|Van Eerd, Laura|
Submitted to: Weed Science
Publication Type: Review Article
Publication Acceptance Date: 2/12/2002
Publication Date: 6/10/2002
Citation: Van Eerd, L.L., Hoagland, R.E., Zablotowicz, R.M., Hall, J.C. 2002. Pesticide metabolism in plants and microorganisms. Weed Science 51:472-495. Interpretive Summary:
Technical Abstract: Understanding pesticide metabolism in plants and microorganisms is necessary for pesticide development, safe and efficient use, as well as for developing pesticide bioremediation strategies for contaminated soil and water. Pesticide biotransformation may occur via multi-step processes known as metabolism or co-metabolism. In microorganisms, co-metabolism is the biotransformation of an organic compound that is not used as an energy source, or as a constitutive element of the organism. Individual reactions of degradation/ detoxification pathways include: oxidation, reduction, hydrolysis, and conjugation. Metabolic pathway diversity depends on the chemical structure of the xenobiotic compound, the organism, environmental conditions, metabolic factors, and the regulating expression of these biochemical pathways. Knowledge of these enzymatic processes, especially concepts related to pesticide mechanism of action, resistance, selectivity, tolerance and environmental fate has advanced our understanding of both pesticide science as well as plant/microbial biochemistry and physiology. There are some fundamental similarities and difference between plant and microbial pesticide metabolism. In this review directed to researchers in weed science, we present concepts that were discussed at an American Chemical Society (ACS) Symposium in 1999, and the subsequent book "Pesticide Biotransformation in Plants and Microorganism: Similarities and Divergences", edited by J.C. Hall, R.E. Hoagland, and R.M. Zablotowicz, and published by Oxford University Press.