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United States Department of Agriculture

Agricultural Research Service


item Harvey, Roger
item Kubena, Leon
item Rottinghaus, George
item Turk, James
item Buckley, Sandra - Sandy

Submitted to: American Association of Veterinary Laboratory Diagnosticians
Publication Type: Abstract Only
Publication Acceptance Date: 7/1/1997
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: In two studies, the effects of moniliformin (M)-contaminated diets from Fusarium fujikuroi culture material on growing barrows were evaluated. In the first study, six barrows (3 replicates of 2 each, mean body weight, 17.8 kg) per group (4 groups; 24 barrows total) were fed diets calculated to contain: 0 mg M/kg feed (control); 25 mg M/kg feed; 50 mg M/kg feed; or 100 mg M/kg feed for 28 days. In the second study, the same experimental design and numbers of barrows (mean body weight, 15.3 kg) were used and diets were formulated to contain: 0 mg M/kg feed (control); 50 mg M/kg feed; 100 mg M/kg feed; or 200 mg M/kg feed. Diets of 100 mg or 200 mg M/kg feed reduced body weight and body weight gain and feed consumption. Serum biochemical analytes were affected by 100 to 200 mg M/kg feed. Hematologic values were affected by 50, 100, and 200 mg M/kg feed. In the first study, 1 barrow in the 100 mg M-treated group died, and in the second study, mortality was 1/6 in the 100 mg M group and 5/6 in the 200 mg M/kg feed group. Relative heart weight was increased in the 200 mg M- treated barrows, yet tissues from organs collected from treatment groups were generally histologically unimpressive. The most consistent sign of M toxicity in barrows appeared to be death induced within 2-5 days by 100 to 200 mg M/kg feed. Fortunately for swine producers, the likelihood of encountering these high concentrations of M in finished feed is small; however, additional data on the occurrence and toxicity of M will need to be collected to assess the importance of M to the livestock industry.

Last Modified: 08/19/2017
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