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United States Department of Agriculture

Agricultural Research Service

Related Topics

Daniel Null
Animal Genomics and Improvement Laboratory
Biological Science Lab Technician (Animals)

Phone: (301) 504-5068
Fax: (301) 504-8092
Room 324

10300 BALTIMORE AVENUE
BLDG 005 BARC-WEST
BELTSVILLE , MD 207052350


Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Phenotypic and genetic effects of recessive haplotypes on yield, longevity, and fertility -
Cole, J.B., Null, D.J., Van Raden, P.M. 2016. Phenotypic and genetic effects of recessive haplotypes on yield, longevity, and fertility. Journal of Dairy Science. 99(9):7274-7288.
Identification of a nonsense mutation in APAF1 that is likely causal for a decrease in reproductive efficiency in Holstein dairy cattle -
Adams, H.A., Sonstegard, T.S., Van Raden, P.M., Null, D.J., Van Tassell, C.P., Larkin, D.M., Lewin, H.A. 2016. Identification of a nonsense mutation in APAF1 that is likely causal for a decrease in reproductive efficiency in Holstein dairy cattle. Journal of Dairy Science. 99(8):6693-6701.
Use of a threshold animal model to estimate calving ease and stillbirth (co)variance components for US Holsteins -
Cole, J.B., Null, D.J., Tsuruta, S. 2016. Use of a threshold animal model to estimate calving ease and stillbirth (co)variance components for US Holsteins. Journal of Dairy Science. 99(E-Suppl. 1)/Journal of Animal Science. 94(E-Suppl. 5):182-183(abstr. 0385).
Genomic analysis of lactation persistency in four breeds of dairy cattle -
Cole, J.B., Null, D.J., Parker Gaddis, K.L. 2016. Genomic analysis of lactation persistency in four breeds of dairy cattle. Journal of Dairy Science. 99(E-Suppl. 1)/Journal of Animal Science. 94(E-Suppl. 5):156(abstr. 0333).
Exploring the feasibility of using copy number variants as genetic markers through large-scale whole genome sequencing experiments -
Bickhart, D.M., Xu, L., Hutchison, J.L., Cole, J.B., Null, D.J., Schroeder, S.G., Song, J., Garcia, J.F., Sonstegardq, T.S., Van Tassell, C.P., Schnabel, R.D., Taylor, J.F., Lewin, H.A., Liu, G. 2016. Exploring the feasibility of using copy number variants as genetic markers through large-scale whole genome sequencing experiments. Journal of Dairy Science. 99(E-Suppl. 1)/Journal of Animal Science. 94(E-Suppl. 5):142(abstr. 0306).
Explorations in genome-wide association studies and network analyses with dairy cattle fertility traits -
Parker Gaddis, K.L., Null, D.J., Cole, J.B. 2016. Explorations in genome-wide association studies and network analyses with dairy cattle fertility traits. Journal of Dairy Science. 99(8):6420-6435.
Diversity and population-genetic properties of copy number variations and multicopy genes in cattle -
Bickhart, D.M., Xu, L., Hutchison, J.L., Cole, J.B., Null, D.J., Schroeder, S.G., Song, J., Garcia, J., Van Tassell, C.P., Sonstegard, T.S., Schnabel, R.D., Taylor, J.F., Lewin, H.A., Liu, G. 2016. Diversity and population-genetic properties of copy number variations and multicopy genes in cattle [abstract]. USDA NIFA Animal Genome Program PD Meeting, January 8, 2016, San Diego, California.
Use of single nucleotide polymorphisms in candidate genes associated with daughter pregnancy rate for prediction of genetic merit for reproduction in Holstein cows -
Ortega, M., Denicol, A.C., Cole, J.B., Null, D.J., Hansen, P.J. 2016. Use of single nucleotide polymorphisms in candidate genes associated with daughter pregnancy rate for prediction of genetic merit for reproduction in Holstein cows. Animal Genetics. 47(3):288–297.
