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ARS Home » Northeast Area » Beltsville, Maryland (BHNRC) » Beltsville Human Nutrition Research Center » Diet, Genomics and Immunology Laboratory » Research » Research Project #426494

Research Project: Regulatory Mechanisms Induced by Health-Promoting Bioactive Food Components on Sex Steroid Hormone-Dependent Pathways, Cancer Cell-Stromal Cell Interactions, and the Gut Microbiome

Location: Diet, Genomics and Immunology Laboratory

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Plant miRNAs in food alter gut microbiota in a rodent model - (Peer Reviewed Journal)

Modulation of CXC-motif chemokine receptor 7, but not 4 expression, is related to migration of the human prostate cancer cell LNCaP: regulation by androgen and inflammatory stimuli Reprint Icon - (Peer Reviewed Journal)
Yu, L., Pham, Q., Yu, L., Wang, T.T. 2019. Modulation of CXC-motif chemokine receptor 7, but not 4 expression, is related to migration of the human prostate cancer cell LNCaP: regulation by androgen and inflammatory stimuli. Inflammation Research. 69, 167-178. https://doi.org/10.1007/s00011-019-01305-0.

Resveratrol differentially modulates immune responses in human THP-1 monocytes and macrophages Reprint Icon - (Peer Reviewed Journal)
Feng, L., Yasmeen, R., Schoene, N., Lei, K.Y., Wang, T.T. 2019. Resveratrol differentially modulates immune responses in human THP-1 monocytes and macrophages. Nutrition Research. 72:57-69. https://doi.org/10.1016/j.nutres.2019.10.003.

The p53 mutation-site in prostate cancer determines its sensitivity to phenethyl isothiocyanate induced growth inhibition Reprint Icon - (Peer Reviewed Journal)
Aggarwal, M., Saxena, R., Asif, N., Sinclair, E., Tan, J., Cruz, I., Berry, D., Kallakury, B., Pham, Q., Wang, T.T., Fung-Lung, C. 2019. The p53 mutation-site in prostate cancer determines its sensitivity to phenethyl isothiocyanate induced growth inhibition. Journal of Experimental and Clinical Cancer Research. 38(1):307. https://doi.org/10.1186/s13046-019-1267-z.

Interactions between food and gut microbiota: Impact on human health Reprint Icon - (Review Article)
Wu, Y., Wan, J., Choe, U., Pham, Q., Schoene, N., He, Q., Li, B., Yu, L., Wang, T.T. 2019. Interactions between food and gut microbiota: Impact on human health. Annual Review of Food Science & Technology. 10:389-408. https://doi.org/10.1146/annurev-food-032818-121303.

Selected lipid-based transfection reagents activate NF-kB and MAP kinases signaling pathways, induced cytokines mRNA expression in human THP-1 macrophage Reprint Icon - (Peer Reviewed Journal)
Choe, U., Yu, L., Wang, T.T. 2019. Selected lipid-based transfection reagents activate NF-kB and MAP kinases signaling pathways, induced cytokines mRNA expression in human THP-1 macrophage. Analytical Biochemistry: Methods in the Biological Sciences. 573:73-76. https://doi.org/10.1016/j.ab.2019.02.018.

Inhibition of tumor growth by indole-3-carbinol in a prostate cancer xenograft model may be associated with disrupted gut microbial interactions Reprint Icon - (Peer Reviewed Journal)
Wu, Y., Li, R.W., Huang, H., Fletcher, A., Yu, L., Pham, Q., Yu, L., He, Q., Wang, T.T. 2019. Inhibition of tumor growth by indole-3-carbinol in a prostate cancer xenograft model may be associated with disrupted gut microbial interactions. Nutrients. 11(2). pii.E467. https://doi.org/10.3390/nu11020467.

The science behind microgreens as an exciting new food for the 21st century Reprint Icon - (Review Article)
Choe, U., Yu, L., Wang, T.T.Y. 2018. The science behind microgreens as an exciting new food for the 21st century. Journal of Agricultural and Food Chemistry. 7:66(44). https://doi.org/10.1021/acs.jafc.8b03096.

