Submitted to: American Chemical Society Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: 8/20/2000
Publication Date: N/A
Technical Abstract: Conjugated linoleic acid (CLA; 9c,11t-18:2), present in dairy products and beef, has been shown, in animals, to have anticarcinogenic, growth-promoting, antiatherogenic, and lean body mass-enhancing properties. Commercial production of CLA by the base-catalyzed isomerization of linoleic acid yields a mixture of isomers. Pure samples of CLA have been prepared commercially by the dehydration of ricinoleic acid and by the microbial conversion of linoleic acid. Over the last decade, a number of multi-step chemical syntheses have also been developed for preparing highly-pure non-labeled and 2H- and 3H-labeled CLA isomers. The continuing development of physical, chromatographic and biochemical methods for isolation and purification of CLA isomers has resulted in the commercial availability of increasing numbers of highly-pure, conjugated fatty acid isomers, both labeled and unlabeled. Chemical and biological methods for preparing 11C-, 13C- and 14C-labeled CLA will also be discussed, as will the isolation of conjugated fatty acid isomers from seed oils sources.