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Title: RESPONSE OF SKELETAL MUSCLE PROTEIN SYNTHESIS (PSM) TO INSULIN (INS) DECLINES WITH DEVELOPMENT

Author
item Wray Cahen, Diane
item NGUYEN, H
item BURRIN, D
item BECKETT, P
item FIOROTTO, M
item WESTER, T
item YU, H
item REEDS, Q
item DAVIS, T

Submitted to: Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 4/1/1997
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Response Of Skeletal Muscle Protein Synthesis (Psm) To Insulin (Ins) Declin With Development. D. Wray-Cahen, H.V. Nguyen, D.G. Burrin, P.R. Beckett, M. Fiorotto, T.J. Wester, H. Yu, P.J. Reeds, T.A. Davis. USDA/ARS CNRC, Baylor College of Medicine. Houston, TX 77030. The stimulation of PSm by feeding declines with development. To determine if this decrease reflects age differences in the response to INS, we determined the in vivo response of to INS in the longissimus dorsi by infusing 0, 30, or 100 ng INS/(kg0.66$mi during euglycemic-amino acid clamps in 12h fasted 7- (d7; n=7) and 26- (d26 n=9) day-old suckling pigs. PSm was greater in d7 than d26 pigs (p<0.001). When INS was infused to obtain fed, steady-state plasma INS concentrations (30 INS dose), the PSm response to INS was greater at d7 (+54%) than at d26 (+39%). When INS was infused to obtain INS concentrations normally observed after refeeding (100 INS dose), PSm stimulation was maintained at d7 (+61%), and lower at d26 (+21%). We conclude that (a) physiological levels of INS stimulated PSm in suckling pigs and (b) this response to INS declines with development. 11.1"1.4