Chemical compositions of cold-pressed broccoli, carrot and cucumber seed flours, and their in vitro gut microbiota modulatory, anti-inflammatory and free radical scavenging properties Reprint Icon - (Peer Reviewed Journal)
Choe, U., Li, Y., Gao, B., Yu, L., Wang, T.T., Sun, J., Chen, P., Liu, J., Yu, L. 2018. Chemical compositions of cold-pressed broccoli, carrot and cucumber seed flours, and their in vitro gut microbiota modulatory, anti-inflammatory and free radical scavenging properties. Journal of Agricultural and Food Chemistry. 66(35):9309-0317. https://doi.org/10.1021/acs.jafc.8b03343.

Suppression of T lymphocyte activation by 3-chloro-1,2-propanediol mono- and di-palmitate esters in vitro Reprint Icon - (Peer Reviewed Journal)
Huang, G., Xue, J., Sun, X., Wang, J., Wang, Y., Wang, T.T., Yu, L. 2018. Suppression of T lymphocyte activation by 3-chloro-1,2-propanediol mono- and di-palmitate esters in vitro. Toxicology In Vitro. 51:54-62. https://doi.org/10.1016/j.tiv.2018.05.002.

Microbiota and dose-response: evolving paradigm of health triangle Reprint Icon - (Peer Reviewed Journal)
Coleman, M., Elkins, C.A., Gutting, B.W., Mongodin, E.F., Solano Aguilar, G., Walls, I. 2018. Microbiota and dose-response: evolving paradigm of health triangle. Risk Analysis. 10.1111. https://doi.org/10.1111/risa.13121.

Extensive degradation and low bioavailability of orally consumed corn miRNAs in mice Reprint Icon - (Peer Reviewed Journal)
Huang, H., Davis, C., Wang, T.T. 2018. Extensive degradation and low bioavailability of orally consumed corn miRNAs in mice. Nutrients. 10(2)pii: E215. https://doi.org/10.3390/nu10020215.

The effect of feeding cocoa powder and Lactobacillus rhamnosus LGG on the composition and function of the intestinal microbiome Reprint Icon - (Peer Reviewed Journal)
Solano Aguilar, G., Lakshman, S., Jang, S., Beshah, E., Xie, Y., Sikaroodi, M., Gupta, R., Vinyard, B.T., Molokin, A., Urban Jr, J.F., Gillevet, P., Davis, C. 2018. The effect of feeding cocoa powder and Lactobacillus rhamnosus LGG on the composition and function of the intestinal microbiome. Current Developments in Nutrition. (2)5. https://doi.org/10.1093/cdn/nzy011.

Elucidating the role of CD84 and AHR in modulation of LPS-induced cytokines production by cruciferous vegetable-derived compounds indole-3-carbinol and 3,3'-diindolylmethane Reprint Icon - (Peer Reviewed Journal)
Wang, T.T., Pham, Q., Kim, Y.S. 2018. Elucidating the role of CD84 and AHR in modulation of LPS-induced cytokines production by cruciferous vegetable-derived compounds indole-3-carbinol and 3,3'-diindolylmethane. International Journal of Molecular Sciences. 19(2):pii:E339. https://doi.org/10.3390/ijms19020339.

Home food preparation techniques impacted the availability of natural antioxidants and bioactivities in kale and broccoli Reprint Icon - (Peer Reviewed Journal)
Yu, L., Gao, B., Li, Y., Wang, T.T., Luo, Y., Wang, J., Yu, L. 2018. Home food preparation techniques impacted the availability of natural antioxidants and bioactivities in kale and broccoli. Food & Function. 9(1):585-593. https://doi.org/10.1039/c7fo00948h.

Gypenosides reduced the risk of overweight and insulin resistance in C57BL/6J mice through modulating adipose thermogenesis and gut microbiota Reprint Icon - (Peer Reviewed Journal)
Liu, Jie, Li, Y., Yang, P., Wan, J., Chang, Q., Wang, T.T., Lu, W., Zhang, Y., Wang, Q., Yu, L. 2017. Gypenosides reduced the risk of overweight and insulin resistance in C57BL/6J mice through modulating adipose thermogenesis and gut microbiota. Journal of Agricultural and Food Chemistry. 65(42):9237-9246. https://doi.org/10.1021/acs.jafc.7b03382.

