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Title: INFLUENCE OF IGF-I TRANSGENE AND DIETARY CLA ON EFFICIENCY OF DIETARY ENERGY AND PROTEIN UTILIZATION IN GROWING PIGS

Author
item Mitchell, Alva
item PURSEL, V. - ARS, RETIRED, GEML

Submitted to: Energy Metabolism of Farm Animals Symposium Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 6/1/2003
Publication Date: 9/1/2003
Citation: Mitchell, A.D., Pursel, V.G. 2003. Efficiency of energy deposition and body composition of control and IGF-I transgenic pigs. In: Progress in Research on Energy and Protein Metabolism. (W.B. Souffrant and C.C. Metges, Eds.), EAAP Scientific Series. v 109:61-64.

Interpretive Summary: Conjugated linoleic acid (CLA), when added to the diets of pigs reduces fat deposition and increases lean tissue mass. Pigs expressing the skeletal a-actin-hIGF-I transgene have been shown to deposit less fat and more lean than their littermate controls. The efficiency of nutrient utilization represents an important economic factor in swine production. Thus, the objective of this study was to measure the efficiency of energy and protein accretion in control and IGF transgenic pigs when fed diets with or without CLA added. These results of this study demonstrate that the addition of CLA to the diet reduces the efficiency of energy deposition, however, inclusion of the IGF-I transgene into the genetic makeup improves the efficiency of protein deposition in pigs.

Technical Abstract: The purpose of this study was to compare the efficiency of utilization of dietary energy and protein by control and IGF-I transgenic pigs in response to dietary conjugated linoleic acid (CLA). At 60 kg each pig was scanned by dual-energy X-ray absorptiometry (DXA) for body composition analysis, then placed on a diets with a CP content of 182 g·kg-1, a ME content of 13.8 MJ·kg-1, and supplemented with either corn oil at 20 g·kg-1 (CO diet) or CO at 10 g·kg-1 plus CLA at 10 g·kg-1 (CLA diet). Each pig was scanned again by DXA at 110 kg. Total body fat and protein deposition were based on the differences between the 60-kg and 110-kg DXA measurements of fat and lean. The efficiency of energy (kg) deposition was higher (P<0.05) for the C-CO pigs compared to the C-CLA or T-CLA pigs, while the T-C pigs were intermediate. The kg was higher (P<0.05) for pigs fed the CO diet compared to those fed the CLA diet. There was no difference in kg based on genotype or sex. The efficiency of protein (PE) deposition was higher (P<0.05) in the T-CO and T-CLA pigs compared to the C-CO and C-CLA pigs; hence there was a significant genotype effect. There was also a significant sex effect (females > barrows), but no diet effect. These results demonstrate that the addition of CLA to the diet reduces the efficiency of energy deposition, however, inclusion of the IGF-I transgene into the genetic makeup improves the efficiency of protein deposition in pigs.