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ARS Home » Research » Publications at this Location » Publication #68676


item Deloach, John
item Nisbet, David
item Corrier, Donald

Submitted to: World Poultry Congress Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: 6/6/1996
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: We have developed a patented technology for selection of and maintenance of a defined mixture of bacteria for prevention of Salmonella in chickens. The defined competitive exclusion (CE) culture has been maintained in continuous growth for 2 1/2 years without change in contents or loss of efficacy. The mother culture known as CF3 has been used to start daughter cultures that have identical character to the mother culture. This technology of continuous growth of a mixture of bacteria mimics the ceca of a chicken. Thus, we never have to return to the chicken to obtain a starter culture. The use of a chemostat as continuous growth chamber allowed for development of defined CE cultures that will be used as the seed culture for production of commercial-scale quantities of the product. We will report data on prevention of both typhoid and paratyphoid salmonellae in poultry conducted over a 2 1/2 year period with the same CE culture. Such results have never before been presented because the seed stock for undefined cultures must be periodically isolated again from chickens and is, therefore, not an identical culture. A defined CE culture can be maintained in a chemostat outside the chicken for years, solving many of the problems associated with re-isolation from the chicken.