Author
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Tabatabai, Louisa |
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Submitted to: Avian Diseases
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 9/11/2007 Publication Date: 4/1/2008 Citation: Tabatabai, L.B. 2008. Identification of Pasteurella multocida CHAPS-soluble outer membrane proteins. Avian Diseases. 52:147-149. Interpretive Summary: Fowl cholera continues to be of concern to the poultry industry, especially for turkey growers. This disease costs the turkey industry millions of dollars annually. In order to gain a better understanding of Pasteurella multocida virulence factors involved in colonization and pathogenesis, the outer membrane proteins of P. multocida were examined using specialized protein analysis techniques. Among the four proteins identified, two were involved in carbohydrate uptake and synthesis and two of the proteins were identified as potential virulence factors. Information about these proteins will help us to design better vaccines for fowl cholera. Technical Abstract: Fowl cholera continues to be of concern to the poultry industry, especially for turkey growers. This disease costs the turkey industry millions of dollars annually. In order to gain a better understanding of Pasteurella multocida virulence factors involved in colonization and pathogenesis, the outer membrane proteins of P. multocida were examined using proteomics. Four additional proteins of the outer membrane proteome were identified, completing the protein complement of the detergent-soluble membrane cross-protective protein fraction. These are Protective Bacterial Surface Antigen, OMA87 (Accession no. 15603857); heme-hemopexin receptor, HemR (Accession no. 15602441); lactate permease, LctP (Accession no. 15603717); and heptosyl transferase F, RfaF (Accession no. 15603709). Both the Oma87 and the HemR proteins would be of interest for further study because of their purported roles in pathogenesis of P. multocida. |
