Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/12/1995
Publication Date: N/A
Citation: Interpretive Summary:
Technical Abstract: Marek's disease virus (MDV) is an avian herpesvirus which causes malignant transformation of T cells in chickens. In our attempt to identify the genes of MDV which encode proteins or antigens important for virus neutralization and virulence, we constructed a genomic expression library. A monoclonal antibody specific for MDV common antigen was used to screen this library and a recombinant MDV phage clone was identified. Sequence analysis revealed an open reading frame encoding a protein homologous to the HSV large subunit of the ribonucleotide reductase (RR1). This paper describes the characterization of the small subunit of the MDV RR2.