Submitted to: Domestic Animal Endocrinology
Publication Type: Review Article
Publication Acceptance Date: 12/19/2008
Publication Date: 4/1/2009
Citation: Rhoads, R., Fernyhough, M.E., Liu, X., Mcfarland, D., Velleman, S., Hausman, G.J., Dodson, M.V. 2009. Invited Review: Extrinsic regulation of domestic animal-derived myogenic satellite cells II. Domestic Animal Endocrinology. v:36, issue 3, p. 111-126. Interpretive Summary: Satellite cells represent sources of new muscle cells recruited into muscle during growth and other processes. Key biological aspects of the regulation of satellite cells are detailed and illustrated. The availability of this information will allow critical examination and appraisal of the factors influencing the process of satellite cells converting to myogenic cells. Understanding regulation of these processes will ultimately lead to means to control skeletal muscle deposition in the meat animal.
Technical Abstract: The existence of myogenic satellite cells was reported some forty-seven years ago, and, since that time, satellite cell research has flourished. So much new information is generated (daily) on these cells that it can be difficult for individuals to keep abreast of important issues related to the activation, proliferation, modulation of the activity of other cell types, differentiation of the cells to facilitate normal skeletal muscle growth and development, or to repair damaged myofibers. The intent of this review is to summarize new information about the extrinsic regulation of myogenic satellite cells, and to provide specific mechanisms involved in altering satellite cell physiology. Where possible, examples from agriculturally important animals are used for illustrative purposes.