Gypenosides reduced the risk of overweight and insulin resistance in C57BL/6J mice through modulating adipose thermagenesis and gut microbiota Reprint Icon - (Peer Reviewed Journal)
Liu, J., Li, Y., Yang, P., Wan, J., Zhang, Y., Gao, B., Wang, Z., Wang, T.T., Yu, L. 2017. Gypenosides reduced the risk of overweight and insulin resistance in C57BL/6J mice through modulating adipose thermagenesis and gut microbiota. Journal of Food Science and Nutrition. 65(42)9237-9246. https://doi.org/doi: 10.1021/acs.jafc.7b03382.

Lactobacillus rhamnosus LGG and flavanol-enriched cocoa powder altered the immune response to infection with the parasitic nematode Ascaris suum Reprint Icon - (Peer Reviewed Journal)
Jang, S., Lakshman, S., Beshah, E., Xie, Yue, Molokin, A., Vinyard, B.T., Urban Jr, J.F., Davis, C., Solano Aguilar, G. 2017. Lactobacillus rhamnosus LGG and flavanol-enriched cocoa powder altered the immune response to infection with the parasitic nematode Ascaris suum. Nutrients. pii: 1113. https://doi.org/10.3390/nu9101113.

Transcriptional and translational-uncoupling in regulation of the CXCL12 and its receptors CXCR4, 7 in THP-1 monocytes and macrophages Reprint Icon - (Peer Reviewed Journal)
Yu, L., Pham, Q., Yu, L., Wang, T.T. 2018. Transcriptional and translational disconnect in regulation of the CXCL12 and its receptors CXCR4, 7 in THP-1 monocytes and macrophages. Immunity, Inflammation and Disease Journal. 6(1):106-116. https://doi.org/10.1002/iid3.199.

Dose-dependent responses of I3C and DIM on T-cell activation in the human T lymphocyte Jurkat cell line Reprint Icon - (Peer Reviewed Journal)
Liu, M., Yasmeen, R., Fukagawa, N.K., Yu, L., Kim, Y.S., Wang, T.T. 2017. Dose-dependent responses of I3C and DIM on T-cell activation in the human T lymphocyte Jurkat cell line. International Journal of Molecular Sciences. 18(7). pii: E1409. https://doi.org/10.3390/ijms18071409.

Inhibitory effect of piceatannol on TNF-a mediated inflammation and insulin resistance in 3T3-L1 adipocytes Reprint Icon - (Peer Reviewed Journal)
Li, Y., Yang, P., Chang, Q., Wang, J., Liu, J., Yuan, L., Wang, T.T., Gao, B., Yu, L. 2017. Inhibitory effect of piceatannol on TNF-a mediated inflammation and insulin resistance in 3T3-L1 adipocytes. Journal of Agricultural and Food Chemistry. 65(23). https://doi.org/10.1021/acs.jafc.7b01567.

An improved method to quantitate mature plant microRNA in biological matrices using periodate treatment and internal control - (Peer Reviewed Journal)
Huang, H, Roh, J., Davis, C., Wang, T.T. 2017. An improved method to quantitate mature plant microRNA in biological matrices using periodate treatment and internal control. PLoS One. 12(4):e0175429. doi: 10.1371/journal.pone.0175429.

Absorption, distribution, metabolism and excretion of 3-MCPD 1-monopalmitate after oral administration in rats Reprint Icon - (Peer Reviewed Journal)
Gao, B., Liu, M., Huang, G., Zhang, Z., Zhao, Y., Wang, T.T., Zhang, Y., Liu, J., Yu, L. 2018. Absorption, distribution, metabolism and excretion of 3-MCPD 1-monopalmitate after oral administration in rats. Journal of Agricultural and Food Chemistry. 65(12):2609-2614. https://doi.org/10.1021/acs.jafc.7b00639.

