|PONCE DE LEON, F|
Submitted to: Mammalian Genome
Publication Type: Abstract Only
Publication Acceptance Date: 5/30/1995
Publication Date: N/A
Technical Abstract: Interleukin 2 receptor (IL-2R) is composed of three polypeptide chains, alpha, beta, and gamma, and plays a key role in the proliferation of activated T lymphocytes. A partial bovine genomic IL-2R-alpha sequence that contains approximately 8 kb of 5'-flanking region, exon 1, and 2 kb of intron 1, was cloned and assigned to chromosome 13q13-q14 by fluorescence in situ hybridization (FISH). The promoter region of bovine IL-2R-alpha shows significant sequence similarity to its human and mouse counterparts, suggesting that regulation of IL-2R-alpha gene expression is conserved among these species. Physical assignment of IL-2R-alpha to bovine chromosome 13 also demonstrates syntenic conservation of this gene between human, mouse and cattle.