Submitted to: American Association of Veterinary Laboratory Diagnosticians
Publication Type: Abstract only
Publication Acceptance Date: 7/10/1996
Publication Date: N/A
Citation: Interpretive Summary:
Technical Abstract: The individual and combined effects of feeding diets containing 100 mg moniliformin (M) and 16 mg deoxynivalenol (DON)/kg of diet were evaluated in male broiler chicks from 1 to 21 days of age. When compared with controls, body weight (BW), BW gain, and feed consumption were decreased by the M and M plus DON diets. Feeding M resulted in increased relative heart weight, whereas, feeding M plus DON increased relative weights of proventriculus, gizzard, and heart. There was a significant M X DON interaction (antagonistic) for heart weight in the combination treatment. Serum analytes and hematologic values affected by the M diet included increased alanine transferase activity and creatinine concentration and decreased mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration (MCHC). Feeding of M plus DON decreased glucose, hemoglobin, and MCHC. Histopathologic lesions of the M treated chicks included extensive renal tubular epithelial degeneration, plus luminal mineralization. Lesions in the M plus DON group were not as severe and were limited to generally mild tubular epithelial degeneration. Performance, serum biochemical, hematologic, or histopathologic measurements were not affected by feeding the DON diet. Results indicate additive or less than additive toxicity, but not toxic synergy, for most parameters when chicks are fed diets containing the combination of 100 mg M plus 16 mg DON/kg of feed. The likelihood of encountering these high concentrations of the mycotoxins in finished feed is small; however, additional data on the occurrence and toxicity of M will need to be collected in order to assess the importance of M to the poultry and livestock industries.