|Smith, Timothy - Tim|
|Kappes, Steven - Steve|
Submitted to: Meeting Abstract
Publication Type: Proceedings
Publication Acceptance Date: 10/27/1997
Publication Date: N/A
Citation: Interpretive Summary:
Technical Abstract: A partially recessive locus (mh) causes a heritable syndrome of generalized muscular hypertrophy in cattle, a result of cellular hyperplasia. The mh locus is mapped to an interval on bovine chromosome 2 (BTA2) between the COL3A1 and PROC genes in both Belgian Blue and Piedmontese breeds, suggesting the same locus is responsible in this breed. We show that myostatin, a member of the TGF-beta gene family, maps to the same interval, making it a positional candidate gene for mh. RT-PCR analysis shows that myostatin is present at approximately normal levels at the RNA level in Belgian Blue embryos. However, mutation analysis shows that each breed has a distinct mutation in the coding portion of the cDNA that is predicted to interfere with the function of the gene.