|Kappes, Steven - Steve|
|Smith, Timothy - Tim|
Submitted to: Genome Research
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/6/1996
Publication Date: N/A
Interpretive Summary: A bovine linkage map was developed with 1250 linked markers in 30 linkage groups that represent the 29 autosomal chromosomes and X chromosome. Fifty-four markers are associated with genes and 88 markers have been physically assigned to specific regions of chromosomes, allowing orientation of 28 linkage groups to their respective chromosomes. The four-fold increase in the number of linked markers in this map compared to previous bovine maps allows quantitative trait loci (QTL) to be mapped to a smaller region of a chromosome. This will also improve the efficiency of marker assisted selection (MAS). The current bovine map also enhances QTL mapping in sheep and goats since a large number of cattle markers have been used in developing sheep and goat linkage maps and the order of markers within linkage groups is very similar between species.
Technical Abstract: We report a bovine linkage map constructed with 1236 polymorphic DNA markers and 14 erythrocyte antigens and serum proteins that represents the largest number of linked markers within any livestock map to date. The 2990 cM map consists of two sex-specific and 29 sex-averaged, autosomal linkage groups with an average interval size of 2.5 cM. The map contains 627 new markers and 623 previously linked markers, providing a basis for integrating the four published bovine maps. Eighty-eight previously assigned markers orient all of the linkage groups relative to chromosomes except for BTA20 and 22. This map provides sufficient marker density for genomic scans of populations segregating quantitative trait loci (QTL) and subsequent implementation of marker assisted selection (MAS) mating schemes.