Reducing animal sequencing redundancy by preferentially selecting animals with low-frequency haplotypes -
Bickhart, D.M., Hutchison, J.L., Null, D.J., Van Raden, P.M., Cole, J.B. 2016. Reducing animal sequencing redundancy by preferentially selecting animals with low-frequency haplotypes. Journal of Dairy Science. 99(7):5526-5534.
Cattle sex-specific recombination and genetic control from a very large pedigree -
Ma, L., O'Connell, J.R., Van Raden, P.M., Shen, B., Padhi, A., Sun, C., Bickhart, D.M., Cole, J.B., Null, D.J., Liu, G., Da, Y., Wiggans, G.R. 2015. Cattle sex-specific recombination and genetic control from a very large pedigree. PLoS Genetics. 11(11):e1005387.
Single nucleotide polymorphisms associated with thermoregulation in lactating dairy cows exposed to heat stress -
Dikmen, S., Wang, X., Ortega, M., Null, D.J., Cole, J.B., Hansen, P.J. 2015. Single nucleotide polymorphisms associated with thermoregulation in lactating dairy cows exposed to heat stress. Journal of Animal Breeding and Genetics. 132(6):409-419.
Assignment of polled status using single nucleotide polymorphism genotypes and predicted gene content -
Null, D.J., Cole, J.B., Sun, C., Van Raden, P.M. 2015. Assignment of polled status using single nucleotide polymorphism genotypes and predicted gene content. Journal of Dairy Science. 98(Suppl. 2)/Journal of Animal Science 93(Suppl. 3):800(abstr. 647).
Single nucleotide polymorphisms in specific candidate genes are associated with phenotypic differences in days open for first lactation in Holstein cows -
Ortega, M., Denicol, A., Null, D.J., Cole, J.B., Hansen, P.J. 2015. Single nucleotide polymorphisms in specific candidate genes are associated with phenotypic differences in days open for first lactation in Holstein cows. Journal of Dairy Science. 98(Suppl. 2)/Journal of Animal Science 93(Suppl. 3):648–649(abstr. W85).
Genetic base changes for December 2014 -
Van Raden, P.M., Tooker, M.E., Wright, J.R., Cole, J.B., Null, D.J., Lawlor, T.J. 2014. Genetic base changes for December 2014. AIP Research Report BASE3(10-14).
Dissection of genomic correlation matrices of US Holsteins using multivariate factor analysis Reprint Icon -
Macciotta, N., Dimauro, C., Null, D.J., Gaspa, G., Castellini, M., Cole, J.B. 2015. Dissection of genomic correlation matrices of US Holsteins using multivariate factor analysis. Journal of Animal Breeding and Genetics. 132(1):9-20.
The identification of a putative mutation for SLICK hair coat in Senepol cattle -
Increasing the number of single nucleotide polymorphisms used in genomic evaluations of dairy cattle -
Wiggans, G.R., Cooper, T.A., Null, D.J., Van Raden, P.M. 2014. Increasing the number of single nucleotide polymorphisms used in genomic evaluations of dairy cattle. World Congress of Genetics Applied in Livestock Production. Vancouver, Canada, Aug. 17–22. 3 pp.
Using haplotypes to unravel the inheritance of Holstein coat color for a larger audience -
Lawlor, T.J., Van Raden, P.M., Null, D.J., Levisee, J., Dorhorst, B. 2014. Using haplotypes to unravel the inheritance of Holstein coat color for a larger audience. World Congress of Genetics Applied in Livestock Production. Vancouver, Canada, Aug. 17–22. 3 pp.
Single nucleotide polymorphisms in candidate genes related to daughter pregnancy rate in Holstein cows -
Ortega, M.S., Denicol, A.C., Null, D.J., Cole, J.B., Hansen, P.J. 2014. Single nucleotide polymorphisms in candidate genes related to daughter pregnancy rate in Holstein cows. World Congress of Genetics Applied in Livestock Production. Vancouver, Canada, Aug. 17–22. 2 pp.
