Submitted to: Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 12/1/2007
Publication Date: 4/5/2008
Publication URL: http://www.fasebj.org/cgi/content/meeting_abstract/22/1_MeetingAbstracts/445.2
Citation: Josse, A.R., Kendall, C.W., Marchie, A., Nguyen, T.H., Blumberg, J., Lapsley, K.G., Jenkins, D.J. 2008. Almonds and Biomarkers of Lipid Peroxidation: A Randomized Controlled Cross-over Trial. FASEB Journal. 22:44.2. Interpretive Summary:
Technical Abstract: Background: Nut consumption is associated with a reduced risk of coronary heart disease (CHD). Almonds, in addition to their cholesterol-lowering properties, have been shown to reduce oxidized LDL concentrations. However, their effect on other markers of lipid peroxidation is unknown. Methods: Twenty seven men and women with hyperlipidemia consumed 3 iso-energetic (mean 423 kcal/d) supplements as part of their therapeutic diets for 1 month each. Supplements consisted of full-dose almonds (73+/-3g/d), half-dose almonds plus half-dose muffins and full-dose muffins. Subjects were assessed at wks 0, 2 and 4.Results: At 4 wks, the full-dose almonds significantly reduced serum concentrations of malondialdehyde (MDA) (P=0.040) and creatinine-adjusted urinary isoprostane output (P=0.026) compared to the full-dose muffins. No effect was seen in serum levels of alpha- or gamma- tocopherol, adjusted or unadjusted for total cholesterol. Conclusion: Almond consumption significantly decreased oxidative damage to 2 additional biomarkers of lipid peroxidation, serum MDA and urinary isoprostanes, further supporting our previous finding that almonds reduced the oxidation of LDL. This provides a further mechanism, in addition to cholesterol-lowering, that may account for the reduction in CHD risk associated with nut consumption.