Submitted to: Archives of Virology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/7/1999
Publication Date: N/A
Citation: Bonneau, K.R., Zhang, N.Z., Wilson, W.C., Zhu, J.B., Zhang, F.Q., Li, K.L., Zhang, K.L., Xiao, L., Xiang, W.B., Maclachlan, N.J. 2000. Phylogenetic analysis of the s7 gene does not segregate chinese strains of bluetongue virus into a single topotype. Archives of Virology. (2000) 145:1163-1171
Interpretive Summary: This paper compares the genet sequence of bluetongue viruses from China, US. Australia and South Africa for one gene that encodes an inner core virus protein. There was no genetic segregation based on geographic origin.
Technical Abstract: Bluetongue virus (BTV) infection of ruminants is endemic throughout tropical and subtropical regions of the world. The S7 gene segments of prototype Chinese strains of BTV serotypes 1, 2, 3, 4, 12, 15, and 16 were sequenced and compared to the same genes of prototype strains of BTV from the US, Australia, and South Africa. The S7 genes and predicted VP7 proteins of the Chinese viruses were relatively conserved, with the notable exception of serotype 15. Furthermore, phylogenetic analysis of the S7 genes did not predict geographic origin of the various strains of BTV.