The hunt for a functional mutation affecting conformation and calving traits on chromosome 18 in Holstein cattle -
Cole, J.B., Hutchison, J.L., Null, D.J., Van Raden, P.M., Liu, G., Schroeder, S.G., Smith, T.P., Sonstegard, T.S., Van Tassell, C.P., Bickhart, D.M. 2014. The hunt for a functional mutation affecting conformation and calving traits on chromosome 18 in Holstein cattle. World Congress of Genetics Applied in Livestock Production. Vancouver, Canada, Aug. 17–22. 3 pp.
Genotypes are useful for more than genomic evaluation -
Van Raden, P.M., Sun, C., Cooper, T.A., Null, D.J., Cole, J.B. 2014. Genotypes are useful for more than genomic evaluation. International Committee on Animal Recording(ICAR). Proc. 39th Int. Comm. Anim. Recording Sess., Berlin, Germany, May 19–23, 4 pp.
Calculation and delivery of US genomic evaluations for dairy cattle -
Wiggans, G.R., Cooper, T.A., Van Raden, P.M., Null, D.J., Hutchison, J.L., Meland, O.M., Tooker, M.E., Norman, H.D. 2014. Calculation and delivery of US genomic evaluations for dairy cattle. Journal of Dairy Science. 97(E-Suppl. 1):77–78 (abstr. 0152).
Bovine exome sequence analysis and targeted SNP genotyping of recessive fertility defects HH2, HH3, and BH1 reveals causative mutation in SMC2 for HH3 Reprint Icon -
Mc Clure, M., Bickhart, D.M., Null, D.J., Van Raden, P.M., Xu, L., Wiggans, G.R., Liu, G., Schroeder, S.G., Glasscock, J., Armstrong, J., Cole, J.B., Sonstegard, T.S., Van Tassell, C.P. 2014. Bovine exome sequence analysis and targeted SNP genotyping of recessive fertility defects HH2, HH3, and BH1 reveals causative mutation in SMC2 for HH3. PLoS One. 9(3):e92769.
Genomic evaluation, breed identification, and discovery of a haplotype affecting fertility for Ayrshire dairy cattle Reprint Icon -
Cooper, T.A., Wiggans, G.R., Null, D.J., Hutchison, J.L., Cole, J.B. 2014. Genomic evaluation, breed identification, and discovery of a haplotype affecting fertility for Ayrshire dairy cattle. Journal of Dairy Science. 97(6):3878-3882.
Candidate causative mutation on BTA18 associated with calving and conformation traits in Holstein bulls -
Cole, J.B., Hutchison, J.L., Null, D.J., Van Raden, P.M., Liu, G., Schroeder, S.G., Sonstegard, T.S., Van Tassell, C.P., Bickhart, D.M. 2014. Candidate causative mutation on BTA18 associated with calving and conformation traits in Holstein bulls. Plant and Animal Genome Conference Proceedings. Plant Animal Genome XXII, San Diego, CA, Jan. 11–15, P1097.
Single nucleotide polymorphisms in candidate genes associated with fertilizing ability of sperm and subsequent embryonic development in cattle Reprint Icon -
Cochran, S.D., Cole, J.B., Null, D.J., Hansen, P.J. 2013. Single nucleotide polymorphisms in candidate genes associated with fertilizing ability of sperm and subsequent embryonic development in cattle. Biology of Reproduction. 89(3):69.
Genome-wide association mapping for identification of quantitative trait loci for rectal temperature during heat stress in Holstein cattle Reprint Icon -
Dikmen, S., Cole, J.B., Null, D.J., Hansen, P.J. 2013. Genome-wide association mapping for identification of quantitative trait loci for rectal temperature during heat stress in Holstein cattle. PLoS One. 8(7):e69202.
Discovery of single nucleotide polymorphisms in candidate genes associated with fertility and production traits in Holstein cattle Reprint Icon -
Cochran, S.D., Cole, J.B., Null, D.J., Hansen, P.J. 2013. Discovery of single nucleotide polymorphisms in candidate genes associated with fertility and production traits in Holstein cattle. BioMed Central (BMC) Genetics. 14:49.
Genomic evaluation and identification of haplotype affecting fertility for Ayrshire dairy cattle -
Cooper, T.A., Wiggans, G.R., Null, D.J., Hutchison, J.L. 2013. Genomic evaluation and identification of haplotype affecting fertility for Ayrshire dairy cattle. Journal of Dairy Science. 96(E-Suppl. 1):74 (abstr. T206).
