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United States Department of Agriculture

Agricultural Research Service


Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Biomarkers of sarcopenia in clincal trials recommendations from the international working group on sarcopenia

item Cesari, Matteo
item Fielding, Roger
item Pahor, Marco
item Goodpaster, Bret
item Hellerstein, Marc
item Abellan Van Kan, Gabor
item Anker, Stefan
item Rutkove, Seward
item Vrijbloed, Jan Willem
item Isaac, Maria
item Rolland, Yves
item M'rini, Christine
item Aubertin-leheudre, Mylene
item Cedarbaum, Jesse
item Zamboni, Giuseppe
item Sieber, Cornel
item Laurent, Didier
item Evans, William
item Roubenoff, Ronenn
item Morley, John
item Vellas, Bruno

Submitted to: Journal of Cachexia, Sarcopenia and Muscle
Publication Type: Review Article
Publication Acceptance Date: 6/11/2012
Publication Date: 8/30/2012
Citation: Cesari, M., Fielding, R., Pahor, M., Goodpaster, B., Hellerstein, M., Abellan Van Kan, G., Anker, S.D., Rutkove, S., Vrijbloed, J., Isaac, M., Rolland, Y., M'Rini, C., Aubertin-Leheudre, M., Cedarbaum, J.M., Zamboni, G., Sieber, C., Laurent, D., Evans, W.J., Roubenoff, R., Morley, J.E., Vellas, B. 2012. Biomarkers of sarcopenia in clincal trials recommendations from the international working group on sarcopenia. Journal of Cachexia, Sarcopenia and Muscle. 3(3):181-190.

Interpretive Summary:

Technical Abstract: Sarcopenia, the age-related skeletal muscle decline, is associated with relevant clinical and socioeconomic negative outcomes in older persons. The study of this phenomenon and the development of preventive/therapeutic strategies represent public health priorities. The present document reports the results of a recent meeting of the International Working Group on Sarcopenia (a task force consisting of geriatricians and scientists from academia and industry) held on June 7-8, 2011 in Toulouse (France). The meeting was specifically focused at gaining knowledge on the currently available biomarkers (functional, biological, or imaging-related) that could be utilized in clinical trials of sarcopenia and considered the most reliable and promising to evaluate age-related modifications of skeletal muscle. Specific recommendations about the assessment of aging skeletal muscle in older people and the optimal methodological design of studies on sarcopenia were also discussed and finalized. Although the study of skeletal muscle decline is still in a very preliminary phase, the potential great benefits derived from a better understanding and treatment of this condition should encourage research on sarcopenia. However, the reasonable uncertainties (derived from exploring a novel field and the exponential acceleration of scientific progress) require the adoption of a cautious and comprehensive approach to the subject.

Last Modified: 06/26/2017
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