RESEARCH NOTE) -
INFECTION WITH CRYPTOSPORIDIUM PARVUM INITIATES INFLAMMATORY BOWEL DISEASE IN GERM-FREE TCR-ALPHA-DEFICIENT MICE -
Last Modified: 5/2/2016
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