Submitted to: Poultry Science Association Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 3/1/1996
Publication Date: N/A
Technical Abstract: Our research on the control of organ colonization of poultry by invasive Salmonella enteritidis (SE) has focused on the development of immunoprophylactic measures. We have found an increased resistance to SE organ infectivity in chickens and turkeys conferred by the administration of SE-immune lymphokines (SE-ILK). Fowl typhoid, caused by Salmonella gallinarum (SG), is a septicemic disease of domestic birds resulting in morbidity with moderate to high mortality. The objective of the present studies was to evaluate the effect of a prophylactic treatment of broiler chicks with SE-ILK on the birds' resistance to an experimental infection with SG. On the day-of-hatch, chicks were injected i.p. with either SE- ILK, control nonimmune lymphokines (NILK), or were left untreated. Thirty min later, all chicks were orally gavaged with SG. For 10 days after challenge, morbidity and mortality were recorded. Chicks that survived were killed and their livers and spleens cultured for SG. The prophylacti treatment of chickens with SE-ILK induced significant (P = 0.005) protection against SG infection as evidenced by: 1) a reduction in mortality; 2) an increased average weight gain as compared with untreated, SG challenged controls, and 3) a reduction in the number of SG-organ- positive chicks. The results suggest that the prophylactic administration of SE-ILK can confer protection to chicks against a pathogenic salmonellae.