Author
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Mastovska, Katerina |
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Submitted to: Analytical Chemistry
Publication Type: Review Article Publication Acceptance Date: 6/2/2007 Publication Date: 1/5/2008 Citation: Mastovska, K. 2008. Recent development in chromatographic techniques. Analytical Chemistry.51:175-200 Interpretive Summary: Technical Abstract: Chromatographic techniques play a significant role in the determination of analytes in complex matrices, separating individual sample components prior to their detection. In the analysis of contaminants and chemical residues in foods, gas chromatography (GC) and liquid chromatography (LC) are two main chromatographic methods employed in practice. In the past, the well-established conjunction of GC with mass spectrometric (MS) detection and availability of relatively affordable bench-top GC-MS instruments, made GC a number one choice for multi-component contaminant and residue analysis, even though the polar analytes had to be derivatized prior to the GC step. In recent years, the situation has dramatically changed thanks to the advances in LC-MS, which brought this powerful technique to routine laboratories and opened the door to direct, selective and sensitive analysis of polar compounds. The increasing availability, affordability, and performance of GC-MS and LC-MS instruments have led to a growing interest in fast GC and LC separations in recent years. Also, fast separation and detection play an important role in two-dimensional (2D) separations, particularly in comprehensive 2D chromatography. This article discusses recent developments in fast and 2D chromatographic techniques and their application in the GC and LC analysis of contaminants and chemical residues in foods. Furthermore, it also reviews current and some novel approaches to overcome matrix effects that may adversely affect quantitative GC and LC-MS analysis of trace components in food matrices. |