Optimal age at first calving for U.S. dairy cattle -
Cole, J.B., Hutchison, J.L., Bickhart, D.M., Null, D.J. 2013. Optimal age at first calving for U.S. dairy cattle. Journal of Dairy Science. 96(E-Suppl. 1):289–290 (abstr. W188).
Dissection of genomic correlation matrices using multivariate factor analysis in dairy and dual-purpose cattle breeds -
Macciotta, N.P., Dimauro, C., Vicario, D., Cole, J.B., Null, D.J. 2013. Dissection of genomic correlation matrices using multivariate factor analysis in dairy and dual-purpose cattle breeds. Journal of Dairy Science. 96(E-Suppl. 1):618 (abstr. 541).
Fine mapping for Weaver Syndrome in the Brown Swiss breed with the identification of possible casual mutations across NRCAM, PNPLA8, and CTTNBP2 and Developement of a diagnostic SNP haplotype Reprint Icon -
Mcclure, M.C., Kim, E., Bickhart, D.M., Null, D.J., Cooper, T.A., Cole, J.B., Wiggans, G.R., Marsan, P.A., Colli, L., Santus, E., Liu, G., Schroeder, S.G., Matukumalli, L., Van Tassell, C.P., Sonstegard, T.S. 2013. Fine mapping for Weaver Syndrome in the Brown Swiss breed with the identification of possible casual mutations across NRCAM, PNPLA8, and CTTNBP2 and Developement of a diagnostic SNP haplotype. PLoS One. 8(3):e59251.
Visualization of the transmission of direct genomic values for paternal and maternal chromosomes for 15 traits in U.S. Brown Swiss, Holstein, and Jersey cattle Reprint Icon -
Cole, J.B., Null, D.J. 2013. Visualization of the transmission of direct genomic values for paternal and maternal chromosomes for 15 traits in US Brown Swiss, Holstein, and Jersey cattle. Journal of Dairy Science. 96(4):2713-2726.
Identification of a nonsense mutation in CWC15 associated with decreased reproductive efficiency in Jersey cattle Reprint Icon -
Sonstegard, T.S., Cole, J.B., Van Raden, P.M., Van Tassell, C.P., Null, D.J., Schroeder, S.G., Bickhart, D.M., Mcclure, M.C. 2013. Identification of a nonsense mutation in CWC15 associated with decreased reproductive efficiency in Jersey cattle. PLoS One. 8(1):e54872.
Genomic imputation and evaluation using high density Holstein genotypes -
Van Raden, P.M., Null, D.J., Sargolzaei, M., Wiggans, G.R., Tooker, M.E., Cole, J.B., Sonstegard, T.S., Connor, E.E., Winters, M., Van Kaam, J., Van Doormaal, B.J., Faust, M.A., Doak, G.A. 2013. Genomic imputation and evaluation using high density Holstein genotypes. Journal of Dairy Science. 96(1):668-678.
Fine mapping and discovery of recessive mutations that cause abortions in dairy cattle -
Van Raden, P.M., Null, D.J., Sonstegard, T.S., Adams, H.A., Van Tassell, C.P., Olson, K.M. 2012. Fine mapping and discovery of recessive mutations that cause abortions in dairy cattle. Journal of Dairy Science. 95(Suppl. 2):ii–iii(abstr. LB6). 2012.
Reliability increases from combining 50,000- and 777,000-marker genotypes from four countries -
Van Raden, P.M., Olson, K.M., Null, D.J., Sargolzaei, M., Winters, M., Van Kaam, J. 2012. Reliability increases from combining 50,000- and 777,000-marker genotypes from four countries. Interbull Annual Meeting Proceedings. Cork, Ireland, May 28–June 1, 4 pp.
Short communication: Projecting milk yield using best prediction and the MilkBot lactation model -
Cole, J.B., Ehrlich, J.L., Null, D.J. 2012. Short communication: Projecting milk yield using best prediction and the MilkBot lactation model. Journal of Dairy Science. 95(7):4041-4044.
