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Title: IDENTIFICATION OF A SMALL SUBUNIT OF RIBONUCLEOTIDE REDUCTASE GENE OF MAREK'S DISEASE VIRUS

Author
item Lee, Lucy
item WU, PING - MICHIGAN STATE UNIVERSITY

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/12/1995
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Marek's disease virus (MDV) is an avian herpesvirus which causes malignant transformation of T cells in chickens. In our attempt to identify the genes of MDV which encode proteins or antigens important for virus neutralization and virulence, we constructed a genomic expression library. A monoclonal antibody specific for MDV common antigen was used to screen this library and a recombinant MDV phage clone was identified. Sequence analysis revealed an open reading frame encoding a protein homologous to the HSV large subunit of the ribonucleotide reductase (RR1). This paper describes the characterization of the small subunit of the MDV RR2.