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Title: EVALUATION OF SALMONELLA ENTERITIDIS-IMMUNE LYMPHOKINES ON HOST RESISTANCE TO SALMONELLA GALLINARUM INFECTION IN BROILER CHICKS

Author
item Kogut, Michael - Mike
item TELLEZ, GUILLERMO - UNIV NATL AUTONAMA MX
item WONG, R - UNIV NATL AUTONAMA MX
item MCGRUDER, EDWARD - LILLY RESEARCH LABORATORY
item Hargis, Billy
item Deloach, John

Submitted to: Poultry Science Association Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 3/1/1996
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Our research on the control of organ colonization of poultry by invasive Salmonella enteritidis (SE) has focused on the development of immunoprophylactic measures. We have found an increased resistance to SE organ infectivity in chickens and turkeys conferred by the administration of SE-immune lymphokines (SE-ILK). Fowl typhoid, caused by Salmonella gallinarum (SG), is a septicemic disease of domestic birds resulting in morbidity with moderate to high mortality. The objective of the present studies was to evaluate the effect of a prophylactic treatment of broiler chicks with SE-ILK on the birds' resistance to an experimental infection with SG. On the day-of-hatch, chicks were injected i.p. with either SE- ILK, control nonimmune lymphokines (NILK), or were left untreated. Thirty min later, all chicks were orally gavaged with SG. For 10 days after challenge, morbidity and mortality were recorded. Chicks that survived were killed and their livers and spleens cultured for SG. The prophylacti treatment of chickens with SE-ILK induced significant (P