|Kogut, Michael - Mike|
Submitted to: Proceedings of the 45th Western Poultry Disease Conference
Publication Type: Proceedings
Publication Acceptance Date: 5/4/1996
Publication Date: N/A
Citation: Interpretive Summary:
Technical Abstract: Recent research efforts on immunological measures to control or prevent intestinal and tissue colonization of invasive Salmonella in poultry has primarily focused on the development of Salmonella vaccines. However, at least 7-10 days are required for the stimulation of the acquired immune response.Chicks are most highly susceptible to Salmonella infections during the first 4 days post-hatch, after which they become increasingly more resistant to infection. The objective of our research has been to develop a strategy for the potentiation of the avian innate immune response during the first 4-7 days of life as a means of preventing organ invasion of Salmonella in poultry. Research from our laboratory has shown that cytokines produced by T cells from chickens immunized against the paratyphoid salmonellae, S. enteritidis, confers protection to young chicks against both the paratyphoid salmonellae, S. enteritidis and S. typhimurium and the typhoid salmonellae, S. gallinarum. In addition, these cytokines from SE-immune chickens will protect turkey poults from SE organ invasion. Thus, SE-ILK can induce a cross-protection between serotypes regardless of antigenic differences which is in marked contrast to most Salmonella vaccines. These findings suggest that the mechanism of host resistance to Salmonella in poultry may be less dependent on an antigen- specific response, but more contingent on initiating the correct innate host responses early during an infection. These results show that the prophylactic treatment of chickens with SE-ILK conferred significant protection in young chicks against all serovars of Salmonella tested, this protection can be conferred by in ovo administration, and appears to protect the chicks for at least the first ten days of life.