Home-based preparation approaches altered the availability of health beneficial components from carrot and blueberry Reprint Icon - (Peer Reviewed Journal)
Gao, B., Yu, L., Liu, J., Wang, T.T., Luo, Y., Yu, L., Zhang, H., Gong, L. 2017. Home-based preparation approaches altered the availability of health beneficial components from carrot and blueberry. Journal of Food Science and Nutrition. (42):9237-9246. https://doi.org/10.1002/fsn3.462.

Establishing health benefits of bioactive food components: a basic research scientist's perspective - (Review Article)
Yasmeen, R., Fukagawa, N.K., Wang, T.T. 2017. Establishing health benefits of bioactive food components: a basic research scientist's perspective. Current Opinion in Biotechnology. 44:109-114. doi: 10.1016/j.copbio.2016.11.016.

Red cabbage microgreens lower circulating LDL, liver cholesterol and inflammatory cytokines in mice fed a high fat diet - (Peer Reviewed Journal)
Jiang, X., Huang, H., Xiao, Z., Yu, L., Pham, Q., Yokoyama, W.H., Yu, L., Luo, Y., Wang, T.T. 2016. Red cabbage microgreens lower circulating LDL, liver cholesterol and inflammatory cytokines in mice fed a high fat diet. Journal of Agricultural and Food Chemistry. 64(48):9161-9171.

Soy and gut microbiota: interaction and implication for human health - (Peer Reviewed Journal)
Huang, H., Krishnan, H.B., Pham, Q., Yu, L.L., Wang, T.T. 2016. Soy and gut microbiota: interaction and implication for human health. Journal of Agricultural and Food Chemistry. 64(46):8695-8709.

Preparation of five 3-MCPD fatty acid esters and the effects of their chemical structures on acute oral toxicity in Swiss mice - (Peer Reviewed Journal)
Liu, M., Liu, J., Wu, Y., Gao, B., Wu, P., Shi, H., Sun, X., Huang, H., Wang, T.T., Yu, L. 2016. Preparation of five 3-MCPD fatty acid esters and the effects of their chemical structures on acute oral toxicity in Swiss mice. Journal of Food Chemistry. doi: 10.1002/jsfa.7805.

Components characterization of total tetraploid jiaogulan (Gynostemma pentaphylla) saponin and its cholesterol-lowering properties - (Peer Reviewed Journal)
Liu, J., Li, Y., Haiming, S., Wang, T.T., Wu, X., Sun, X., Yu, L. 2016. Components characterization of total tetraploid jiaogulan (Gynostemma pentaphylla) saponin and its cholesterol-lowering properties. Journal of Functional Foods. 23: 542-555.

3-MCPD 1-palmitate induced renal tubular cell apoptosis in vivo via JNK/p53 pathway - (Peer Reviewed Journal)
Liu, M., Huang, G., Wang, T.T., Sun, X., Yu, L. 2016. 3-MCPD 1-palmitate induced renal tubular cell apoptosis in vivo via JNK/p53 pathway. Toxicological Sciences. 151(1):181-92. doi: 10.1093/toxsci/lfw033.

Identification of liver CYP51 as a gene responsive to circulating cholesterol in a hamster model - (Peer Reviewed Journal)
Huang, H., Xie, Z., Yokoyama, W.H., Yu, L., Wang, T.T. 2016. Identification of liver CYP51 as a gene responsive to circulating cholesterol in a hamster model. Journal of Nutritional Science. doi: 10.1017/jns.2016.3eCollection2016.

Safety of Bifidobacterium animalis subsp. lactis (B. lactis) strain BB-12-supplemented yogurt in healthy adults on antibiotics: a phase I safety study - (Peer Reviewed Journal)
Merenstein, D.J., Tan, T.P., Molokin, A., Smith, K.H., Roberts, R.F., Shara, N.M., Mete, M., Sanders, M.E., Solano Aguilar, G. 2015. Safety of Bifidobacterium animalis subsp. lactis (B. lactis) strain BB-12-supplemented yogurt in healthy adults on antibiotics: A phase I safety study. Gut Microbes. 6(1):66-77. DOI: 10.1080/19490976.2015.