Genomic evaluation of rectal temperature in Holstein cattle -
Dikmen, S., Cole, J.B., Null, D.J., Hansen, P.J. 2012. Genomic evaluation of rectal temperature in Holstein cattle. Journal of Dairy Science. 95(Suppl. 2):401(abstr. 327). 2012.
Heritability of rectal temperature and genetic correlations with production and reproduction traits in dairy cattle -
Dikmen, S., Cole, J.B., Null, D.J., Hansen, P.J. 2012. Heritability of rectal temperature and genetic correlations with production and reproduction traits in dairy cattle. Journal of Dairy Science. 95(6):3401-3405.
Harmful recessive effects on fertility detected by absence of homozygous haplotypes -
Van Raden, P.M., Olson, K.M., Null, D.J., Hutchison, J.L. 2011. Harmful recessive effects on fertility detected by absence of homozygous haplotypes. Journal of Dairy Science. 94(12):6153-6161.
Reporting of haplotypes with recessive effects on fertility -
Van Raden, P.M., Null, D.J., Olson, K.M., Hutchison, J.L. 2011. Reporting of haplotypes with recessive effects on fertility. Interbull Annual Meeting Proceedings. Stavanger, Norway, Aug. 26–28, 4 pp.
Genomic imputation and evaluation using 342 high density Holstein genotypes -
Van Raden, P.M., Null, D.J., Wiggans, G.R., Sonstegard, T.S., Connor, E.E. 2011. Genomic imputation and evaluation using 342 high density Holstein genotypes. Journal of Animal Science 89(E-Suppl. 1)/ Journal of Dairy Science 94(E-Suppl. 1):533(abstr. W53).
Impacts of inclusion of foreign data in genomic evaluation of dairy cattle -
Olson, K.M., Van Raden, P.M., Null, D.J. 2011. Impacts of inclusion of foreign data in genomic evaluation of dairy cattle. Journal of Animal Science 89(E-Suppl. 1)/Journal of Dairy Science 94(E-Suppl. 1):164-65(abstr. 35).
Heritability of rectal temperature and genetic correlations with production and reproduction traits in dairy cattle -
Dikmen, S., Cole, J.B., Null, D.J., Hansen, P.J. 2011. Heritability of rectal temperature and genetic correlations with production and reproduction traits in dairy cattle. Journal of Animal Science 89(E-Suppl. 1)/Journal of Dairy Science 94(E-Suppl. 1):255(abstr. 275).
Short communication: Best prediction of 305-day lactation yields with regional and seasonal effects -
Cole, J.B., Null, D.J., De Vries, A. 2011. Short communication: Best prediction of 305-day lactation yields with regional and seasonal effects. Journal of Dairy Science. 94(3):1601-1604.
Age at First Calving in Holstein Cattle in the United States -
Cole, J.B., Null, D.J. 2010. Age at First Calving in Holstein Cattle in the United States. Journal of Dairy Science. 93(E-Suppl. 1):594(abstr. W28).
Best prediction of lactation yields accounting for regional and seasonal differences -
Cole, J.B., Null, D.J. 2009. Best prediction of lactation yields accounting for regional and seasonal differences. Journal of Dairy Science. 92(E-Suppl. 1):209(abstr. T38).
Genetic Evaluation of Lactation Persistency for Five Breeds of Dairy Cattle Reprint Icon -
Cole, J.B., Null, D.J. 2009. Genetic Evaluation of Lactation Persistency for Five Breeds of Dairy Cattle. Journal of Dairy Science. 92(5):2248-2258.
Best Prediction of Yields for Long Lactations Reprint Icon -
Cole, J.B., Null, D.J., Van Raden, P.M. 2009. Best Prediction of Yields for Long Lactations. Journal of Dairy Science. 92(4):1796-1810.
A data exchange format and national database for producer-recorded health event data from on-farm management software -
Cole, J.B., Null, D.J., Bacheller, L.R. 2008. A data exchange format and national database for producer-recorded health event data from on-farm management software. Journal of Dairy Science. 91(E-Suppl. 1):2–3(abstr. T6).
Last Modified: 5/2/2016
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