|Kappes, Steven - Steve|
Submitted to: Animal Genetics
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/15/1996
Publication Date: N/A
Interpretive Summary: Data from five laboratories were used to construct a 55 cM framework linkage map of bovine chromosome 23. Twelve of the 28 contributed loci were ordered on the framework map with a high level of statistical support. The remaining 16 loci were ordered within the framework markers. Framework maps with high statistical support for locus order will enhance ordering of additional loci as they are added to the map. The four large pedigrees used to build this framework map can be used for constructing future framework maps for the remaining bovine chromosomes.
Technical Abstract: A report of the first workshop on the genetic map of bovine chromosome 23 (BTA23) is given. Data from 28 loci were contributed by five laboratories and included a total of 11.543 informative genotypes. The combined pedigrees represented 1.930 potentially informative meioses. Eighteen of the 28 loci were common to two or more data sets and were used to construct a framework linkage map of BTA23. Twelve of the 18 common loci could be ordered on the linkage map with a likelihood ratio > 1000:1. Thus, a low resolution consensus map with a high level of support for order was constructed. The sex-averaged female and male maps span 54.5, 52.7 and 55.8 cM respectively. Sex-specific differences in recombination frequency were identified for eight pairs of framework loci. Average genetic distance between framework loci on the sex-averaged map is 5.0 cM.