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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Genomics and Improvement Laboratory » Research » Publications at this Location » Publication #303404

Research Project: Improving Genetic Predictions in Dairy Animals Using Phenotypic and Genomic Information

Location: Animal Genomics and Improvement Laboratory

Title: Single nucleotide polymorphisms in candidate genes related to daughter pregnancy rate in Holstein cows

Author
item Ortega, Martha - University Of Florida
item Denicol, Anna - University Of Florida
item Null, Daniel
item Cole, John
item Hansen, Peter - University Of Florida

Submitted to: World Congress of Genetics Applied in Livestock Production
Publication Type: Proceedings
Publication Acceptance Date: 4/21/2014
Publication Date: 8/17/2014
Citation: Ortega, M.S., Denicol, A.C., Null, D.J., Cole, J.B., Hansen, P.J. 2014. Single nucleotide polymorphisms in candidate genes related to daughter pregnancy rate in Holstein cows. World Congress of Genetics Applied in Livestock Production. Vancouver, Canada, Aug. 17–22. 2 pp.

Interpretive Summary:

Technical Abstract: ABSTRACT: Previously, a candidate gene approach identified 40 SNPs associated with daughter pregnancy rate (DPR) in dairy bulls. We evaluated 39 of these SNPs for relationship to DPR in a separate population of Holstein cows grouped on their predicted transmitting ability for DPR: <= -1 (n=1266) and >= 1.5 (n=1071). Genotyping was by Sequenom MassARRAY®. Of the 39 SNPs, 30 were related to DPR in the same direction as previously reported, with significance for 18. SNPs that explained the greatest proportion of variation in DPR were COQ9 (3.0%), HSD17B12 (1.6%), APBB1 (1.3%), FUT1 (1.2%), and C7H19orf60 (1.2%). Overall, the 39 SNPs explained 17.6% of the variation in DPR. Results indicate that a large proportion of candidate gene SNPs previously related to DPR are predictive in a separate population. Use of these SNPs may increase reliability of genomic estimates of DPR.